{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:07:23Z","timestamp":1790737643089,"version":"4.1.0"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073477"],"award-info":[{"award-number":["82073477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Fund for Distinguished Young Scholars in Sichuan Province","award":["2022JDJQ0051"],"award-info":[{"award-number":["2022JDJQ0051"]}]},{"name":"Xuzhou Key Research & Development Program Project","award":["KC22111"],"award-info":[{"award-number":["KC22111"]}]},{"name":"Xuzhou Health and Health Commission Youth Innovation Science and Technology Project","award":["XWKYHT20220073"],"award-info":[{"award-number":["XWKYHT20220073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Radiotherapy (RT) has been the standard of care for treating a multitude of cancer types. Radiation-induced gastric injury (RIGI) is a common complication of RT for thoracic and abdominal tumors. It manifests acutely as radiation gastritis or gastric ulcers, and chronically as chronic atrophic gastritis or intestinal metaplasia. In recent years, studies have shown that intracellular signals such as oxidative stress response, p38\/MAPK pathway and transforming growth factor-\u03b2 signaling pathway are involved in the progression of RIGI. This review also summarized the risk factors, diagnosis and treatment of this disease. However, the root of therapeutic challenges lies in the incomplete understanding of the mechanisms. Here, we also highlight the potential mechanistic, diagnostic and therapeutic directions of RIGI.<\/jats:p>","DOI":"10.1093\/jrr\/rrad071","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:41:47Z","timestamp":1696369307000},"page":"870-879","source":"Crossref","is-referenced-by-count":16,"title":["Radiation-induced gastric injury during radiotherapy: molecular mechanisms and clinical treatment"],"prefix":"10.1093","volume":"64","author":[{"given":"Guangxia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First People\u2019s Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University , Xuzhou 221200 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Medicine , West China School of Basic Medical Sciences and Forensic Medicine, , Chengdu 610041 , China"},{"name":"Sichuan University , West China School of Basic Medical Sciences and Forensic Medicine, , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Medicine , West China School of Basic Medical Sciences and Forensic Medicine, , Chengdu 610041 , China"},{"name":"Sichuan University , West China School of Basic Medical Sciences and Forensic Medicine, , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First People\u2019s Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University , Xuzhou 221200 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First People\u2019s Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University , Xuzhou 221200 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Medicine , West China School of Basic Medical Sciences and Forensic Medicine, , Chengdu 610041 , China"},{"name":"Sichuan University , West China School of Basic Medical Sciences and Forensic Medicine, , Chengdu 610041 , China"},{"name":"Department of Nuclear Medicine, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital , Chengdu 610051, China"},{"name":"NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital) , Mianyang 621099 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"2023112303340341400_ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2023112303340341400_ref2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1667\/RR15489.1","article-title":"The radiation-induced bystander effect (RIBE) and its connections with the hallmarks of cancer","volume":"192","author":"Heeran","year":"2019","journal-title":"Radiat Res"},{"key":"2023112303340341400_ref3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1269\/jrr.07058","article-title":"Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-Mura 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