{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:41:41Z","timestamp":1780407701739,"version":"3.54.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the next decade, the International Commission on Radiological Protection (ICRP) will issue the next set of general recommendations, for which evaluation of relative biological effectiveness (RBE) for various types of tissue reactions would be needed. ICRP has recently classified diseases of the circulatory system (DCS) as a tissue reaction, but has not recommended RBE for DCS. We therefore evaluated the mean and uncertainty of RBE for DCS by applying a microdosimetric kinetic model specialized for RBE estimation of tissue reactions. For this purpose, we analyzed several RBE data for DCS determined by past animal experiments and evaluated the radius of the subnuclear domain best fit to each experiment as a single free parameter included in the model. Our analysis suggested that RBE for DCS tends to be lower than that for skin reactions, and their difference was borderline significant due to large variances of the evaluated parameters. We also found that RBE for DCS following mono-energetic neutron irradiation of the human body is much lower than that for skin reactions, particularly at the thermal energy and around 1\u00a0MeV. This tendency is considered attributable not only to the intrinsic difference of neutron RBE between skin reactions and DCS but also to the difference in the contributions of secondary \u03b3-rays to the total absorbed doses between their target organs. These findings will help determine RBE by ICRP for preventing tissue reactions.<\/jats:p>","DOI":"10.1093\/jrr\/rrae051","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T18:38:01Z","timestamp":1719427081000},"page":"500-506","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of relative biological effectiveness for diseases of the circulatory system based on microdosimetry"],"prefix":"10.1093","volume":"65","author":[{"given":"Tatsuhiko","family":"Sato","sequence":"first","affiliation":[{"name":"Nuclear Science and Engineering Center, Japan Atomic Energy Agency (JAEA) , Shirakata 2-4, Tokai, Ibaraki 319-1195 , Japan"},{"name":"Research Center for Nuclear Physics, Osaka University , Mihogaoka 10-1, Ibaraki, Osaka 567-0047 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsuya","sequence":"additional","affiliation":[{"name":"Nuclear Science and Engineering Center, Japan Atomic Energy Agency (JAEA) , Shirakata 2-4, Tokai, Ibaraki 319-1195 , Japan"},{"name":"Faculty of Health Sciences, Hokkaido University , Kita-12 Nishi-5, Kita-ku, Sapporo, Hokkaido 060-0812 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Hamada","sequence":"additional","affiliation":[{"name":"Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI) , Iwado-kita 2-11-1, Komae, Tokyo 201-8511 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"2024072301313953100_ref1","article-title":"The 2007 recommendations of the international commission on radiological protection. ICRP publication 103","volume":"37","author":"International Commission on Radiological Protection","year":"2007","journal-title":"Ann ICRP"},{"key":"2024072301313953100_ref2","article-title":"Use of dose quantities in radiological protection. ICRP publication 147","volume":"50","author":"International Commission on Radiological Protection","year":"2021","journal-title":"Ann ICRP"},{"key":"2024072301313953100_ref3","volume-title":"Operational Quantities for External Radiation Exposure","author":"International Commission on Radiation Units and Measurements","year":"2020"},{"key":"2024072301313953100_ref4","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1088\/1361-6498\/ac1611","article-title":"Keeping the ICRP recommendations fit for purpose","volume":"41","author":"Clement","year":"2021","journal-title":"J Radiol Prot"},{"key":"2024072301313953100_ref5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijrobp.2022.05.010","article-title":"Microdosimetric modeling of relative biological effectiveness for skin reactions: possible linkage between in vitro and in vivo data","volume":"114","author":"Sato","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024072301313953100_ref6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/095530096145481","article-title":"A microdosimetric-kinetic model of cell death from exposure to ionizing radiation of any LET, with experimental and clinical applications","volume":"69","author":"Hawkins","year":"1996","journal-title":"Int J Radiat Biol"},{"key":"2024072301313953100_ref7","article-title":"RBE for deterministic effects. 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