{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:59:08Z","timestamp":1791277148582,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"QST President's Strategic Fund Advanced Study Laboratory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We compared the dose distributions of carbon-ion pencil beam scanning (C-PBS), proton pencil beam scanning (P-PBS) and Volumetric Modulated Arc Therapy (VMAT) for locally recurrent rectal cancer.<\/jats:p>\n               <jats:p>The C-PBS treatment planning computed tomography (CT) data sets of 10 locally recurrent rectal cancer cases were randomly selected. Three treatment plans were created using identical prescribed doses. The beam angles for C-PBS and P-PBS were identical. Dosimetry, including the dose received by 95% of the planning target volume (PTV) (D95%), dose to the 2\u00a0cc receiving the maximum dose (D2cc), organ at risk (OAR) volume receiving &amp;gt; 15Gy (V15) and\u2009&amp;gt;\u200930Gy (V30), was evaluated. Statistical significance was assessed using the Wilcoxon signed-rank test. Mean PTV-D95% values were\u2009&amp;gt;\u200995% of the volume for P-PBS and C-PBS, whereas that for VMAT was 94.3%. However, PTV-D95% values in P-PBS and VMAT were\u2009&amp;lt;\u200995% in five and two cases, respectively, due to the OAR dose reduction. V30 and V15 to the rectum\/intestine for C-PBS (V30\u2009=\u20094.2\u2009\u00b1\u20093.2\u00a0cc, V15\u2009=\u200913.8\u2009\u00b1\u200910.6\u00a0cc) and P-PBS (V30\u2009=\u20097.3\u2009\u00b1\u20095.6\u00a0cc, V15\u2009=\u200921.3\u2009\u00b1\u200913.5\u00a0cc) were significantly lower than those for VMAT (V30\u2009=\u200917.1\u2009\u00b1\u200910.6\u00a0cc, V15\u2009=\u200955.2\u2009\u00b1\u200928.6\u00a0cc). Bladder-V30 values with P-PBS\/C-PBS (3.9\u2009\u00b1\u20094.8\u00a0Gy(RBE)\/3.0\u2009\u00b1\u20094.0\u00a0Gy(RBE)) were significantly lower than those with VMAT (7.9\u2009\u00b1\u20098.1\u00a0Gy). C-PBS provided superior dose conformation and lower OAR doses compared with P-PBS and VMAT. C-PBS may be the best choice for cases in which VMAT and P-PBS cannot satisfy dose constraints. C-PBS could be another choice for cases in which VMAT and P-PBS cannot satisfy dose constraints, thereby avoiding surgical resection.<\/jats:p>","DOI":"10.1093\/jrr\/rrac074","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T10:29:40Z","timestamp":1668940180000},"page":"162-170","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of dosimetries of carbon-ion pencil beam scanning, proton pencil beam scanning and volumetric modulated arc therapy for locally recurrent rectal cancer"],"prefix":"10.1093","volume":"64","author":[{"given":"Shinichiro","family":"Mori","sequence":"first","affiliation":[{"name":"National Institutes for Quantum Science and Technology , Quantum Life and Medical Science Directorate, , Inage-ku, Chiba 263-8555 , Japan"},{"name":"Institute for Quantum Medical Science , Quantum Life and Medical Science Directorate, , Inage-ku, Chiba 263-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapesh","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tata Medical Center , 14, MAR(E-W), DH Block (Newtown), Action Area I, Newtown, Kolkata, West Bengal 700160 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Accelerator Engineering Corporation , Inage-Ku, Chiba, 263-0043 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tohyama","sequence":"additional","affiliation":[{"name":"Division of Medical Physics, Tokyo Bay Makuhari Clinic for Advanced Imaging, Cancer Screening, and High-Precision Radiotherapy , Mihama-ku, Chiba, 261-0024m Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nomoto","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology, QST Hospital , Inage-ku, Chiba 263-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Shinoto","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology, QST Hospital , Inage-ku, Chiba 263-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Takiyama","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology, QST Hospital , Inage-ku, Chiba 263-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Yamada","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology, QST Hospital , Inage-ku, Chiba 263-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"2023012015494888900_ref1","volume-title":"World Cancer Report 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