{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:24:26Z","timestamp":1785169466623,"version":"3.55.0"},"reference-count":179,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Skin is a tissue vulnerable to radiation exposure, which causes acute tissue reactions, including erythema, edema, desquamation, ulceration and late effects, such as skin cancers. As the effects of radiation exposure on the skin tissue are easily evaluated by visual examination, much information on radiation-induced skin reactions has been available from the clinical observation of people exposed to ionizing radiation, such as cancer patients receiving radiotherapy, although the mechanisms underlying skin reactions have not yet been fully understood. Recent advances in tissue biology at the molecular level have provided insights into the mechanisms of skin tissue reactions from the stem cell points of view. For example, our understanding of epidermal regeneration by epidermal stem cells as well as cells from the bulge in humans and the sebaceous gland in mouse, descriptions of the role of skin immune cells on inflammatory response and maintenance of genome integrity by epidermal stem cell competition, have greatly improved in the last decade with the identification of several key molecules. Thus, this review will provide an overview of the current status toward the comprehensive understanding of the mechanisms of adverse skin tissue reactions, with respect to mitigation of acute skin injuries as well as late carcinogenesis in response to ionizing radiation. In particular, the pleiotropic features of various types of cells consisting of skin tissue and their roles in securing skin functional homeostasis will be discussed.<\/jats:p>","DOI":"10.1093\/jrr\/rraf052","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T11:22:42Z","timestamp":1754306562000},"page":"437-450","source":"Crossref","is-referenced-by-count":11,"title":["Recent advances in understanding of radiation-induced skin tissue reactions with respect to acute tissue injury and late adverse effect"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-5445","authenticated-orcid":false,"given":"Keiko","family":"Iwashita","sequence":"first","affiliation":[{"name":"Division of Adult Nursing, Department of Specialized Nursing, Oita University of Nursing and Health Sciences , 2944-9 Megusuno, Oita 840-1201 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-9185","authenticated-orcid":false,"given":"Keiji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University , 1-12-4 Sakamoto, Nagasaki 852-8523 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Ojima","sequence":"additional","affiliation":[{"name":"Division of Adult Nursing, Department of Specialized Nursing, Oita University of Nursing and Health Sciences , 2944-9 Megusuno, Oita 840-1201 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"2025092423163890300_ref1","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1002\/jcp.30978","article-title":"Regulation of epidermal stratification and development by basal keratinocytes","volume":"238","author":"Yin","year":"2023","journal-title":"J Cell Physiol"},{"key":"2025092423163890300_ref2","doi-asserted-by":"crossref","first-page":"e00695","DOI":"10.1128\/IAI.00695-20","article-title":"Living in your skin: microbes, molecules, and mechanisms","volume":"89","author":"Swaney","year":"2021","journal-title":"Infect Immun"},{"key":"2025092423163890300_ref3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.it.2018.02.004","article-title":"Cutaneous barriers and skin immunity: differentiating a connected network","volume":"39","author":"Eyerich","year":"2018","journal-title":"Trend Immunol"},{"key":"2025092423163890300_ref4","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp Dermatol"},{"key":"2025092423163890300_ref5","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelop: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025092423163890300_ref6","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.1016\/j.ajic.2006.05.295","article-title":"Structure and function of the epidermal barrier","volume":"34","author":"Wickett","year":"2006","journal-title":"Am J Infect Control"},{"key":"2025092423163890300_ref7","doi-asserted-by":"publisher","first-page":"11676","DOI":"10.3390\/ijms222111676","article-title":"Five functional aspects of the epidermal barrier","volume":"22","author":"Lefevre-Utile","year":"2012","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref8","first-page":"3055","article-title":"Skin epidermis and barrier function","volume":"22","author":"Lim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref9","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.mrrev.2016.08.004","article-title":"Human epidermal stem cells: role in adverse skin reactions and carcinogenesis from radiation","volume":"770","author":"Martin","year":"2016","journal-title":"Mutat Res"},{"key":"2025092423163890300_ref10","article-title":"ICRP statement on tissue reactions\/early and late effects of radiation in normal tissues and organs \u2013 threshold doses for tissue reactions in a radiation protection context. ICRP publication 118","volume":"41","author":"ICRP","year":"2012","journal-title":"Ann ICRP"},{"key":"2025092423163890300_ref11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nrc2587","article-title":"Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype","volume":"9","author":"Barnett","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"2025092423163890300_ref12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2147\/CMAR.S188655","article-title":"Radiation-induced skin reactions: mechanism and treatment","volume":"11","author":"Wei","year":"2019","journal-title":"Cancer Manag Res"},{"key":"2025092423163890300_ref13","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1667\/RADE-20-00120.1","article-title":"Cutaneous radiation injuries: models, assessment and treatment","volume":"194","author":"Dicarlo","year":"2020","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref14","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/path.5389","article-title":"Radiation-induced tissue damage and response","volume":"250","author":"McBride","year":"2020","journal-title":"J Pathol"},{"key":"2025092423163890300_ref15","doi-asserted-by":"publisher","first-page":"23379","DOI":"10.18632\/aging.103932","article-title":"Radiation-induced skin injury: pathogenesis, treatment, and