{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:12Z","timestamp":1787009172144,"version":"build-2736575974"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH017"],"award-info":[{"award-number":["ZR2019MH017"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The radiation-induced inflammatory response is involved in radiation damage to the cochlea and causes sensorineural hearing loss (SNHL). NF-\u03baB, as the master switch of the inflammatory response, regulates the expression of many inflammation-related genes and thus the inflammatory response. Therefore, in this study we used a mouse model to determine whether radiation-induced NF-\u03baB activation is involved in damage to the cochlea and to investigate the underlying mechanism. Eventually, we found that NF-\u03baB was activated after radiation of the cochleae and the activation reached a maximum at 2\u20136\u00a0h after radiation. And morphological analysis showed severe damage to the cochleae after radiation, but this damage was significantly ameliorated by JSH-23 (an inhibitor of NF-\u03baB) pretreatment. Along with these morphological changes, the expression levels of proinflammatory molecules (including proinflammatory cytokines IL-6, TNF-\u03b1, COX-2 and inflammation-related proteins VCAM-1, MIP-1\u03b2) in the cochlear tissues were significantly increased after radiation, but were significantly decreased by JSH-23 pretreatment compared to radiation alone. Therefore, these results indicated that radiation-induced NF-\u03baB activation was involved in damage to the cochleae and resultant SNHL via its promotion of the inflammatory response mediated by overexpression of some proinflammatory molecules in cochlear tissues, and inhibition of radiation-induced NF-\u03baB was conducive to preventing such damage.<\/jats:p>","DOI":"10.1093\/jrr\/rrac068","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T17:07:23Z","timestamp":1663693643000},"page":"63-72","source":"Crossref","is-referenced-by-count":9,"title":["Radiation-induced NF-\u03baB activation is involved in cochlear damage in mice via promotion of a local inflammatory response"],"prefix":"10.1093","volume":"64","author":[{"given":"Jiaojiao","family":"Tong","sequence":"first","affiliation":[{"name":"Cancer Center, the Second Hospital of Shandong University , Jinan, Shandong Province 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Cancer Center, the Second Hospital of Shandong University , Jinan, Shandong Province 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Cancer Center, the Second Hospital of Shandong University , Jinan, Shandong Province 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center, the Second Hospital of Shandong University , Jinan, Shandong Province 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianshui","family":"Sun","sequence":"additional","affiliation":[{"name":"Cancer Center, the Second Hospital of Shandong University , Jinan, Shandong Province 250033, 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