{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T12:45:15Z","timestamp":1786193115496,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Project of Zhejiang Chinese Medical University","award":["2023JKZDZ05"],"award-info":[{"award-number":["2023JKZDZ05"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371290"],"award-info":[{"award-number":["32371290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Microplastics (MPs) have been detected in multiple human organs, raising concerns about their potential health risks. The intestinal tract is particularly vulnerable to MPs exposure and accumulation. Radiotherapy often causes side effects such as radiation-induced intestinal injury (RIII). Although previous studies have shown that MPs exacerbate RIII by altering gut microbiota, their effect on the small intestine\u2019s intrinsic sensitivity to radiation remains unclear. In this study, C57BL\/6 mice were preexposed to MPs for a short period and then irradiated with 4 or 10\u00a0Gy to evaluate intestinal injury. Proteomic analysis of small intestine was performed to identify changes in protein expression. Short-term MPs exposure alone caused minimal intestinal damage. While 4\u00a0Gy irradiation did not cause significant intestinal injury, 10\u00a0Gy irradiation induced pronounced inflammation, increased epithelial apoptosis, and disrupted villus and lamina propria architecture. Importantly, the mice preexposed to MPs exhibited significantly increased sensitivity to RIII. Furthermore, prior MPs exposure significantly exacerbated RIII at 4\u00a0Gy but had no obvious influence on RIII at 10\u00a0Gy in C57BL\/6 mice. The reason might be that the severe radiation-induced injury caused by 10\u00a0Gy could obscure the additional effects of prior MPs exposure. Proteomic analysis implicated the \u2018PI3K-Akt signaling\u2019 pathway as a key mediator of this effect. Indeed, treatment with a PI3K inhibitor could attenuate the MPs-driven susceptibility of small intestine to radiation. These findings underscore the need to minimize MPs exposure in patients undergoing radiotherapy.<\/jats:p>","DOI":"10.1093\/jrr\/rraf046","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T14:43:36Z","timestamp":1753541016000},"page":"473-485","source":"Crossref","is-referenced-by-count":3,"title":["Prior exposure to microplastics heightened the susceptibility of small intestine to radiation-induced injury in C57BL\/6 mice"],"prefix":"10.1093","volume":"66","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Second Affiliated Hospital and Cancer Institute, Zhejiang University School of Medicine , No. 88 Jiefang Road, Shangcheng District, Hangzhou, 310009 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