{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:48:42Z","timestamp":1789681722340,"version":"4.0.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K15017"],"award-info":[{"award-number":["JP21K15017"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H04927"],"award-info":[{"award-number":["JP21H04927"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K160760"],"award-info":[{"award-number":["JP22K160760"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K080290"],"award-info":[{"award-number":["JP21K080290"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K11240"],"award-info":[{"award-number":["JP24K11240"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K07641"],"award-info":[{"award-number":["JP19K07641"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K07212"],"award-info":[{"award-number":["JP22K07212"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H03373"],"award-info":[{"award-number":["JP18H03373"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H04927"],"award-info":[{"award-number":["JP21H04927"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tsuchiya Memorial Medical Foundation"},{"name":"Research Center for Radiation Disaster Medical Science of Hiroshima University"},{"name":"Nagasaki University and Fukushima Medical University"},{"name":"Program of the Joint Usage\/Research Center of Kyoto University"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["JP25HP2001"],"award-info":[{"award-number":["JP25HP2001"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Computed tomography (CT) is indispensable in clinical practice, but the health risks of repeated low-dose radiation exposure remain unclear, especially in relation to potential differences between cancer and non-cancer patients. This study aimed to examine potential differences in biological responses to CT-associated low-dose irradiation between non-cancer patients and patients with hepatocellular carcinoma (HCC). In a prospective observational study, chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBLs) were quantified by fluorescence in situ hybridization analysis with peptide nucleic acid probes (PNA-FISH). Data from 60 non-cancer patients obtained in our previous study were used as control, and 61 HCC patients were newly enrolled. Baseline CA frequencies were significantly higher in HCC patients (30.6 per 1000 cells) than in non-cancer patients (5.6 per 1000 cells; P\u2009&amp;lt;\u20090.0001). Among the 61 HCC patients, those with a history of radiotherapy (RT) exhibited higher baseline CAs (64.8 per 1000 cells) compared with those without RT (n\u2009=\u200949; 22.2 per 1000 cells). In RT-negative HCC patients, a history of TACE also correlated with increased baseline CAs (P\u2009&amp;lt;\u20090.05), suggesting a contribution of prior genotoxic therapies. In HCC patients without prior RT, a history of TACE also correlated with increased baseline CAs (P\u2009&amp;lt;\u20090.05), suggesting a contribution of prior genotoxic therapies. In addition, Notably, CT-induced CA formation was greater in HCC patients with prior RT than in patients without RT (P\u2009&amp;lt;\u20090.05). These results support careful assessment of cumulative medical radiation exposure in cancer patients who undergo repeated imaging and\/or treatment.<\/jats:p>","DOI":"10.1093\/jrr\/rrag014","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:38:20Z","timestamp":1771418300000},"page":"556-567","source":"Crossref","is-referenced-by-count":1,"title":["Radiation effects of a CT scan on chromosomal aberrations in cancer and non-cancer patients"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-0219","authenticated-orcid":false,"given":"Yuri","family":"Kawashima","sequence":"first","affiliation":[{"name":"Research Institute for Radiation Biology and Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong 271000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Graduate School of Biomedical and Health Science, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Research Institute for Radiation Biology Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Research Institute for Radiation Biology Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiemi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]},{"name":"Department of Health and Nutrition, Faculty of Health Sciences, Hiroshima Shudo University , 1-1-1 Oozuka-Higashi, Asaminami-ku, Hiroshima 731-3195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Fukushima Medical University , 1 Hikarigaoka, Fukushima 960-1295 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloriamaris","family":"Loy-Caraos","sequence":"additional","affiliation":[{"name":"Philippine Nuclear Research Institute, Department of Science and Technology , Commonwealth Avenue, Diliman, Quezon City 1101 ,","place":["Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namkhai","family":"Bayasgalan","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Research Institute for Radiation Biology Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvd","family":"Bayarjargal","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Research Institute for Radiation Biology Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Research Institute for Radiation Biology Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aikata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Hiroshima Prefectural Hospital , 1-5-54 Ujina-Kanda, Minami-ku, Hiroshima 734-8530 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-0240","authenticated-orcid":false,"given":"Shinji","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Radiation Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Hiroshima Institute of Life Sciences , 7-21 Nishi-Asahi-machi, Minami-ku, Hiroshima 734-0002 ,","place":["Japan"]},{"name":"RIKEN Center for Integrative Medical Sciences , 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Awai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Graduate School of Biomedical and Health Science, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-157X","authenticated-orcid":false,"given":"Satoshi","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Research Institute for Radiation Biology