{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:19:08Z","timestamp":1786544348011,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03021"],"award-info":[{"award-number":["22H03021"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16757"],"award-info":[{"award-number":["20K16757"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The purpose of this study was to retrospectively assess target localization accuracy across different soft-tissue matching protocols using cone-beam computed tomography (CBCT) in a large sample of patients with pancreatic cancer and to estimate the optimal margin size for each protocol. Fifty-four consecutive patients with pancreatic cancer who underwent 15-fraction volumetric modulated arc therapy under the end-exhalation breath-hold condition were enrolled. Two soft-tissue matching protocols were used according to the resectability classification, including gross tumor volume (GTV) matching for potentially resectable tumors and planning target volume (PTV) matching for borderline resectable or unresectable tumors. The tolerance of the target localization error in both matching protocols was set to 5\u00a0mm in any direction. The optimal margin size for each soft-tissue matching protocol was calculated from the systematic and random errors of the inter- and intrafraction positional variations using the van Herk formula. The inter- and intrafraction positional variations of PTV matching were smaller than those of GTV matching. The percentage of target localization errors exceeding 5\u00a0mm in the first CBCT scan of each fraction in the superior\u2013inferior direction was 12.6 and 4.8% for GTV and PTV matching, respectively. The optimal margin sizes for GTV and PTV matching were 3.7 and 2.7, 5.4 and 4.1 and 3.9 and 3.0\u00a0mm in the anterior\u2013posterior, superior\u2013inferior and left\u2013right directions, respectively. Target localization accuracy in PTV matching was higher than that in GTV matching. By setting the tolerance of the target localization error, treatment can be successful within the planned margin size.<\/jats:p>","DOI":"10.1093\/jrr\/rrad048","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:20:14Z","timestamp":1687220414000},"page":"711-719","source":"Crossref","is-referenced-by-count":2,"title":["Assessing target localization accuracy across different soft-tissue matching protocols using end-exhalation breath-hold cone-beam computed tomography in patients with pancreatic cancer"],"prefix":"10.1093","volume":"64","author":[{"given":"Makoto","family":"Sasaki","sequence":"first","affiliation":[{"name":"Division of Clinical Radiology Service, Kyoto University Hospital , 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Information Technology and Medical Engineering, Human Health Sciences , Graduate School of Medicine, , 53 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8397 , Japan"},{"name":"Kyoto University , Graduate School of Medicine, , 53 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8397 , Japan"},{"name":"Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine , 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto University, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ashida","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine , 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto University, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Nakata","sequence":"additional","affiliation":[{"name":"Division of Clinical Radiology Service, Kyoto University Hospital , 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine , 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto University, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine , 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto University, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"2023071910573675000_ref1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.6004\/jnccn.2021.0017","article-title":"Pancreatic adenocarcinoma, version 2.2021, NCCN clinical practice guidelines in oncology","volume":"19","author":"Tempero","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"key":"2023071910573675000_ref2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.annonc.2021.01.006","article-title":"European cancer mortality predictions for the year 2021 with focus on pancreatic and female lung cancer","volume":"32","author":"Carioli","year":"2021","journal-title":"Ann Oncol"},{"key":"2023071910573675000_ref3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s11912-013-0366-9","article-title":"Resectable, borderline resectable, and locally advanced pancreatic cancer: what does it matter?","volume":"16","author":"Halperin","year":"2014","journal-title":"Curr Oncol Rep"},{"key":"2023071910573675000_ref4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13014-019-1277-1","article-title":"Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy","volume":"14","author":"Hall","year":"2019","journal-title":"Radiat Oncol"},{"key":"2023071910573675000_ref5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12885-022-09244-6","article-title":"Impact of neoadjuvant intensity-modulated radiation therapy on borderline resectable pancreatic cancer with arterial abutment; a prospective, open-label, phase II study in a single institution","volume":"22","author":"Masui","year":"2022","journal-title":"BMC Cancer"},{"key":"2023071910573675000_ref6","article-title":"Search Portal. 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