{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:16:07Z","timestamp":1789215367409,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aim of the present study was to report the feasibility of proton beam reirradiation for patients with locally recurrent rectal cancer (LRRC) with prior pelvic irradiation. The study population included patients who were treated with proton beam therapy (PBT) for LRRC between 2008 and December 2019 in our institution. Those who had a history of distant metastases of LRRC, with or without treatment, before reirradiation, were excluded. Overall survival (OS), progression-free survival (PFS) and local control (LC) were estimated using the Kaplan\u2013Meier method. Ten patients were included in the present study. The median follow-up period was 28.7\u00a0months, and the median total dose of prior radiotherapy (RT) was 50\u00a0Gy (range, 30\u00a0Gy\u201374.8\u00a0Gy). The median time from prior RT to reirradiation was 31.5\u00a0months (range, 8.1\u201396.6\u00a0months), and the median reirradiation dose was 72\u00a0Gy (relative biological effectiveness) (range, 56\u201377\u00a0Gy). The 1-year\/2-year OS, PFS and LC rates were 100%\/60.0%, 20.0%\/10.0% and 70.0%\/58.3%, respectively, with a median survival time of 26.0\u00a0months. Seven patients developed a Grade 1 acute radiation dermatitis, and no Grade\u00a0\u2265\u00a02 acute toxicity was recorded. Grade\u00a0\u2265\u00a03 late toxicity was recorded in only one patient, who had developed a colostomy due to radiation-related intestinal bleeding. Reirradiation using PBT for LRRC patients who had previously undergone pelvic irradiation was feasible. However, the indications for PBT reirradiation for LRRC patients need to be considered carefully due to the risk of severe late GI toxicity.<\/jats:p>","DOI":"10.1093\/jrr\/rrae019","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T22:49:17Z","timestamp":1712875757000},"page":"379-386","source":"Crossref","is-referenced-by-count":15,"title":["Proton beam reirradiation for locally recurrent rectal cancer patients with prior pelvic irradiation"],"prefix":"10.1093","volume":"65","author":[{"given":"Yoshiaki","family":"Takagawa","sequence":"first","affiliation":[{"name":"Fukushima Medical University Department of Minimally Invasive Surgical and Medical Oncology, , Fukushima, Japan"},{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohisa","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Seto","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Azami","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Machida","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Takayama","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Shazrina","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Nakasato","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Murakami","sequence":"additional","affiliation":[{"name":"Southern TOHOKU Proton Therapy Center Department of Radiation Oncology, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michitaka","family":"Honda","sequence":"additional","affiliation":[{"name":"Fukushima Medical University Department of Minimally Invasive Surgical and Medical Oncology, , Fukushima, Japan"},{"name":"Southern TOHOKU General Hospital Department of Surgery, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Teranishi","sequence":"additional","affiliation":[{"name":"Southern TOHOKU General Hospital Department of Surgery, , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kono","sequence":"additional","affiliation":[{"name":"Fukushima Medical University School of Medicine Department of Gastrointestinal Tract Surgery, , Fukushima, 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