{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:50:10Z","timestamp":1788119410669,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"publisher","award":["2018\/10221"],"award-info":[{"award-number":["2018\/10221"]}],"id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["2019050"],"award-info":[{"award-number":["2019050"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Radiotherapy (RT) of head and neck (H&amp;N) cancer is known to cause both early- and late-occurring toxicities. To better appraise normal tissue responses and their dependence on treatment parameters such as radiation field and type, as well as dose and fractionation scheme, a preclinical model with relevant endpoints is required. 12-week old female C57BL\/6\u00a0J mice were irradiated with 100 or 180\u00a0kV X-rays to total doses ranging from 30 to 85\u00a0Gy, given in 10 fractions over 5\u00a0days. The radiation field covered the oral cavity, swallowing structures and salivary glands. Monte Carlo simulations were employed to estimate tissue dose distribution. The follow-up period was 35\u00a0days, in order to study the early radiation-induced effects. Baseline and post irradiation investigations included macroscopic and microscopic examinations of the skin, lips, salivary glands and oral mucosa. Saliva sampling was performed to assess the salivary gland function following radiation exposure. A dose dependent radiation dermatitis in the skin was observed for doses above 30\u00a0Gy. Oral mucositis in the tongue appeared as ulcerations on the ventral surface of the tongue for doses of 75\u201385\u00a0Gy. The irradiated mice showed significantly reduced saliva production compared to controls. In summary, a preclinical model to investigate a broad panel of normal tissue responses following fractionated irradiation of the H&amp;N region was established. The optimal dose to study early radiation-induced effects was found to be around 75\u00a0Gy, as this was the highest tolerated dose that gave acute effects similar to that observed in cancer patients.<\/jats:p>","DOI":"10.1093\/jrr\/rrac066","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T17:05:37Z","timestamp":1663347937000},"page":"44-52","source":"Crossref","is-referenced-by-count":23,"title":["A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck"],"prefix":"10.1093","volume":"64","author":[{"given":"Inga Solg\u00e5rd","family":"Juvkam","sequence":"first","affiliation":[{"name":"Institute of Oral Biology, Faculty of Dentistry, University of Oslo , 0372 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Zlygosteva","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, University of Oslo , 0371 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delmon","family":"Arous","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, University of Oslo , 0371 Oslo , Norway"},{"name":"Department of Medical Physics, Cancer Clinic, Oslo University Hospital , 0379 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde Kanli","family":"Galtung","sequence":"additional","affiliation":[{"name":"Institute of Oral Biology, Faculty of Dentistry, University of Oslo , 0372 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirik","family":"Malinen","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, University of Oslo , 0371 Oslo , Norway"},{"name":"Department of Medical Physics, Cancer Clinic, Oslo University Hospital , 0379 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine Merete","family":"S\u00f8land","sequence":"additional","affiliation":[{"name":"Institute of Oral Biology, Faculty of Dentistry, University of Oslo , 0372 Oslo , Norway"},{"name":"Department of Pathology, Oslo University Hospital , 0372 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Jeppesen","family":"Edin","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Sciences, University of Oslo , 0371 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"2023012015494186200_ref1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.semradonc.2017.04.008","article-title":"Management of radiation toxicity in head and neck cancers","volume":"27","author":"Siddiqui","year":"2017","journal-title":"Semin Radiat 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