{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:12:14Z","timestamp":1767183134641,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21 K07692"],"award-info":[{"award-number":["JP21 K07692"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In external radiotherapy of head and neck (HN) cancers, the reduction of irradiation accuracy due to HN volume reduction often causes a problem. Adaptive radiotherapy (ART) can effectively solve this problem; however, its application to all cases is impractical because of cost and time. Therefore, finding priority cases is essential. This study aimed to predict patients with HN cancers are more likely to need ART based on a quantitative measure of large HN volume reduction and evaluate model accuracy. The study included 172 cases of patients with HN cancer who received external irradiation. The HN volume was calculated using cone-beam computed tomography (CT) for irradiation-guided radiotherapy for all treatment fractions and classified into two groups: cases with a large reduction in the HN volume and cases without a large reduction. Radiomic features were extracted from the primary gross tumor volume (GTV) and nodal GTV of the planning CT. To develop the prediction model, four feature selection methods and two machine-learning algorithms were tested. Predictive performance was evaluated by the area under the curve (AUC), accuracy, sensitivity and specificity. Predictive performance was the highest for the random forest, with an AUC of 0.662. Furthermore, its accuracy, sensitivity and specificity were 0.692, 0.700 and 0.813, respectively. Selected features included radiomic features of the primary GTV, human papillomavirus in oropharyngeal cancer and the implementation of chemotherapy; thus, these features might be related to HN volume change. Our model suggested the potential to predict ART requirements based on HN volume reduction .<\/jats:p>","DOI":"10.1093\/jrr\/rrad052","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T13:56:18Z","timestamp":1689774978000},"page":"783-794","source":"Crossref","is-referenced-by-count":4,"title":["Development of a prediction model for head and neck volume reduction by clinical factors, dose\u2013volume histogram parameters and radiomics in head and neck cancer"],"prefix":"10.1093","volume":"64","author":[{"given":"Miyu","family":"Ishizawa","sequence":"first","affiliation":[{"name":"Department of Radiological Technology , Faculty of Medicine, , 21 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 , Japan"},{"name":"School of Health Sciences, Tohoku University , Faculty of Medicine, , 21 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine , 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisamichi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology , Faculty of Medicine, , 21 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 , Japan"},{"name":"School of Health Sciences, Tohoku University , Faculty of Medicine, , 21 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kadoya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine , 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyokazu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiation Technology , Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine , 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Jingu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine , 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine , 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574 , Japan"},{"name":"Department of Radiological Technology , Faculty of Medicine, , 21 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 , Japan"},{"name":"School of Health Sciences, Tohoku University , Faculty of Medicine, , 21 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"2023092301014653700_ref1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s11136-010-9688-3","article-title":"Quality of life for head and neck cancer patients treated by combined modality therapy: the therapeutic benefit of technological advances in radiotherapy","volume":"19","author":"Huang","year":"2010","journal-title":"Qual Life 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prospective observational study","volume":"76","author":"Bhide","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2023092301014653700_ref5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1186\/1471-2407-13-548","article-title":"Predictors for replanning in loco-regionally advanced nasopharyngeal carcinoma patients undergoing intensity-modulated radiation therapy: a prospective observational study","volume":"13","author":"Yan","year":"2013","journal-title":"BMC Cancer"},{"key":"2023092301014653700_ref6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2008.07.006","article-title":"Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration","volume":"89","author":"Lee","year":"2008","journal-title":"Radiother 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