{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:05:57Z","timestamp":1758773157126,"version":"3.44.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["23K14855"],"award-info":[{"award-number":["23K14855"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to analyze the clinical outcomes and prognostic factors of postoperative adjuvant radiotherapy (RT) for vulvar cancer based on a retrospective Japanese nationwide survey. Data were collected from 108 institutions for patients diagnosed with vulvar cancer between January 2001 and December 2010. Patients with histologically confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma who underwent curative surgery and adjuvant radiotherapy were included in this study. Survival outcomes were estimated using the Kaplan\u2013Meier method, and prognostic factors were analyzed via univariate and multivariate models. A total of 139 patients were included, with a median follow-up of 44 months (range: 3\u2013169). The 5-year overall survival (OS) rates (95% confidence interval [CI]) for stages I, II, III, and IV were 71.8% (50.8\u201392.8%), 61.3% (40.1\u201382.5%), 58.0% (45.8\u201370.2%), and 47.3% (27.5\u201367.1%), respectively. The corresponding 5-year cause-specific survival (CSS) rates (95% CI) for stages I, II, III, and IV were 71.8% (50.8\u201392.8%), 73.4% (53.0\u201393.8%), 62.2% (50.0\u201374.4%), and 47.3% (27.5\u201367.1%). Multivariate analysis identified age \u226570 years as an independent adverse prognostic factor for OS (hazard ratio [HR]: 1.848; 95% CI: 1.039\u20133.281; P = 0.042), while the presence of \u22652 inguinofemoral lymph node metastases was significantly associated with poorer CSS (HR: 2.179; 95% CI: 1.109\u20134.280; P = 0.030). Our analysis identified advanced age and a higher nodal burden as significant predictors of poorer survival outcomes in patients with vulvar cancer receiving postoperative adjuvant RT.<\/jats:p>","DOI":"10.1093\/jrr\/rraf050","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T11:14:33Z","timestamp":1752837273000},"page":"551-562","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes and prognostic factors of adjuvant radiotherapy for vulvar cancer: a Japanese Gynecologic Oncology Group nationwide survey study"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-6472","authenticated-orcid":false,"given":"Keisuke","family":"Tsuchida","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology , Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa 241-8515 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine , 3-39-22 Showa-machi, Maebashi, Gunma 371-8511 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-1922","authenticated-orcid":false,"given":"Noriyuki","family":"Okonogi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Juntendo University Graduate School of Medicine , 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuyo","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences , Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine , 2-174 Edobashi, Tsu, Mie 514-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine , 1-1-1 Minami Kogushi, Ube, Yamaguchi 755-8505 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-1845","authenticated-orcid":false,"given":"Munetaka","family":"Takekuma","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology , Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikou","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Jikei University School of Medicine , 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo 105-8461 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-3144","authenticated-orcid":false,"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine , 3-39-22 Showa-machi, Maebashi, Gunma 371-8511 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2526-630X","authenticated-orcid":false,"given":"Shin","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kurume University School of Medicine , 67 Asahi-machi, Kurume, Fukuoka 830-0011 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"2025092423163060500_ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2025092423163060500_ref2","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/ijc.34655","article-title":"Global 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