{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:49:50Z","timestamp":1784742590920,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2023YFE0197700"],"award-info":[{"award-number":["2023YFE0197700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>4-Borono-L-phenylalanine (BPA) is a key 10B carrier used in boron neutron capture therapy (BNCT), while its PET tracer analogue, 4-borono-2-18F-fluoro-L-phenylalanine (18F-BPA), enables non-invasive visualization of tumour boron uptake. Since BNCT efficacy depends on precise tumour boron accumulation, we evaluated whether 18F-BPA mirrors BPA\u2019s transport and biodistribution. In vitro, BPA exhibited a highly consistent uptake profile with its non-radioactive fluorinated analogue, 2-19F-4-borono-L-phenylalanine (19F-BPA), across nine cancer cell lines (r\u2009=\u20090.9455, P\u2009&amp;lt;\u20090.001) and tri-iodothyronine (T3)-mediated LAT-1 inhibition markedly reduced the uptake of both BPA and 19F-BPA. In vivo, BPA and 18F-BPA showed predominant accumulation in the kidneys and pancreas in Sprague\u2013Dawley rats, with substantially lower levels detected in other organs. Importantly, in tumour-bearing mice, the time-concentration curve of BPA and the time-activity curve of 18F-BPA in tumours were found to be highly consistent, and showed a corresponding relationship between BPA concentration and 18F-BPA activity in terms of accumulation in tumour, blood, and muscle (r\u2009=\u20090.9623, P\u2009&amp;lt;\u20090.0001). Collectively, these findings confirm that BPA and 18F-BPA not only share LAT-1-mediated transport mechanisms, but also exhibit similar pharmacokinetics and tumour-specific accumulation. This substantiates the use of 18F-BPA as a reliable surrogate for visualizing BPA biodistribution and optimizing patient-specific BNCT treatment planning.<\/jats:p>","DOI":"10.1093\/jrr\/rraf070","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T17:56:19Z","timestamp":1763574979000},"page":"11-19","source":"Crossref","is-referenced-by-count":3,"title":["18F-BPA as a surrogate tracer for BPA in BNCT: comparative analysis of transport mechanisms and biodistribution"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8769-2449","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"Neuboron Bio-SciTech Co., Ltd. , Floor 1 and 5, Building B6, Xiamen Biology Medicine Industrial Park, 2060 West Wengjiao Road, Haicang Dist., Xiamen City, Fujian Province, 361000 ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Sun","sequence":"additional","affiliation":[{"name":"Neuboron Bio-SciTech Co., Ltd. , Floor 1 and 5, Building B6, Xiamen Biology Medicine Industrial Park, 2060 West Wengjiao Road, Haicang Dist., Xiamen City, Fujian Province, 361000 ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Lin","sequence":"additional","affiliation":[{"name":"Neuboron Bio-SciTech Co., Ltd. , Floor 1 and 5, Building B6, Xiamen Biology Medicine Industrial Park, 2060 West Wengjiao Road, Haicang Dist., Xiamen City, Fujian Province, 361000 ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neuboron Bio-SciTech Co., Ltd. , Floor 1 and 5, Building B6, Xiamen Biology Medicine Industrial Park, 2060 West Wengjiao Road, Haicang Dist., Xiamen City, Fujian Province, 361000 ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9923-9220","authenticated-orcid":false,"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Neuboron Bio-SciTech Co., Ltd. , Floor 1 and 5, Building B6, Xiamen Biology Medicine Industrial Park, 2060 West Wengjiao Road, Haicang Dist., Xiamen City, Fujian Province, 361000 ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-0002","authenticated-orcid":false,"given":"Yuanhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuboron Therapy System Ltd. Floor 1 and 5, Building B6, Xiamen Biology Medicine Industrial Park , 2060 West Wengjiao Road, Haicang Dist., Xiamen City, Fujian Province, 361000 ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"2026013002570454900_ref1","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1158\/1078-0432.CCR-05-0035","article-title":"Boron neutron capture therapy of cancer: current status and future prospects","volume":"11","author":"Barth","year":"2005","journal-title":"Clin Cancer Res"},{"key":"2026013002570454900_ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40880-018-0299-7","article-title":"Boron delivery agents for neutron capture therapy of cancer","volume":"38","author":"Barth","year":"2018","journal-title":"Cancer Commun 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