management","volume":"12","author":"Yang","year":"2020","journal-title":"Aging"},{"key":"2025092423163890300_ref16","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.3390\/ijms25063320","article-title":"Radiation dermatitis: radiation-induced effects on the structural and immunological barrier function of the epidermis","volume":"25","author":"Rube","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref17","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/jnci\/88.24.1848","article-title":"Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy","volume":"88","author":"Karagas","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"2025092423163890300_ref18","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1667\/RR13494.1","article-title":"Skin cancer incidence among atomic bomb survivors from 1958 to 1996","volume":"181","author":"Sugiyama","year":"2014","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref19","doi-asserted-by":"publisher","first-page":"i112","DOI":"10.1093\/jrr\/rrw005","article-title":"Epidermiological research on radiation-induced cancer in atomic bomb survivors","volume":"57","author":"Ozasa","year":"2016","journal-title":"J Radiat Res"},{"key":"2025092423163890300_ref20","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/1523-1747.ep12261462","article-title":"Cell proliferation in normal epidermis","volume":"82","author":"Weinstein","year":"1984","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref21","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1365-2133.1977.tb07152.x","article-title":"Epidermal 'turnover time': a new examination","volume":"96","author":"Bergstresser","year":"1977","journal-title":"Br J Dermatol"},{"key":"2025092423163890300_ref22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1749-6632.2009.04363.x","article-title":"Making an epidermis","volume":"1170","author":"Koster","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"2025092423163890300_ref23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/cosmetics4040047","article-title":"New method of measurement of epidermal turnover in humans","volume":"4","author":"Maeda","year":"2017","journal-title":"Cosmetics"},{"key":"2025092423163890300_ref24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/1523-1747.ep12532758","article-title":"Perspectives and problems in cutaneous gerontology","volume":"73","author":"Kligman","year":"1979","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/1523-1747.ep12532763","article-title":"Structural alterations in exposed and unexposed aged skin","volume":"73","author":"Lavker","year":"1979","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/path.2098","article-title":"Skin ageing and its treatment","volume":"211","author":"Baumann","year":"2007","journal-title":"J Pathol"},{"key":"2025092423163890300_ref27","doi-asserted-by":"publisher","first-page":"12489","DOI":"10.3390\/ijms222212489","article-title":"Structural and functional changes and possible molecular mechanisms in aged skin","volume":"22","author":"Lee","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref28","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.2147\/CCID.S408765","article-title":"Skin ageing: a progressive, multifactorial condition demanding an integrated, multilayer-targeted remedy","volume":"16","author":"Liang","year":"2023","journal-title":"Clin Comset Investig Dermatol"},{"key":"2025092423163890300_ref29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000534756","article-title":"Cellular senescence in human skin aging: leveraging senotherapeutics","volume":"70","author":"Wyes","year":"2024","journal-title":"Gerontol"},{"key":"2025092423163890300_ref30","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1432-0436.2004.07208005.x","article-title":"Location and phenotype of human adult keratinocyte stem cells of the skin","volume":"72","author":"Webb","year":"2004","journal-title":"Different Res Biol Divers"},{"key":"2025092423163890300_ref31","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.radonc.2007.05.007","article-title":"Sensing radiosensitivity of human epidermal stem cells","volume":"83","author":"Rachidi","year":"2007","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"2025092423163890300_ref32","doi-asserted-by":"publisher","first-page":"11412","DOI":"10.1073\/pnas.2034935100","article-title":"Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells","volume":"100","author":"Schneider","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025092423163890300_ref33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2184.1974.tb00401.x","article-title":"The epidermal proliferative unit: the possible role of the central basal cell","volume":"7","author":"Potten","year":"1974","journal-title":"Cell Tissue Kinet"},{"key":"2025092423163890300_ref34","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1087-0024.2004.09305.x","article-title":"Keratinocyte stem cells, label-retaining cells and possible genome protection mechanisms","volume":"9","author":"Potten","year":"2004","journal-title":"J Investig Dermatol Symp Proc"},{"key":"2025092423163890300_ref35","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/ncb3359","article-title":"Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin","volume":"18","author":"Sada","year":"2016","journal-title":"Nat Cell Biol"},{"key":"2025092423163890300_ref36","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.stem.2016.06.010","article-title":"Fate by chance, not by choice: epidermal stem cells go live","volume":"19","author":"Gonzalez-Celeiro","year":"2016","journal-title":"Cell Stem Cell"},{"key":"2025092423163890300_ref37","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1126\/science.aaf7012","article-title":"Spatiotemporal coordination of stem cell commitment during epidermal homeostasis","volume":"352","author":"Rompolas","year":"2016","journal-title":"Science"},{"key":"2025092423163890300_ref38","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1038\/s41467-020-15258-0","article-title":"A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice","volume":"11","author":"Piedrafita","year":"2020","journal-title":"Nat Commun"},{"key":"2025092423163890300_ref39","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1038\/s41467-020-18075-7","article-title":"Single cell transcriptomics of human epidermis identifies basal stem cell transition