{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:08:25Z","timestamp":1740136105347,"version":"3.37.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008883","name":"Nagoya City University","doi-asserted-by":"publisher","award":["2213003"],"award-info":[{"award-number":["2213003"]}],"id":[{"id":"10.13039\/501100008883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We aimed to examine outcomes and toxicities of intensity-modulated radiation therapy (IMRT) with the central shielding (CS) technique for patients with uterine cervical cancer. This retrospective study included 54 patients with International Federation of Gynecology and Obstetrics IB-IVA cancer. Whole pelvic radiotherapy or extended-field radiotherapy were performed at the dose of 50.4\u00a0Gy in 28 fractions with helical tomotherapy (HT). Six patients had para-aortic lymph node metastases. The CS technique with HT was utilized after a total dose of 28.8\u201341.4\u00a0Gy to reduce doses to the rectum and bladder. The prescribed dose of intracavitary brachytherapy was mainly 18\u201324\u00a0Gy in three or four fractions at point A. Concurrent chemotherapy was used for 47 patients (87%). Median follow-up time was 56\u00a0months. Seventeen patients (31%) developed recurrence. The recurrence of the cervix was observed in two patients (4%). The 5-year rates of the locoregional control, progression-free survival (PFS) and overall survival were 79, 66 and 82%, respectively. Among several factors evaluated, histological type of adenocarcinoma was only a significantly worse prognostic factor for PFS by multivariate analysis (hazard ratio, 4.9 [95% confidence interval, 1.3\u201318], P\u2009=\u20090.018). Grade 2 or higher late toxicities were observed in nine patients (17%). Two patients (4%) each had grade 3 proctitis and grade 3 ileus, respectively. No grade 4 toxicity or treatment-related death was observed. The results suggest that IMRT with the CS technique allows a high local control without increasing the risk of complications for cervical cancer patients.<\/jats:p>","DOI":"10.1093\/jrr\/rrad039","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:01:18Z","timestamp":1686880878000},"page":"720-727","source":"Crossref","is-referenced-by-count":0,"title":["Intensity-modulated radiation therapy with the central shielding technique for patients with uterine cervical cancer"],"prefix":"10.1093","volume":"64","author":[{"given":"Akira","family":"Torii","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuo","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ichinomiya Municipal Hospital , 2-2-22 Bunkyo, Ichinomiya, Aichi 491-8558 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kasugai Municipal Hospital , 1-1-1 Takaki-cho, Kasugai, Aichi 486-8510 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Konan Kosei Hospital , 137 Ohmatsubara, Takaya-cho, Konan, Aichi 483-8704 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanari","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Murao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ichinomiya Municipal Hospital , 2-2-22 Bunkyo, Ichinomiya, Aichi 491-8558 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kasugai Municipal Hospital , 1-1-1 Takaki-cho, Kasugai, Aichi 486-8510 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Hiwatashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University Hospital , 1 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