{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:11Z","timestamp":1787009171234,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effectiveness of single-fraction 8-Gy radiotherapy for painful bone metastases has been verified in numerous randomized controlled trials. However, few reports have described the effectiveness of single-fraction 8-Gy radiotherapy in painful tumors other than bone metastases. We conducted a retrospective analysis to evaluate the pain response to single-fraction 8-Gy radiotherapy in painful non-bone-metastasis tumors. We included patients who had received single-fraction 8-Gy radiotherapy for such tumors between January 2017 and December 2022, excluding those with brain metastases, hematological tumors and those who received re-irradiation. Pain response assessment was based on the best responses documented in the medical records and conducted by two radiation oncologists. A total of 36 eligible patients were included in this study. The irradiation sites included primary lesions in eight patients, lymph node metastases in eight, muscle metastases in seven, pleural dissemination in four, skin\/subcutaneous metastases in four and other sites in five. Pain response was assessed in 24 patients after radiotherapy. Pain response rate was 88% in evaluable patients; 21 of the 24 patients experienced response. The median assessment date for pain response was 37\u00a0days (range: 8\u2013156\u00a0days) after radiotherapy. Re-irradiation was performed in four patients (11%). Single-fraction 8-Gy radiotherapy seemed to be a promising treatment option for painful non-bone-metastasis tumors and warrants further investigation.<\/jats:p>","DOI":"10.1093\/jrr\/rrae025","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T17:36:49Z","timestamp":1714498609000},"page":"408-412","source":"Crossref","is-referenced-by-count":4,"title":["Pain response in single-fraction 8-Gy radiotherapy for painful non-bone-metastasis tumors: a single-center retrospective study"],"prefix":"10.1093","volume":"65","author":[{"given":"Nobuki","family":"Imano","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology , Graduate School of Biomedical Health Sciences, , 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551 , Japan"},{"name":"Hiroshima University , Graduate School of Biomedical Health Sciences, , 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fujieda Municipal General Hospital , 4-1-11, Surugadai, Fujieda-shi, Shizuoka 426-8677 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fujieda Municipal General Hospital , 4-1-11, Surugadai, Fujieda-shi, Shizuoka 426-8677 , Japan"},{"name":"Department of Radiation Oncology, Hamamatsu University School of Medicine , 1-20-1, Handayama, Chuo-ku, Hamamatsu-shi, Shizuoka 431-3192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ariake Medical Center , 2600, Arao, Arao-shi, Kumamoto 864-0041 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"2024052320114983200_ref1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jpainsymman.2015.12.340","article-title":"Update on prevalence of pain in patients with cancer: systematic review and meta-analysis","volume":"51","author":"Beuken-van Everdingen","year":"2016","journal-title":"J Pain Symptom Manag"},{"key":"2024052320114983200_ref2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.radonc.2018.01.003","article-title":"Update of the systematic review of palliative radiation therapy fractionation for bone metastases","volume":"126","author":"Rich","year":"2018","journal-title":"Radiother Oncol"},{"key":"2024052320114983200_ref3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.radonc.2022.05.024","article-title":"ESTRO ACROP guidelines for external beam radiotherapy of patients with 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