{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:08:38Z","timestamp":1740136118845,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["2022\u2013A\u201318"],"award-info":[{"award-number":["2022\u2013A\u201318"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["23ck0106745h0002"],"award-info":[{"award-number":["23ck0106745h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The uterus is known as one of the moving organs. We evaluated the movement of the uterus during irradiation and the effects of changes in the surrounding organs using a magnetic resonance (MR)-guided radiotherapy system. Seven patients with cervical cancer underwent pre- and posttreatment MR imaging to assess changes in the positioning of the uterus and cervix as well as the alterations in bladder and rectal volume. The study revealed that the movements of the uterus were greater than that of the cervix and showed a tendency to correlate with the bladder rather than the rectum. We also examined whether intrafractional motion could lead to insufficient dose coverage of the clinical target volume (CTV), specifically focusing on the D98% of the CTV in the uterine body and cervix. The impact of intrafractional motion on the D98% varied among patients, with one out of the seven patients experiencing an average dosimetric change of \u22122.6\u00a0Gy in the uterus, although larger planning target volume margins of 1.5\u00a0cm were applied, therefore, indicating the need for individualized optimal margins in each case. Online adaptive radiotherapy offers the advantage of modifying the treatment plan when irradiating moving organs, such as the uterus. However, it should be noted that this approach may result in longer overall treatment times compared with the traditional methods. Therefore, we must carefully consider the influence of intrafractional organ motions when opting for such a treatment.<\/jats:p>","DOI":"10.1093\/jrr\/rrad072","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:32:29Z","timestamp":1696991549000},"page":"967-972","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of intrafractional motion of the cervix\u2013uterus by MR-guided radiotherapy system"],"prefix":"10.1093","volume":"64","author":[{"given":"Ayaka","family":"Nagao","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Radiation Safety and Quality Assurance Division , Common Department, , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"},{"name":"National Cancer Center Hospital , Common Department, , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Radiation Safety and Quality Assurance Division , Common Department, , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"},{"name":"National Cancer Center Hospital , Common Department, , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Chiba","sequence":"additional","affiliation":[{"name":"Radiation Safety and Quality Assurance Division , Common Department, , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"},{"name":"National Cancer Center Hospital , Common Department, , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Fujiyama","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Sakasai","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tairo","family":"Kashihara","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department 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