{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:07:05Z","timestamp":1791378425731,"version":"4.3.2"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24890018"],"award-info":[{"award-number":["24890018"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26860973"],"award-info":[{"award-number":["26860973"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This prospective study aimed to evaluate whether radiation (RT)-induced myocardial damage by cardiac magnetic resonance (CMR) imaging could be a predictor of cardiac events after chemoradiotherapy (CRT) for esophageal cancer and determine the dose-volume histogram (DVH) parameters of the left ventricle (LV) in predicting cardiac events. CMR imaging was performed before and 6\u00a0months after CRT in patients receiving definitive CRT. RT-induced myocardial damage was defined as abnormal CMR findings indicating myocardial fibrosis corresponding to an isodose line of \u226530\u00a0Gy. The cutoff values of the LV DVH parameters were calculated using the receiver operating characteristic curve based on the presence of RT-induced myocardial damage. The prognostic factors related to cardiac events of Grade 3 or higher were examined. Twenty-three patients were enrolled in the study. RT-induced myocardial damage by late gadolinium enhancement and\/or an increase of 100\u00a0ms or higher in native T1 post-CRT was detected in 10 of the 23 patients. LV V45 was the best predictive factor for RT-induced myocardial damage with a cutoff value of 2.1% and an area under the curve of 0.75. The median follow-up period was 82.1\u00a0months. The 5- and 7-year cumulative incidences of cardiac events of Grade 3 or higher were 14.7 and 22.4%, respectively. RT-induced myocardial damage and LV V45 were significant risk factors (P\u2009=\u20090.015 and P\u2009=\u20090.013, respectively). RT-induced myocardial damage is a significant predictor of cardiac events. LV V45 is associated with RT-induced myocardial damage and subsequent cardiac events.<\/jats:p>","DOI":"10.1093\/jrr\/rrad040","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T16:42:29Z","timestamp":1686242549000},"page":"702-710","source":"Crossref","is-referenced-by-count":12,"title":["Clinical impact of radiation-induced myocardial damage detected by cardiac magnetic resonance imaging and dose-volume histogram parameters of the left ventricle as prognostic factors of cardiac events after chemoradiotherapy for esophageal cancer"],"prefix":"10.1093","volume":"64","author":[{"given":"Rei","family":"Umezawa","sequence":"first","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Radiation Oncology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ota","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Diagnostic Radiology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Takagi","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Diagnostic Radiology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Radiation Oncology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Radiation Oncology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"},{"name":"Komazawa University Department of Radiological Sciences, , 1-23-1, Setagayaku, Tokyo, 154-8525 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Radiation Oncology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Radiation Oncology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Takase","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Diagnostic Radiology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Jingu","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Department of Radiation Oncology, , 1-1, Seiryou-machi, Aobaku, Sendai, 980-8574 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"2023071910575423900_ref1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ijrobp.2009.02.086","article-title":"Prospective comparison of surgery alone and chemoradiotherapy with selective surgery in resectable squamous cell carcinoma of the esophagus","volume":"75","author":"Ariga","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2023071910575423900_ref2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/bjs.9437","article-title":"Propensity score analysis of oesophageal cancer treatment with surgery or definitive 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