Medicine, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"2026072501213861200_ref1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1080\/09553000902883836","article-title":"Ionising radiation and cancer risks: what have we learned from epidemiology?","volume":"85","author":"Gilbert","year":"2009","journal-title":"Int J Radiat Biol"},{"key":"2026072501213861200_ref2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1667\/RR3049","article-title":"Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950\u20131997","volume":"160","author":"Preston","year":"2003","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1667\/RR3232","article-title":"Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates","volume":"162","author":"Preston","year":"2004","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1667\/RR0763.1","article-title":"Solid cancer incidence in atomic bomb survivors: 1958\u20131998","volume":"168","author":"Preston","year":"2007","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1667\/0033-7587(2000)154[0178:RRCRAL]2.0.CO;2","article-title":"Radiation-related cancer risks at low doses among atomic bomb survivors","volume":"154","author":"Pierce","year":"2000","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref6","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nrc2677","article-title":"Assessing cancer risks of low-dose radiation","volume":"9","author":"Mullenders","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"2026072501213861200_ref7","volume-title":"Radiobiology for the Radiologist","author":"Hall","year":"2012","edition":"7th"},{"key":"2026072501213861200_ref8","first-page":"1","article-title":"Low-dose extrapolation of radiation-related cancer risk","volume":"35","author":"Valentin","year":"2005","journal-title":"Ann ICRP"},{"key":"2026072501213861200_ref9","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1148\/radiol.14132478","article-title":"Intravenous iodinated contrast agents amplify DNA radiation damage at CT","volume":"275","author":"Piechowiak","year":"2015","journal-title":"Radiology"},{"key":"2026072501213861200_ref10","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMra072149","article-title":"Computed tomography \u2014 an increasing source of radiation exposure","volume":"357","author":"Brenner","year":"2007","journal-title":"N Engl J Med"},{"key":"2026072501213861200_ref11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1148\/radiol.2421060171","article-title":"Leukocyte DNA damage after multi\u2013detector row CT: a quantitative biomarker of low-level radiation exposure","volume":"242","author":"Rothkamm","year":"2007","journal-title":"Radiology"},{"key":"2026072501213861200_ref12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0140-6736(12)60815-0","article-title":"Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study","volume":"380","author":"Pearce","year":"2012","journal-title":"Lancet"},{"key":"2026072501213861200_ref13","doi-asserted-by":"publisher","first-page":"f2360","DOI":"10.1136\/bmj.f2360","article-title":"Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians","volume":"346","author":"Mathews","year":"2013","journal-title":"BMJ"},{"key":"2026072501213861200_ref14","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1038\/bjc.2014.103","article-title":"Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study","volume":"110","author":"Huang","year":"2014","journal-title":"Br J Cancer"},{"key":"2026072501213861200_ref15","first-page":"1239","article-title":"Risk of hematological malignancies from CT radiation exposure in children, adolescents, and young adults","volume":"21","author":"Journy","year":"2015","journal-title":"Nat Med"},{"key":"2026072501213861200_ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1470-2045(22)00655-6","article-title":"Brain cancer after radiation exposure from CT examinations of children and young adults: results from the EPI-CT cohort study","volume":"24","author":"Bosch de Basea","year":"2023","journal-title":"Lancet Oncol"},{"key":"2026072501213861200_ref17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3238\/arztebl.2011.0407","article-title":"Radiation protection in pediatric radiology","volume":"108","author":"Alzen","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"2026072501213861200_ref18","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3109\/09553002.2013.816451","article-title":"Human Radiosensitivity","volume":"89","author":"Morgan","year":"2013","journal-title":"Int J Radiat Biol"},{"key":"2026072501213861200_ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2249.2000.01257.x","article-title":"Immunodeficiency associated with DNA repair defects","volume":"121","author":"Gennery","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"2026072501213861200_ref20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.iac.2009.10.004","article-title":"Radiosensitive severe combined immunodeficiency disease","volume":"30","author":"Dvorak","year":"2010","journal-title":"Immunol Allergy Clin N Am"},{"key":"2026072501213861200_ref21","doi-asserted-by":"crossref","first-page":"834889","DOI":"10.3389\/fimmu.2022.834889","article-title":"The role of DNA repair in immunological diversity: from molecular mechanisms to clinical ramifications","volume":"13","author":"Gullickson","year":"2022","journal-title":"Front Immunol"},{"key":"2026072501213861200_ref22","doi-asserted-by":"crossref","first-page":"103594","DOI":"10.1016\/j.dnarep.2023.103594","article-title":"DNA repair deficiency and the immune microenvironment: a pathways perspective","volume":"133","author":"Zhou","year":"2024","journal-title":"DNA Repair"},{"key":"2026072501213861200_ref23","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1667\/RADE-20-00234.1","article-title":"Evaluating individual radiosensitivity for the prediction of acute toxicities of chemoradiotherapy in esophageal cancer patients","volume":"195","author":"Imano","year":"2020","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1148\/radiol.2020190389","article-title":"Biological effects of low-dose chest CT on chromosomal