{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T18:37:58Z","timestamp":1743273478081},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to assess the severity of acute radiodermatitis (ARD) by ultrasound quantitative parameters and to try to identify the influencing factors of skin toxicity. A total of 55 patients who underwent radiotherapy after unilateral breast-conserving surgery (BCS) were included in the study. The irradiated side of the breast was used as the research object and the quantitative ultrasound parameters (skin thickness, shear wave elasticity) were evaluated before radiotherapy, every week during radiotherapy. Two weeks after radiotherapy, the patients were divided into two groups, according to the World Health Organization scoring standard: mild (0\u20132 grade) and severe (3\u20134 grade). The differences in the parameters between the groups and the changes during radiotherapy were compared, and the relationship between these parameters and the severity of ARD was analyzed. In addition, some clinical factors that may affect ARD were also included in our study. Ninety-eight percent of patients developed different degrees of ARD, and Group 2 accounted for ~31%. At the end of 5\u00a0weeks of radiotherapy, the difference in thickness between the two groups was statistically significant (P\u2009&amp;lt;\u20090.05). There was no significant change in the elastic modulus of breast skin between the two groups (P\u2009&amp;gt;\u20090.05). Body mass index\u2009&amp;gt;25\u00a0kg\/m2, breast thickness\u2009\u226518\u00a0mm, skin basic elastic modulus &amp;lt;23\u00a0kPa and skin thickness increment &amp;gt;0.3\u00a0mm were considered to be associated with severe skin reactions (P\u2009&amp;lt;\u20090.05). Ultrasound can be a useful tool for the non-invasive and objective assessment of skin changes during radiotherapy, documenting quantitative changes in the skin of breast cancer patients following BCS undergoing radiotherapy.<\/jats:p>","DOI":"10.1093\/jrr\/rrad029","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T14:02:26Z","timestamp":1683554546000},"page":"574-581","source":"Crossref","is-referenced-by-count":3,"title":["The role of ultrasound quantitative parameters in the assessment of acute radiodermatitis after breast-conserving surgery"],"prefix":"10.1093","volume":"64","author":[{"given":"Wenqin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"2023052613395246000_ref1","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1245\/s10434-021-09591-x","article-title":"Survival of breast-conserving surgery plus radiotherapy versus total mastectomy in early breast cancer","volume":"28","author":"Kim","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"2023052613395246000_ref2","first-page":"1615","article-title":"An exploratory study of radiation dermatitis in breast cancer patients","volume":"38","author":"Alexopoulou","year":"2018","journal-title":"Anticancer 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