states","volume":"11","author":"Wang","year":"2020","journal-title":"Nat Commun"},{"key":"2025092423163890300_ref40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s12276-023-01151-5","article-title":"Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration","volume":"56","author":"Lee","year":"2014","journal-title":"Exp Mol Med"},{"key":"2025092423163890300_ref41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/JID.2015.354","article-title":"A guide to studying human hair follicle cycling in vivo","volume":"136","author":"Oh","year":"2016","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref42","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.3389\/fcell.2022.899095","article-title":"Morphogenesis, growth cycle and molecular regulation of hair follicles","volume":"10","author":"Lin","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2025092423163890300_ref43","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/jcm12030893","article-title":"Integrative and mechanistic approach to the hair growth cycle and hair loss","volume":"12","author":"Natarelli","year":"2023","journal-title":"J Clin Med"},{"key":"2025092423163890300_ref44","doi-asserted-by":"publisher","first-page":"a013631","DOI":"10.1101\/cshperspect.a013631","article-title":"Markers of epidermal stem cell subpopulations in adult mammalian skin","volume":"4","author":"Kretzschmar","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025092423163890300_ref45","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ceb.2020.09.004","article-title":"Advances in resolving the heterogeneity and dynamics of keratinocyte differentiation","volume":"67","author":"Rice","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"2025092423163890300_ref46","doi-asserted-by":"publisher","first-page":"1379490","DOI":"10.3389\/fimmu.2024.1379490","article-title":"The role of dermal fibroblasts in autoimmune skin diseases","volume":"15","author":"Shi","year":"2014","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref47","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/cells8060607","article-title":"Regeneration of dermis: scaring and cells involved","volume":"8","author":"Rippa","year":"2019","journal-title":"Cells"},{"key":"2025092423163890300_ref48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1087-0024.2000.00010.x","article-title":"The cutaneous microcirculation","volume":"5","author":"Braverman","year":"2000","journal-title":"J Invest Dermatol Symp Proc"},{"key":"2025092423163890300_ref49","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.reprotox.2015.10.001","article-title":"What happens in the skin? Integrative skin permeation kinetics into studies of developmental and reproductive toxicity following topical exposure","volume":"58","author":"Dancik","year":"2015","journal-title":"Reproduct Toxicol"},{"key":"2025092423163890300_ref50","doi-asserted-by":"crossref","first-page":"07TR01","DOI":"10.1088\/1361-6560\/ab03f1","article-title":"Microvasculature imaging of the skin","volume":"64","author":"Deegan","year":"2021","journal-title":"Phys Med Biol"},{"key":"2025092423163890300_ref51","doi-asserted-by":"publisher","first-page":"a015271","DOI":"10.1101\/cshperspect.a015271","article-title":"Adipocytes in skin health and disease","volume":"4","author":"Rivera-Gonzalez","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025092423163890300_ref52","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.18632\/aging.100999","article-title":"Skin aging: are adipocytes the next target?","volume":"8","author":"Kruglikov","year":"2016","journal-title":"Aging"},{"key":"2025092423163890300_ref53","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nrendo.2017.162","article-title":"Emerging nonmetabolic functions of the skin fat","volume":"14","author":"Guerrero-Jurarez","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2025092423163890300_ref54","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.tem.2018.11.004","article-title":"The role of immature and mature adipocytes in hair cycling","volume":"30","author":"Kruglikov","year":"2019","journal-title":"Trend Endocrinol Metab"},{"key":"2025092423163890300_ref55","doi-asserted-by":"publisher","first-page":"9006","DOI":"10.3390\/ijms22169006","article-title":"Furnishing wound repair by the subcutaneous fascia","volume":"22","author":"Jiang","year":"2012","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref56","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/s41586-019-1794-y","article-title":"Patch repair of deep wound by mobilized fascia","volume":"576","author":"Corres-Gallegos","year":"2019","journal-title":"Nature"},{"key":"2025092423163890300_ref57","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.3390\/ijms24032936","article-title":"Fascia layer - a novel target for the application of biomaterials in skin wound healing","volume":"24","author":"Ye","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref58","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/joa.12840","article-title":"The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research field","volume":"233","author":"Naldaiz-Gastesi","year":"2018","journal-title":"J Anat"},{"key":"2025092423163890300_ref59","first-page":"2525","article-title":"Tight junctions\/adherens junctions: basic structure and function","volume":"127","author":"Niessen","year":"2007","journal-title":"Dermatol"},{"key":"2025092423163890300_ref60","first-page":"11","article-title":"Antimicrobial peptides in human skin disease","volume":"18","author":"Yamasaki","year":"2008","journal-title":"Eur J Dermatol"},{"key":"2025092423163890300_ref61","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"2025092423163890300_ref62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/5954034","article-title":"Lipids and the permeability and antimicrobial barriers of the skin","volume":"2018","author":"Wertz","year":"2018","journal-title":"J Lipids"},{"key":"2025092423163890300_ref63","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12934-022-01901-6","article-title":"Advances in the skin microbiota and its roles in cutaneous diseases","volume":"21","author":"Yang","year":"2022","journal-title":"Microb Cell Factories"},{"key":"2025092423163890300_ref64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/mlf2.12064","article-title":"Human skin bacterial microbiota homeostasis: a delicate balance between health and