{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:24:19Z","timestamp":1790742259959,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["23H01391"],"award-info":[{"award-number":["23H01391"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have previously reported that the localized application of gaseous plasma to normal tissues suppresses distant tumor growth in mice, resembling the abscopal effect of radiotherapy. Plasma, a partially ionized gas generated by a high-voltage electrical discharge, is fundamentally distinct from ionizing radiation and produces diverse reactive oxygen and nitrogen species that interact with biological tissues. This study examined the abscopal-like effects of normal tissue plasma treatment in BALB\/c mice with subcutaneous Colon 26 tumors. The left dorsal skin, 2\u20133\u00a0cm from the tumor, was exposed to plasma for 10\u00a0min per day for 5 consecutive days, which delayed the growth of distant tumors. Similar tumor suppression was observed with abdominal exposure, indicating that the effect was not site-specific. In C.B-17 SCID mice (lacking T and B cells) and BALB\/c nu\/nu mice (lacking T cells), dorsal treatment did not suppress tumor growth, suggesting that T cells are likely involved in the response. Flow cytometric analysis of tumor-infiltrating immune cells in BALB\/c mice revealed significant reductions in macrophages and increases in monocytes, with a possible but nonsignificant increase in dendritic cells. No consistent changes were detected in CD8+ T-cell proportion or ICOS (inducible T-cell costimulatory) expression. However, the lack of antitumor effects in immunodeficient mice suggests that CD8+ T cells are involved.<\/jats:p>","DOI":"10.1093\/jrr\/rraf077","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:13:20Z","timestamp":1762434800000},"page":"50-58","source":"Crossref","is-referenced-by-count":2,"title":["Abscopal-like antitumor effect induced by localized low-temperature plasma application of normal tissue in mice"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0105-5399","authenticated-orcid":false,"given":"Ryo","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Advanced Energy, The University of Tokyo , 5-1-5 Kashiwanoha, Kashiwa, Chiba 227-8568 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"Department of Advanced Energy, The University of Tokyo , 5-1-5 Kashiwanoha, Kashiwa, Chiba 227-8568 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Advanced Energy, The University of Tokyo , 5-1-5 Kashiwanoha, Kashiwa, Chiba 227-8568 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reima","family":"Jinno","sequence":"additional","affiliation":[{"name":"Department of Advanced Energy, The University of Tokyo , 5-1-5 Kashiwanoha, Kashiwa, Chiba 227-8568 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Yanai","sequence":"additional","affiliation":[{"name":"Department of Inflammology, Research Center for Advanced Science and Technology, The University of Tokyo , 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 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