{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:07:19Z","timestamp":1784876839542,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K07715"],"award-info":[{"award-number":["JP21K07715"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The usefulness of moderately hypofractionated radiotherapy for localized prostate cancer has been extensively reported, but there are limited studies on proton beam therapy (PBT) using similar hypofractionation schedules. The aim of this prospective phase II study is to confirm the safety of a shortened PBT course using 70\u00a0Gy relative biological effectiveness (RBE) in 28 fractions. From May 2013 to June 2015, 102 men with localized prostate cancer were enrolled. Androgen deprivation therapy was administered according to risk classification. Toxicity was assessed using Common Terminology Criteria for Adverse Events version 4.0. Of the 100 patients ultimately evaluated, 15 were classified as low risk, 43 as intermediate risk, and 42 as high risk. The median follow-up time of the surviving patients was 96\u00a0months (range: 60\u2013119\u00a0months). The 5-year cumulative incidences of grade 2 gastrointestinal\/genitourinary adverse events were 1% (95% CI: 0.1\u20136.9) and 4% (95% CI: 1.5\u201310.3), respectively; no grade\u2009\u2265\u20093 gastrointestinal\/genitourinary adverse events were observed. The current study revealed a low incidence of late adverse events in prostate cancer patients treated with moderately hypofractionated PBT of 70\u00a0Gy (RBE) in 28 fractions, indicating the safety of this schedule.<\/jats:p>","DOI":"10.1093\/jrr\/rrae026","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T20:35:35Z","timestamp":1715632535000},"page":"402-407","source":"Crossref","is-referenced-by-count":5,"title":["Moderately hypofractionated proton beam therapy for localized prostate cancer: 5-year outcomes of a phase II trial"],"prefix":"10.1093","volume":"65","author":[{"given":"Motohiro","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"},{"name":"QST Hospital, National Institutes for Quantum Science and Technology , 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Sekino","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"},{"name":"JCOG Data Center and Operations Office, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuuo-ku, Tokyo, 104-0045 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine and Graduate School of Comprehensive Human Science, , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"},{"name":"University of Tsukuba , Faculty of Medicine and Graduate School of Comprehensive Human Science, , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology, Toho University Sakura Medical Center , 564-1 Shimoshizu, Sakura, Chiba, 285-8741 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Sugahara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokyo Medical University Ibaraki Medical Center , 3-20-1 Chuuo, Ami-machi, inashiki-gun, Ibaraki, 300-0395 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iizumi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mizumoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ibaraki Prefectural Central Hospital , 6528 Koibuchi, Kasama, Ibaraki, 309-1793 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Keino","sequence":"additional","affiliation":[{"name":"Tsukuba Clinical Research and Development Organization (T-CReDO), University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Iizumi","sequence":"additional","affiliation":[{"name":"Tsukuba Clinical Research and Development Organization (T-CReDO), University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8576 , 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