disease","volume":"2","author":"Zhu","year":"2023","journal-title":"mLife"},{"key":"2025092423163890300_ref65","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1396-0296.2004.04S1005.x","article-title":"Moisturization and skin barrier function","volume":"17","author":"Rawlings","year":"2004","journal-title":"Dermatologic Ther"},{"key":"2025092423163890300_ref66","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1111\/j.1365-2133.2009.09342.x","article-title":"Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods","volume":"161","author":"Kezic","year":"2009","journal-title":"Br J Dermatol"},{"key":"2025092423163890300_ref67","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/ics.12832","article-title":"Moisturizing at a molecular level - the basis of corneocare","volume":"45","author":"Voegeli","year":"2023","journal-title":"Int J Cosmet Sci"},{"key":"2025092423163890300_ref68","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The immunological anatomy of the skin","volume":"19","author":"Kabashima","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2025092423163890300_ref69","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"2025092423163890300_ref70","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nri3646","article-title":"Mechanisms regulating skin immunity and inflammation","volume":"14","author":"Pasparakis","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"2025092423163890300_ref71","doi-asserted-by":"publisher","first-page":"e142067","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin","volume":"5","author":"Jiang","year":"2020","journal-title":"JCI Insight"},{"key":"2025092423163890300_ref72","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nri2455","article-title":"Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells","volume":"8","author":"Merad","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2025092423163890300_ref73","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.it.2017.06.008","article-title":"Langerhans cells - the macrophage in dendritic cell clothing","volume":"38","author":"Doebel","year":"2017","journal-title":"Trend Immunol"},{"key":"2025092423163890300_ref74","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/ni.3815","article-title":"Ontogeny and function of murine epidermal Langerhans cells","volume":"18","author":"Kaplan","year":"2017","journal-title":"Nat Immunol"},{"key":"2025092423163890300_ref75","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fimmu.2018.00093","article-title":"Langerhans cells: sensing the environment in health and disease","volume":"9","author":"Deckers","year":"2018","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref76","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.3389\/fimmu.2017.01941","article-title":"Redefining of the role of Langerhans cells as immune regulators within the skin","volume":"8","author":"West","year":"2018","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref77","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.3389\/fimmu.2020.01656","article-title":"Get in touch with dendritic epithelial T cells!","volume":"11","author":"Thelen","year":"2020","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref78","doi-asserted-by":"publisher","first-page":"e2219932120","DOI":"10.1073\/pnas.2219932120","article-title":"Cross-presenting Langerhans cells are required for the early reactivation of resident CD8+ memory T cells in the epidermis","volume":"120","author":"Kamenjarin","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025092423163890300_ref79","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.it.2014.12.006","article-title":"Revisiting the role of B cells in skin immune surveillance","volume":"36","author":"Egbuniwe","year":"2015","journal-title":"Trend Immunol"},{"key":"2025092423163890300_ref80","doi-asserted-by":"publisher","first-page":"440","DOI":"10.21037\/atm-20-5185","article-title":"Human cutaneous B cells: what do we know?","volume":"9","author":"Lerman","year":"2021","journal-title":"Ann Transl Med"},{"key":"2025092423163890300_ref81","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/ni.2680","article-title":"The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells","volume":"14","author":"Heath","year":"2013","journal-title":"Nat Immunol"},{"key":"2025092423163890300_ref82","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41556-021-00680-3","article-title":"Tracking skin and immune cell interactions","volume":"23","author":"Lim","year":"2021","journal-title":"Nat Cell Biol"},{"key":"2025092423163890300_ref83","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: difference between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"key":"2025092423163890300_ref84","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1007\/s00018-011-0702-x","article-title":"Functions of skin-resident gdT cells","volume":"68","author":"MacLeod","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2025092423163890300_ref85","doi-asserted-by":"publisher","first-page":"19739","DOI":"10.1073\/pnas.1208927109","article-title":"Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen","volume":"109","author":"Ariotti","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025092423163890300_ref86","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nri.2017.101","article-title":"gdT cells in homeostasis and host defence of epithelial barrier tissues","volume":"17","author":"Nielsen","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2025092423163890300_ref87","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/imcb.12026","article-title":"The lymphoid cell network in the skin","volume":"96","author":"Tikoo","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"2025092423163890300_ref88","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.it.2019.12.004","article-title":"Skin-resident lymphoid cells - cutaneous innate guardians and regulators","volume":"41","author":"Kobayashi","year":"2020","journal-title":"Trend Immunol"},{"key":"2025092423163890300_ref89","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3389\/fimmu.2020.00874","article-title":"Dendritic epidermal T cells in allergic contact dermatitis","volume":"11","author":"Mraz","year":"2020","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref90","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.jid.2019.09.014","article-title":"Migration and function of memory CD8+ T cells in