{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:51:21Z","timestamp":1754153481269,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adult T-cell lymphoma\/leukemia (ATL) is an aggressively malignant peripheral T-cell neoplasm. Only a few studies have reported the use of radiotherapy (RT) for ATL. Therefore, the aim of this study was to clarify the efficacy of RT for ATL. We retrospectively reviewed 90 courses of RT administered to 19 consecutive ATL patients between 2008 and 2023. The subtypes included lymphoma (n\u2009=\u20098), acute (n\u2009=\u20097), smoldering (n\u2009=\u20093) and unknown (n\u2009=\u20091). Ninety lesions (cutaneous\u2009=\u200972, extranodal\u2009=\u200910, nodal\u2009=\u20098) were treated at a mean dose of 39.1\u00a0Gy\/3.2\u00a0Gy (range, 24\u201360\u00a0Gy). Administration of RT for ATL lesions resulted in a combined complete response and partial response rate of 92%. At a mean of 47.5\u00a0months of follow-up (range, 0\u2013102\u00a0months), local recurrence was not observed in 98.9% of the courses. A treatment response in terms of clinical symptoms was observed in 92% of the courses. The median survival time was 918\u00a0days. No acute grade\u2009\u22653 toxicity or any late toxicity was noted. In conclusion, RT was confirmed to be effective and safe for the treatment of local ATL lesions.<\/jats:p>","DOI":"10.1093\/jrr\/rraf036","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T13:09:47Z","timestamp":1752325787000},"page":"423-428","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy for human T-cell leukemia virus type 1\u2013associated adult T-cell leukemia\/lymphoma"],"prefix":"10.1093","volume":"66","author":[{"given":"Kohei","family":"Tokuyama","sequence":"first","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Itaya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoko","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oita Prefectural Hospital , 476 Bunyo, Oita-shi, Oita 870-8511 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashige","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oita Prefectural Hospital , 476 Bunyo, Oita-shi, Oita 870-8511 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yamate","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniko","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oita University Hospital , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Oita University , 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"2025072300414224300_ref1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12325-018-0658-4","article-title":"A review of new findings in adult T-cell Leukemia-lymphoma: a focus on current and emerging treatment strategies","volume":"35","author":"Hermine","year":"2018","journal-title":"Adv Ther"},{"key":"2025072300414224300_ref2","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","article-title":"Global epidemiology of HTLV-I infection and associated diseases","volume":"24","author":"Proietti","year":"2005","journal-title":"Oncogene"},{"key":"2025072300414224300_ref3","volume-title":"Abeloff\u2019s Clinical Oncology","author":"Tsukasaki","year":"2013","edition":"5th"},{"key":"2025072300414224300_ref4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia\u2013lymphoma. 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