{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:42:01Z","timestamp":1790563321981,"version":"4.1.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exposure to ionizing radiation can induce harmful biological effects on the human body, particularly in cases of high-dose \u03b3-irradiation affecting the gastrointestinal tract, bone marrow, skin and lung. Such exposures lead to lethal outcomes as individuals experience a breakdown in their immune system\u2019s ability to defend against pathogens, predisposing them to sepsis-induced multiple organ failures. Mesenchymal stromal\/stem cells (MSCs) possess diverse biological characteristics, including immunomodulation, anti-inflammation and tissue regeneration. Off-the-shelf culture-expanded human bone marrow- or adipose tissue-derived MSCs are clinically available to treat graft-versus-host disease following hematopoietic cell transplantation and perianal fistulas in Crohn\u2019s disease in Japan. While preclinical studies showcase encouraging outcomes in radiation-induced injuries, the effectiveness of MSC transplantation in addressing acute radiation syndrome affecting organs in irradiated individuals is limited. Recent studies have highlighted MSC-releasing extracellular vesicles as nanoparticle substances responsible for outlining the mechanism of action and have identified various components, including proteins and microRNA, that serve as functional molecules. MSC-releasing extracellular vesicle-based therapy emerges as a promising avenue, offering a potential solution to the challenges posed by radiation-induced injuries. However, further investigation is required, especially regarding whether MSC-releasing extracellular vesicles have regenerative effects on tissue-resident stem cells. These unresolved issues represent key aspects that need to be addressed to optimize the therapeutic potential of cell-based and extracellular vesicle-based MSC therapies for interventions in the context of radiation-induced injuries.<\/jats:p>","DOI":"10.1093\/jrr\/rrae009","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T13:36:38Z","timestamp":1734356198000},"page":"i80-i87","source":"Crossref","is-referenced-by-count":7,"title":["Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems"],"prefix":"10.1093","volume":"65","author":[{"given":"Yasuo","family":"Miura","sequence":"first","affiliation":[{"name":"Hiroshima University Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553,","place":["Japan"]},{"name":"Fujita Health University School of Medicine Department of Transfusion Medicine and Cell Therapy, , 1-93 Dengakugakubo, Kutsukakecho, Toyoake, Aichi 470-1192,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumie","family":"Fujii","sequence":"additional","affiliation":[{"name":"Fujita Health University School of Medicine Department of Transfusion Medicine and Cell Therapy, , 1-93 Dengakugakubo, Kutsukakecho, Toyoake, Aichi 470-1192,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Hiroshima University Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"2024121613363104500_ref1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1089\/ars.2013.5489","article-title":"Effects of ionizing 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