{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:26:26Z","timestamp":1782573986309,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005118","name":"Japan Atomic Energy Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005118","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000\u00a0Bq\/m3 and were administered 50% ethanol (alcohol) and 300\u00a0mg\/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500\u00a0Bq\/m3) and AA administration 24\u00a0h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500\u00a0Bq\/m3) and AA administration 24\u00a0h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000\u00a0Bq\/m3 thoron inhalation was lower than that after 500\u00a0Bq\/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500\u00a0Bq\/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500\u00a0Bq\/m3 was more effective than that at 2000\u00a0Bq\/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500\u00a0Bq\/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.<\/jats:p>","DOI":"10.1093\/jrr\/rrac046","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T04:57:41Z","timestamp":1657601861000},"source":"Crossref","is-referenced-by-count":3,"title":["Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice"],"prefix":"10.1093","author":[{"given":"Takahiro","family":"Kataoka","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences , Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences , Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Naoe","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences , Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Ningyo-toge Environmental Engineering Center , Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sakoda","sequence":"additional","affiliation":[{"name":"Ningyo-toge Environmental Engineering Center , Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Ningyo-toge Environmental Engineering Center , Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Mitsunobu","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Dentistry and Pharmaceutical Sciences , Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonori","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences , Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , 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