{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:30:28Z","timestamp":1770881428916,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grant-in-Aid for Research on Radiation Oncology","award":["23\u00a0K14857"],"award-info":[{"award-number":["23\u00a0K14857"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5\u20137.5\u00a0cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker. This study aimed to investigate stereotactic body radiotherapy (SBRT) outcomes of primary liver tumors treated with SyncTraX in cases where the isocenter was shifted marginally or outside the planning target volume (PTV). Twelve patients with 13 liver tumors were included in the analysis. Their isocenter was shifted toward the marker and was placed marginally or outside the PTV. The prescribed doses were generally 40\u00a0Gy in four fractions or 48\u00a0Gy in eight fractions. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan\u2013Meier method. All patients completed the scheduled SBRT. The median distance between the fiducial marker and PTV centroid was 56.0 (interquartile range [IQR]: 52.7\u201366.7) mm. By shifting the isocenter toward the marker, the median distance between the marker and isocenter decreased to 34.0 (IQR: 33.4\u201339.7) mm. With a median follow-up period of 25.3 (range: 6.9\u201370.0) months, the 2-year OS and LC rates were 100.0% (95% confidence interval: 100\u2013100). An isocenter shift makes SBRT with SyncTraX feasible in cases where the fiducial marker is distant from the tumor.<\/jats:p>","DOI":"10.1093\/jrr\/rrad088","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T01:58:51Z","timestamp":1700791131000},"page":"92-99","source":"Crossref","is-referenced-by-count":1,"title":["Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift"],"prefix":"10.1093","volume":"65","author":[{"given":"Yusuke","family":"Uchinami","sequence":"first","affiliation":[{"name":"Hokkaido University Faculty of Medicine and Graduate School of Medicine Department of Radiation Oncology, , North 15 West 7, Kita-ku, Sapporo 060-8638, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Department of Medical Physics, , North 14 West 5, Kita-ku, Sapporo 060-8648, Japan"},{"name":"Hokkaido University Faculty of Engineering Division of Applied Quantum Science and Engineering, , North 13 West 8, Kita-ku, Sapporo 060-8628, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Abo","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Department of Diagnostic and Interventional Radiology, , North 14 West 5, Kita-ku, Sapporo 060-8648, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Morita","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Department of Diagnostic and Interventional Radiology, , North 14 West 5, Kita-ku, Sapporo 060-8648, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Hokkaido University Faculty of Medicine Department of Gastroenterology and Hepatology, , North 15 West 7, Kita-ku, Sapporo 060-8638, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Kakisaka","sequence":"additional","affiliation":[{"name":"Hokkaido University Faculty of Medicine Department of Gastroenterological Surgery, , North 15 West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Department of Medical Physics, , North 14 West 5, Kita-ku, Sapporo 060-8648, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Department of Radiation Oncology, , North 14 West 5, Kita-ku, Sapporo 060-8648, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Department of Radiation Oncology, , North 14 West 5, Kita-ku, Sapporo 060-8648, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Katoh","sequence":"additional","affiliation":[{"name":"Hokkaido University Faculty of Medicine and Graduate School of Medicine Department of Radiation Oncology, , North 15 West 7, Kita-ku, Sapporo 060-8638, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Hokkaido University Faculty of Medicine and Graduate School of Medicine Department of Radiation Oncology, , North 15 West 7, Kita-ku, Sapporo 060-8638, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"2024012223381565800_ref1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/hepr.13595","article-title":"Multicenter prospective study of stereotactic body radiotherapy for previously untreated solitary primary hepatocellular carcinoma: the STRSPH study","volume":"51","author":"Kimura","year":"2020","journal-title":"Hepatol Res"},{"key":"2024012223381565800_ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejca.2020.04.024","article-title":"Long term outcomes of stereotactic body radiation therapy for hepatocellular carcinoma without macrovascular invasion","volume":"134","author":"Mathew","year":"2020","journal-title":"Eur J Cancer"},{"key":"2024012223381565800_ref3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1186\/s12885-017-3788-1","article-title":"Stereotactic body radiotherapy (SBRT) for locally advanced intrahepatic and extrahepatic cholangiocarcinoma","volume":"17","author":"Gkika","year":"2017","journal-title":"BMC Cancer"},{"key":"2024012223381565800_ref4","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.7150\/jca.13032","article-title":"Stereotactic body radiotherapy (SBRT) for intrahepatic and hilar cholangiocarcinoma","volume":"6","author":"Mahadevan","year":"2015","journal-title":"J Cancer"},{"key":"2024012223381565800_ref5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijrobp.2017.12.288","article-title":"Local control after stereotactic body radiation therapy for liver tumors","volume":"110","author":"Ohri","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024012223381565800_ref6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jhep.2020.03.005","article-title":"Stereotactic body radiation therapy vs. radiofrequency ablation in Asian patients with hepatocellular carcinoma","volume":"73","author":"Kim","year":"2020","journal-title":"J Hepatol"},{"key":"2024012223381565800_ref7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13014-019-1300-6","article-title":"Clinical impact of removing respiratory motion during liver SABR","volume":"14","author":"Gargett","year":"2019","journal-title":"Radiat 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