skin","volume":"140","author":"Hirai","year":"2020","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref91","doi-asserted-by":"publisher","first-page":"758522","DOI":"10.3389\/fimmu.2021.758522","article-title":"Innate lymphoid cells in skin homeostasis and malignancy","volume":"12","author":"Wagner","year":"2021","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref92","doi-asserted-by":"publisher","first-page":"896228","DOI":"10.3389\/fimmu.2022.896228","article-title":"All about (NK cell-mediated) death in two acts and an unexpected encore: initiation, execution and activation of adaptive immunity","volume":"13","author":"Ramirez-Labrada","year":"2022","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref93","doi-asserted-by":"publisher","first-page":"981","DOI":"10.4049\/jimmunol.2200637","article-title":"Role of NK cells in skin wound healing of mice","volume":"210","author":"Cavalcante-Silva","year":"2023","journal-title":"J Immunol"},{"key":"2025092423163890300_ref94","doi-asserted-by":"publisher","first-page":"i30","DOI":"10.1093\/jrr\/rraa086","article-title":"Recent advances in radiobiology with respect to pleiotropic aspects of tissue reaction","volume":"62","author":"Suzuki","year":"2021","journal-title":"J Radiat Res"},{"key":"2025092423163890300_ref95","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1038\/sj.cdd.4401722","article-title":"Death penalty for keratinocytes: apoptosis versus cornification","volume":"12","author":"Lippens","year":"2005","journal-title":"Cell Death Differ"},{"key":"2025092423163890300_ref96","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3857\/roj.2014.32.3.103","article-title":"Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials","volume":"32","author":"Kim","year":"2014","journal-title":"Radiat Oncol J"},{"key":"2025092423163890300_ref97","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jdermsci.2023.01.001","article-title":"Integrative multi-omic analysis of radiation-induced skin injury reveals the alteration of fatty acid metabolism in early response of ionizing radiation","volume":"108","author":"Tu","year":"2022","journal-title":"J Dermatol Sci"},{"key":"2025092423163890300_ref98","doi-asserted-by":"publisher","first-page":"957","DOI":"10.3109\/09553002.2015.1101647","article-title":"The effects of gamma rays on the regeneration of hair follicles are carried over to late hair cycles","volume":"91","author":"Sugaya","year":"2015","journal-title":"Int J Radiat Biol"},{"key":"2025092423163890300_ref99","doi-asserted-by":"publisher","first-page":"111283","DOI":"10.1016\/j.jtbi.2022.111283","article-title":"Modeling of ionizing radiation induced hair follicle regenerative dynamics","volume":"555","author":"Duran","year":"2022","journal-title":"J Theoret Biol"},{"key":"2025092423163890300_ref100","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/sj.jid.5700007","article-title":"Apoptosis in the hair follicle","volume":"126","author":"Botchkareva","year":"2006","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref101","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jid.2016.10.017","article-title":"Holocrine secretion of sebum is a unique DNase2-dependent mode of programmed cell death","volume":"137","author":"Fischer","year":"2017","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref102","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/ijms19010185","article-title":"Impaired skin barrier due to sebaceous gland atrophy in the later stage of radiation-induced skin injury: application of non-invasive diagnostic methods","volume":"19","author":"Jang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref103","doi-asserted-by":"publisher","first-page":"113121","DOI":"10.1016\/j.celrep.2023.113121","article-title":"Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury","volume":"42","author":"Veniaminova","year":"2023","journal-title":"Cell Rep"},{"key":"2025092423163890300_ref104","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/biom14010020","article-title":"Controlling hair loss by regulating apoptosis in hair follicles: a comprehensive overview","volume":"14","author":"Wang","year":"2023","journal-title":"Biomolecules"},{"key":"2025092423163890300_ref179","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/jid.2011.411","article-title":"Ionizing radiation: the good, the bad, and the ugly","volume":"132","author":"Ryan","year":"2012","journal-title":"J Clinical Dermatol"},{"key":"2025092423163890300_ref105","doi-asserted-by":"publisher","first-page":"A1","DOI":"10.1016\/0146-6453(91)90019-D","article-title":"The biological basis for dose limitation in the skin. A report of a task group committee 1 of the international commission on radiological protection","volume":"22","author":"ICRP","year":"1991","journal-title":"Ann ICRP"},{"key":"2025092423163890300_ref106","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrm2636","article-title":"Epidermal homeostasis: a balancing act of stem cells in the skin","volume":"10","author":"Blanpain","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025092423163890300_ref107","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pena","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025092423163890300_ref108","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.3390\/ijms24043749","article-title":"Burns: classification, pathophysiology, and treatments: a review","volume":"24","author":"Zwierello","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref109","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1055\/s-0039-1699465","article-title":"Radiation injury","volume":"43","author":"Bhattacharya","year":"2010","journal-title":"Indian J Plast Surg Supplement"},{"key":"2025092423163890300_ref110","first-page":"1","volume-title":"Department of the Army Technical Manual","author":"DOA","year":":    , 1969"},{"key":"2025092423163890300_ref111","doi-asserted-by":"publisher","first-page":"1297637","DOI":"10.3389\/fphys.2023.1297637","article-title":"The role of cellular senescence in skin aging and age-related skin pathologies","volume":"14","author":"Chin","year":"2023","journal-title":"Front Physiol"},{"key":"2025092423163890300_ref112","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.ijrobp.2023.09.022","article-title":"Immunomodulatory effects of histone variant H2A.J in ionizing radiation dermatitis","volume":"118","author":"Tewary","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025092423163890300_ref113","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41418-024-01297-3","article-title":"Cell