DNA","volume":"295","author":"Sakane","year":"2020","journal-title":"Radiology"},{"key":"2026072501213861200_ref25","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1667\/RR14976.1","article-title":"Chromosomal abnormalities in human lymphocytes after computed tomography scan procedure","volume":"190","author":"Shi","year":"2018","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref26","doi-asserted-by":"crossref","first-page":"13882","DOI":"10.1038\/srep13882","article-title":"Increase in dicentric chromosome formation after a single CT scan in adults","volume":"5","author":"Abe","year":"2015","journal-title":"Sci Rep"},{"key":"2026072501213861200_ref27","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1093\/jrr\/rrz068","article-title":"Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients","volume":"60","author":"Abe","year":"2019","journal-title":"J Radiat Res"},{"key":"2026072501213861200_ref28","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/biomedicines11041122","article-title":"Assessment of individual radiosensitivity in breast cancer patients using a combination of biomolecular markers","volume":"11","author":"Durdik","year":"2023","journal-title":"Biomedicines"},{"key":"2026072501213861200_ref29","volume-title":"Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies","author":"International Atomic Energy Agency"},{"key":"2026072501213861200_ref30","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/jemt.22512","article-title":"An automated imaging system for radiation biodosimetry","volume":"78","author":"Garty","year":"2015","journal-title":"Microsc Res Tech"},{"key":"2026072501213861200_ref31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00411-016-0647-4","article-title":"Cytogenetic effects of radioiodine therapy: a 20-year follow-up study","volume":"55","author":"Livingston","year":"2016","journal-title":"Radiat Environ Biophys"},{"key":"2026072501213861200_ref32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0027-5107(83)90019-2","article-title":"Effect of low-dose acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro","volume":"110","author":"Pohl-R\u00fcling","year":"1983","journal-title":"Mutat Res"},{"key":"2026072501213861200_ref33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/09553009214551021","article-title":"Chromosomal aberrations in human lymphocytes induced In vitro by very low doses of X-rays","volume":"61","author":"Lloyd","year":"1992","journal-title":"Int J Radiat Biol"},{"key":"2026072501213861200_ref34","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1667\/RR2097.1","article-title":"The dose response of chromosome aberrations in human lymphocytes induced In vitro by very low-dose \u03b3 rays","volume":"175","author":"Iwasaki","year":"2011","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref35","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1667\/RR2849.1","article-title":"A modified system for analyzing ionizing radiation-induced chromosome abnormalities","volume":"177","author":"Shi","year":"2012","journal-title":"Radiat Res"},{"key":"2026072501213861200_ref36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/cmmi.1567","article-title":"Influence of different iodinated contrast media on the induction of DNA double-strand breaks after in vitro X-ray irradiation","volume":"9","author":"Deinzer","year":"2014","journal-title":"Contrast Media Mol Imaging"},{"key":"2026072501213861200_ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.icrp.2007.09.001","article-title":"Benefits and costs, an eternal balance","volume":"37","author":"Dixon","year":"2007","journal-title":"Ann ICRP"},{"key":"2026072501213861200_ref38","volume-title":"Doses from Computed Tomography (CT) Examinations in the UK \u2013 2003 Review","author":"Shrimpton","year":"2005"},{"key":"2026072501213861200_ref39","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1289\/ehp.96104s3489","article-title":"The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents","volume":"104","author":"Tucker","year":"1996","journal-title":"Environ Health Perspect"},{"key":"2026072501213861200_ref40","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mrgentox.2008.01.005","article-title":"International study of factors affecting human chromosome translocations","volume":"652","author":"Sigurdson","year":"2008","journal-title":"Mutat Res"},{"key":"2026072501213861200_ref41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0921-8734(95)00015-X","article-title":"The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting","volume":"338","author":"Ramsey","year":"1995","journal-title":"Mutat Res"},{"key":"2026072501213861200_ref42","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1007\/s00261-024-04370-0","article-title":"Radiation dose during transarterial chemoembolization and associated factors","volume":"49","author":"Choi","year":"2024","journal-title":"Abdom Radiol"},{"key":"2026072501213861200_ref43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00411-009-0244-x","article-title":"Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients","volume":"49","author":"Hille","year":"2010","journal-title":"Radiat Environ Biophys"},{"key":"2026072501213861200_ref44","first-page":"75","article-title":"Analysis of the cytogenetic response in peripheral blood lymphocytes from breast cancer patients following chemotherapy","volume":"31","author":"Resende","year":"2010","journal-title":"Eur J Gynaecol Oncol"},{"key":"2026072501213861200_ref45","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ijrobp.2013.11.219","article-title":"Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity","volume":"88","author":"Oorschot","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jrr\/article-pdf\/67\/4\/556\/68429194\/rrag014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jrr\/article-pdf\/67\/4\/556\/68429194\/rrag014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:21:48Z","timestamp":1784956908000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/67\/4\/556\/8697774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,5,29]]},"published-print":{"date-parts":[[2026,7,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rrag014","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,5,29]]}}}