{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:46:33Z","timestamp":1787240793445,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21\u00a0K04943"],"award-info":[{"award-number":["21\u00a0K04943"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The liver\u2019s susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate \u03b3-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5\u00a0Gy)\/high-dose-rate (1.2\u00a0Gy\/min) irradiation on combined oxidative stressors\u2014liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose\/high-dose-rate (especially 0.5\u00a0Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose\/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose\/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range.<\/jats:p>","DOI":"10.1093\/jrr\/rrad030","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T15:00:59Z","timestamp":1684508459000},"page":"635-643","source":"Crossref","is-referenced-by-count":3,"title":["Effects of low-dose\/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice"],"prefix":"10.1093","volume":"64","author":[{"given":"Shota","family":"Naoe","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University , 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University , 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaito","family":"Murakami","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University , 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Yukimine","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University , 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University , 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558 , 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