death as an architect of adult skin stem cell niches","volume":"31","author":"Lecomte","year":"2024","journal-title":"Cell Death Differ"},{"key":"2025092423163890300_ref114","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1158\/0008-5472.CAN-17-0667","article-title":"Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy and radiation therapy","volume":"77","author":"Huang","year":"2017","journal-title":"Cancer Res"},{"key":"2025092423163890300_ref115","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/brv.12648","article-title":"The biology of human hair greying","volume":"96","author":"O'Sullivan","year":"2021","journal-title":"Biol Rev Camb Philos Soc"},{"key":"2025092423163890300_ref116","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1038\/jid.2013.155","article-title":"Keratinocyte stem cells but not melanocyte stem cells are the primary target for radiation-induced hair greying","volume":"133","author":"Aoki","year":"2013","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref117","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40164-025-00596-w","article-title":"Molecular profiling of skin cells identifies distinct cellular signatures in radiation-induced skin injury across various stages in the murine dataset","volume":"14","author":"Yu","year":"2025","journal-title":"Exp Hematol Oncol"},{"key":"2025092423163890300_ref118","doi-asserted-by":"publisher","first-page":"5809","DOI":"10.7150\/thno.100417","article-title":"Single-cell RNA-seq analysis of molecular changes during radiation-induced skin injury: the involvement of Nur77","volume":"14","author":"Yan","year":"2024","journal-title":"Theranostics"},{"key":"2025092423163890300_ref119","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Ann Rev Pathol Mech Dis"},{"key":"2025092423163890300_ref120","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Munoz-Espin","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025092423163890300_ref121","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/cas.13184","article-title":"Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases","volume":"108","author":"Watanabe","year":"2017","journal-title":"Cancer Sci"},{"key":"2025092423163890300_ref122","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41568-019-0156-2","article-title":"Unmasking senescence: context-dependent effects of SASP in cancer","volume":"19","author":"Faget","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"2025092423163890300_ref123","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/s43587-023-00446-6","article-title":"Spatial mapping of cellular senescence: emerging challenges and opportunities","volume":"3","author":"Gurkar","year":"2023","journal-title":"Nat Aging"},{"key":"2025092423163890300_ref124","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/jid.2011.262","article-title":"Human keratinocytes\u2019 response to injury upregulates CCL20 and other genes linking innate and adaptive immunity","volume":"132","author":"Kennedy-Crispin","year":"2012","journal-title":"J Invest Dermatol"},{"key":"2025092423163890300_ref125","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1667\/RR007CC.1","article-title":"Radiation-induced dermatitis is mediated by IL17-expressing gd T cells","volume":"187","author":"Liao","year":"2017","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref126","first-page":"e12846","article-title":"The CCL20 and CCR6 axis in psoriasis","volume":"91","author":"Furue","year":"2019","journal-title":"Immunol"},{"key":"2025092423163890300_ref127","doi-asserted-by":"publisher","first-page":"594735","DOI":"10.3389\/fimmu.2020.594735","article-title":"The IL-23\/IL-17 pathway in inflammatory skin diseases: from bench to bedside","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref128","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41419-020-2495-z","article-title":"Keratinocyte transglutaminase 2 promotes CCR6+ \u03b3\u03b4T-cell recruitment by upregulating CCL20 in psoriatic inflammation","volume":"11","author":"Shin","year":"2020","journal-title":"Cell Death Disease"},{"key":"2025092423163890300_ref129","doi-asserted-by":"publisher","first-page":"652846","DOI":"10.3389\/fimmu.2021.652846","article-title":"IL-1 family antagonists in mouse and human skin inflammation","volume":"12","author":"Martin","year":"2021","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref130","doi-asserted-by":"publisher","first-page":"e15653","DOI":"10.15252\/emmm.202115653","article-title":"Single-cell transcriptomics reveals a senescence-associated IL-6\/CCR6 axis driving radiodermatitis","volume":"14","author":"Paldor","year":"2022","journal-title":"EMBO Mol Med"},{"key":"2025092423163890300_ref131","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12967-024-04972-8","article-title":"Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization","volume":"22","author":"Chen","year":"2024","journal-title":"J Transl Med"},{"key":"2025092423163890300_ref132","doi-asserted-by":"publisher","first-page":"1338922","DOI":"10.3389\/fimmu.2024.1338922","article-title":"Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref133","doi-asserted-by":"publisher","first-page":"328","DOI":"10.18632\/aging.100897","article-title":"NKG2D ligands mediate immunosurveillance of senescent cells","volume":"8","author":"Sagiv","year":"2016","journal-title":"Aging"},{"key":"2025092423163890300_ref134","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3389\/fimmu.2018.00441","article-title":"NKG2D: a master regulator of immune cell responsiveness","volume":"9","author":"Wensveen","year":"2018","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref135","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1002\/JLB.MR0718-299R","article-title":"Senescence cells: living or dying is a matter of NK cells","volume":"105","author":"Antonangeli","year":"2019","journal-title":"J Leukoc Biol"},{"key":"2025092423163890300_ref136","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12985-024-02287-0","article-title":"Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications","volume":"21","author":"Letafati","year":"2024","journal-title":"Virol