{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:21:40Z","timestamp":1784697700586,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Helical tomotherapy-based total body irradiation (TBI) traditionally employs megavoltage computed tomography (MVCT) for image-guided setup; however, its 390\u00a0mm field of view (FOV) and long acquisition times constrain workflow efficiency and whole-body alignment. This study evaluated whether a newly implemented whole-body fan-beam kilovoltage CT (kVCT; 500\u00a0mm FOV) can streamline this process. In a retrospective study involving 14 patients treated with a Radixact X9 system (September 2021\u2013September 2023), we timed the patient setup, imaging, registration, re-setup, and beam delivery for each upper-body (UB) and lower-body (LB) segment. Residual setup errors were measured along the lateral, longitudinal, and vertical axes. The kVCT shortened the initial setup cycle (setup + imaging + registration) from 25.4\u2009\u00b1\u20094.6 to 15.9\u2009\u00b1\u20093.3\u00a0min for UB and from 14.5\u2009\u00b1\u20093.8 to 9.4\u2009\u00b1\u20092.4\u00a0min for LB (P\u00a0&amp;lt;\u20090.001 for both). The total fraction time, including delivery time, decreased from 71.8\u2009\u00b1\u20097.5 to 56.7\u2009\u00b1\u20095.3\u00a0min. When residual errors exceeded 5\u00a0mm, the additional time required for a second cycle was nearly halved with kVCT (7.3 vs. 14.3\u00a0min for UB; 4.8 vs. 8.2\u00a0min for LB). The kVCT maintained mean absolute residual errors below 2\u00a0mm in all axes, and every 95th-percentile value remained within the 5\u00a0mm tolerance recommended for tomotherapy-based TBI. These time savings are expected to reduce intrafraction motion and staff workload. Overall, whole-body kVCT enables faster, comprehensive image guidance while preserving accuracy, thereby streamlining tomotherapy-based TBI and reducing the burden on patients and clinical staff.<\/jats:p>","DOI":"10.1093\/jrr\/rraf062","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T18:27:46Z","timestamp":1759861666000},"page":"727-736","source":"Crossref","is-referenced-by-count":1,"title":["Comparative analysis of kVCT- and MVCT-guided helical tomotherapy for total body irradiation: evaluation of process times and residual setup errors"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-0704","authenticated-orcid":false,"given":"Yuta","family":"Omi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Yada","sequence":"additional","affiliation":[{"name":"Department of Regional Medical Management Studies, Hamamatsu University School of Medicine , Handayama 1-20-1, Chuo-ku, Hamamatsu City, Shizuoka 431-3192 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shishido","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-881X","authenticated-orcid":false,"given":"Katsumasa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hamamatsu University School of Medicine , Handayama 1-20-1, Chuo-ku, Hamamatsu City, Shizuoka 431-3192 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Anjo Kosei Hospital , 28 Higashi-Hirokute, Anjo-cho, Anjo City, Aichi 446-8602 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"2025112604222448700_ref1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ijrobp.2018.04.071","article-title":"Total body irradiation: guidelines from the international lymphoma radiation oncology group (ILROG)","volume":"101","author":"Wong","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025112604222448700_ref2","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3390\/curroncol28010089","article-title":"Total body irradiation for hematopoietic stem cell transplantation: what can we agree on?","volume":"28","author":"Sabloff","year":"2021","journal-title":"Curr Oncol"},{"key":"2025112604222448700_ref3","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/bmt.2010.237","article-title":"Clinical feasibility of TBI with helical tomotherapy","volume":"46","author":"Pe\u00f1agar\u00edcano","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"2025112604222448700_ref4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.ijrobp.2015.10.054","article-title":"Factors influencing pulmonary toxicity in children undergoing allogeneic hematopoietic stem cell transplantation in the setting of total body irradiation-based myeloablative conditioning","volume":"94","author":"Abugideiri","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025112604222448700_ref5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.radonc.2020.10.032","article-title":"Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers. 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