{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:37:16Z","timestamp":1785476236076,"version":"3.56.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["399825"],"award-info":[{"award-number":["399825"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Radiation therapy (RT) is the primary treatment for many cancers, but its effectiveness is reduced due to radioresistance and side effects. The study aims to investigate an emerging treatment for cancer, cold atmospheric plasma (CAP), as a selectable treatment between cancerous and healthy cells and its role in the occurrence of photodynamic therapy (PDT) utilizing indocyanine green (ICG) as a photosensitizer. We examined whether the efficiency of radiotherapy could be improved by combining CAP with ICG. The PDT effect induced by cold plasma irradiation and the radiosensitivity of ICG were investigated on DFW and HFF cell lines. Then, for combined treatment, ICG was introduced to the cells and treated with radiotherapy, followed by cold plasma treatment simultaneously and 24-h intervals. MTT and colony assays were used to determine the survival of treated cells, and flow cytometry was used to identify apoptotic cells. Despite a decrease in the survival of melanoma cells in CAP, ICG did not affect RT. Comparing the ICG\u2009+\u2009CAP group with CAP, a significant reduction in cell survival was observed, confirming the photodynamic properties of plasma utilizing ICG. The treatment outcome depends on the duration of CAP. The results for healthy and cancer cells also confirmed the selectivity of plasma function. Moreover, cold plasma sensitized melanoma cells to radiotherapy, increasing treatment efficiency. Treatment of CAP with RT can be effective in treating melanoma. The inclusion of ICG results in plasma treatment enhancement. These findings help to select an optimal strategy for a combination of plasma and radiotherapy.<\/jats:p>","DOI":"10.1093\/jrr\/rrad042","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:01:11Z","timestamp":1692230471000},"page":"751-760","source":"Crossref","is-referenced-by-count":6,"title":["Increased radiosensitivity of melanoma cells through cold plasma pretreatment mediated by ICG"],"prefix":"10.1093","volume":"64","author":[{"given":"Sara","family":"Momeni","sequence":"first","affiliation":[{"name":"Department of Medical Physics , School of Medicine, , Isfahan 8174673461 , Iran"},{"name":"Isfahan University of Medical Sciences , School of Medicine, , Isfahan 8174673461 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Shanei","sequence":"additional","affiliation":[{"name":"Department of Medical Physics , School of Medicine, , Isfahan 8174673461 , Iran"},{"name":"Isfahan University of Medical Sciences , School of Medicine, , Isfahan 8174673461 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Sazgarnia","sequence":"additional","affiliation":[{"name":"Department of Medical Physics , Medical Physics Research Center, , Mashhad 9177948564 , Iran"},{"name":"Mashhad University of Medical Sciences , Medical Physics Research Center, , Mashhad 9177948564 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasool","family":"Azmoonfar","sequence":"additional","affiliation":[{"name":"Department of Medical Physics , School of Medicine, , Isfahan 8174673461 , Iran"},{"name":"Isfahan University of Medical Sciences , School of Medicine, , Isfahan 8174673461 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Radiology, Faculty of Medicine, Gonabad University of Medical Sciences , Gonabad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"2023092301011938800_ref1","doi-asserted-by":"crossref","first-page":"12086","DOI":"10.1021\/acsnano.1c03416","article-title":"Visible-light-triggered prodrug nanoparticles combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy","volume":"15","author":"Choi","year":"2021","journal-title":"ACS Nano"},{"key":"2023092301011938800_ref2","doi-asserted-by":"crossref","first-page":"15600","DOI":"10.1002\/ange.202103015","article-title":"ZIF-based nanoparticles combine X-ray-induced nitrosative stress with autophagy management for hypoxic prostate cancer therapy","volume":"133","author":"Li","year":"2021","journal-title":"Angew Chem"},{"key":"2023092301011938800_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2021.05.012","article-title":"The reversal of chemotherapy-induced 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