J"},{"key":"2025092423163890300_ref137","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.immuni.2023.11.018","article-title":"Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection","volume":"57","author":"Torcellan","year":"2024","journal-title":"Immunity"},{"key":"2025092423163890300_ref138","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1269\/jrr.31.246","article-title":"The effect of ionizing radiation on epidermal Langerhans cells","volume":"31","author":"Kawase","year":"1990","journal-title":"J Radiat Res"},{"key":"2025092423163890300_ref139","doi-asserted-by":"publisher","first-page":"662594","DOI":"10.3389\/fimmu.2021.662594","article-title":"Ionizing radiation curtails immunosuppressive effects from cancer-associated fibroblasts on dendritic cells","volume":"12","author":"Berzaghi","year":"2021","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/cancers15010270","article-title":"Macrophage resistance to ionizing radiation exposure is accompanied by decreased cathepsin D and increased transferrin receptor an expression","volume":"15","author":"Pinto","year":"2023","journal-title":"Cancers"},{"key":"2025092423163890300_ref141","doi-asserted-by":"publisher","first-page":"875076","DOI":"10.3389\/fimmu.2022.875076","article-title":"Skin \u03b3\u03b4T cells and their function in wound healing","volume":"13","author":"Hu","year":"2022","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref142","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1073\/pnas.0437899100","article-title":"Antigen presentation by keratinocytes directs autoimmune skin disease","volume":"100","author":"Fan","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025092423163890300_ref143","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ebiom.2017.12.022","article-title":"Langerhans cells prevent autoimmune via expansion of keratinocyte antigen-specific regulatory T cells","volume":"27","author":"Kitashima","year":"2018","journal-title":"EBioMed"},{"key":"2025092423163890300_ref144","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fimmu.2014.00332","article-title":"Tissue-resident T cells: dynamic players in skin immunity","volume":"5","author":"Mueller","year":"2014","journal-title":"Front Immunol"},{"key":"2025092423163890300_ref145","doi-asserted-by":"publisher","first-page":"e100800","DOI":"10.1371\/journal.pone.0100800","article-title":"Ionizing radiation selectively reduces skin regulatory T cells and alters immune function","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"2025092423163890300_ref146","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s41586-019-1085-7","article-title":"Stem cell competition orchestrates skin homeostasis and ageing","volume":"568","author":"Liu","year":"2019","journal-title":"Nature"},{"key":"2025092423163890300_ref147","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1016\/j.devcel.2021.11.018","article-title":"Dynamic stem cells selection safeguards the genomic integrity of the epidermis","volume":"56","author":"Kato","year":"2021","journal-title":"Dev Cell"},{"key":"2025092423163890300_ref148","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12885-019-5334-9","article-title":"Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial","volume":"19","author":"Ogita","year":"2019","journal-title":"BMC Cancer"},{"key":"2025092423163890300_ref149","doi-asserted-by":"crossref","first-page":"a015222","DOI":"10.1101\/cshperspect.a015222","article-title":"Sweat gland progenitors in development, homeostasis, and wound repair","volume":"4","author":"Lu","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025092423163890300_ref150","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12967-020-02248-5","article-title":"Regeneration of skin appendages and nerves: current status and further challenges","volume":"18","author":"Weng","year":"2020","journal-title":"J Transl Med"},{"key":"2025092423163890300_ref151","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1667\/RR4284.S1","article-title":"Ionizing radiation exposure and basal cell carcinoma pathogenesis","volume":"185","author":"Li","year":"2016","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref152","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1093\/jnci\/djs298","article-title":"Radiation-related risk of basal cell carcinoma: A report from the childhood cancer survivors study","volume":"104","author":"Watt","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"2025092423163890300_ref153","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1136\/oemed-2015-102880","article-title":"Occupational ionising radiation and risk of basal cell carcinoma in US radiogenic technologists (1983-2005)","volume":"72","author":"Lee","year":"2015","journal-title":"Occup Environ Med"},{"key":"2025092423163890300_ref154","doi-asserted-by":"publisher","first-page":"e0205060","DOI":"10.1371\/journal.pone.0205060","article-title":"Risk of malignant skin neoplasm in a cohort of workers occupationally exposed to ionizing radiation at low dose rates","volume":"13","author":"Azizova","year":"2018","journal-title":"PLoS One"},{"key":"2025092423163890300_ref155","article-title":"Stem cell biology with respect to carcinogenesis aspects of radiological protection. ICRP publication 131","volume":"44","author":"ICRP","year":"2015","journal-title":"Ann ICRP"},{"key":"2025092423163890300_ref156","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2307\/3577298","article-title":"One hundred percent tumor induction in mouse skin after repeated b irradiation in a limited dose range","volume":"115","author":"Ootsuyama","year":"1988","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref157","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2307\/3577987","article-title":"Threshold-like dose of local b irradiation repeated throughout the life span of mice for induction of skin and bone tumors","volume":"125","author":"Ootsuyama","year":"1991","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref158","doi-asserted-by":"publisher","first-page":"244","DOI":"10.2307\/3578465","article-title":"Zero tumor incidence in mice after repeated lifetime exposures to 0.5 Gy of beta radiation","volume":"134","author":"Ootsuyama","year":"1993","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref159","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrc3079","article-title":"The Hedgehog\u2019s tale: developing strategies for targeting cancer","volume":"11","author":"Ng","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"2025092423163890300_ref160","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3389\/fgene.2019.00556","article-title":"Non-canonical hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened","volume":"10","author":"Pietrobono","year":"2019","journal-title":"Front Genet"},{"key":"2025092423163890300_ref161","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.3390\/ijms18112485","article-title":"Understanding the molecular genetics of basal cell carcinoma","volume":"18","author":"Pellegrini","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025092423163890300_ref162","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/09553002.2024.2442690","article-title":"An examination of the dose rate effect in mice assuming that the carcinogenic effect of radiation is life shortening resulting from a tissue reaction","volume":"101","author":"Nakamura","year":"2025","journal-title":"Int J Radiat Biol"},{"key":"2025092423163890300_ref163","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.2307\/3578892","article-title":"Cancer incidence in atomic bomb survivors. Part II solid tumors, 1958-1987","volume":"137","author":"Thompson","year":"1994","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref164","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2307\/3578117","article-title":"Radiation-induced skin carcinomas of the head and neck","volume":"125","author":"Ron","year":"1991","journal-title":"Radiat Res"},{"key":"2025092423163890300_ref165","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1188\/20.ONF.654-670","article-title":"ONS guide lines for cancer treatment-related radiodermatitis","volume":"47","author":"Gosselin","year":"2020","journal-title":"Oncol Nurs Forum"},{"key":"2025092423163890300_ref166","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1007\/s00520-022-06829-6","article-title":"Comparison of clinical guidelines on radiation dermatitis: a narrative review","volume":"30","author":"Finkelstein","year":"2022","journal-title":"Support Care Cancer"},{"key":"2025092423163890300_ref167","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1007\/s00520-023-08011-y","article-title":"Shedding light on the management of acute radiation dermatitis: insight from the MASCC oncodermatology study group","volume":"31","author":"Bonomo","year":"2023","journal-title":"Support Care Cancer"},{"key":"2025092423163890300_ref168","doi-asserted-by":"publisher","first-page":"101886","DOI":"10.1016\/j.eclinm.2023.101886","article-title":"MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis. Part 1: systematic review","volume":"58","author":"Behroozian","year":"2023","journal-title":"eClinicalMed"},{"key":"2025092423163890300_ref169","doi-asserted-by":"publisher","first-page":"e172","DOI":"10.1016\/S1470-2045(23)00067-0","article-title":"Multinational association of supportive care in cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations","volume":"24","author":"Behroozian","year":"2023","journal-title":"Lancet Oncol"},{"key":"2025092423163890300_ref170","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00520-023-07707-5","article-title":"Systematic review and meta-analysis on interventions for radiation dermatitis prevention and management: an overview of the method","volume":"31","author":"Behroozian","year":"2023","journal-title":"Support Care Cancer"},{"key":"2025092423163890300_ref171","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00520-023-07673-y","article-title":"Photobiomodulation therapy for the prevention of acute radiation dermatitis: a systematic review and meta-analysis","volume":"31","author":"Gobbo","year":"2023","journal-title":"Support Care Cancer"},{"key":"2025092423163890300_ref172","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.radonc.2014.01.005","article-title":"Prophylactic use of Mepitel film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients","volume":"110","author":"Herst","year":"2014","journal-title":"Radiother Oncol"},{"key":"2025092423163890300_ref173","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1200\/JCO.22.01873","article-title":"Mepitel film for the prevention of acute radiation dermatitis in breast cancer: a randomized multicenter open-label phase III trial","volume":"41","author":"Behroozian","year":"2022","journal-title":"J Clin Oncol"},{"key":"2025092423163890300_ref174","doi-asserted-by":"publisher","first-page":"20170298","DOI":"10.1259\/bjr.20170298","article-title":"The effect of Mepitel film on acute radiation-induced skin reactions in head and neck cancer patients: a feasibility study","volume":"91","author":"Wooding","year":"2018","journal-title":"Br J Radiol"},{"key":"2025092423163890300_ref175","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/jmrs.397","article-title":"Mepitel film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: a randomised intra-patient controlled clinical trial","volume":"67","author":"Yan","year":"2020","journal-title":"J Med Radiat Sci"},{"key":"2025092423163890300_ref176","first-page":"219","article-title":"Barrier films and dressings for the prevention of acute radiation dermatitis: a systemic review and meta-analysis","volume":"31","author":"Robijns","year":"2023","journal-title":"Support Care Cancer"},{"key":"2025092423163890300_ref177","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s00520-023-07820-5","article-title":"Topical corticosteroids for the prevention of severe radiation dermatitis: a systematic review and meta-analysis","volume":"31","author":"Tam","year":"2023","journal-title":"Support Care Cancer"},{"key":"2025092423163890300_ref178","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0167-8140(00)00322-4","article-title":"The impact of skin washing with water and soap during breast irradiation: a randomized study","volume":"58","author":"Roy","year":"2001","journal-title":"Radiother Oncol"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jrr\/article-pdf\/66\/5\/437\/64107042\/rraf052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jrr\/article-pdf\/66\/5\/437\/64107042\/rraf052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:17:02Z","timestamp":1758770222000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/66\/5\/437\/8239647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":179,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,8,22]]},"published-print":{"date-parts":[[2025,9,23]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rraf052","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,8,22]]}}}