{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T06:00:59Z","timestamp":1784959259671,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the feasibility and safety of percutaneous fiducial marker placement using a 25G needle compared with transarterial placement before proton therapy for pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients who underwent fiducial marker placement from 2013 to 2023 were retrospectively reviewed. For percutaneous placement, a 25G needle was used to place markers in or around the tumor under computed tomography (CT) guidance. For transarterial placement, a metal coil was placed as a fiducial marker in a blood vessel near the tumor using a microcatheter. Technical success was defined as the reliable use of the placed fiducial marker throughout the entire proton therapy course. Major complications were defined as grade 3 or higher. Each outcome was compared using Fisher\u2019s exact test or the Mann\u2013Whitney U test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-nine and 60 patients underwent percutaneous and transarterial fiducial marker placement, respectively. The technical success rates were 89.8 and 90.0% for percutaneous and transarterial placement, respectively, with no statistically significant difference between them (P\u2009&amp;gt;\u20090.99). There were no major complications in either case. The median procedure time for percutaneous placement was significantly shorter than that for transarterial placement (3.3 vs 40.0\u00a0min; P\u2009&amp;lt;\u20090.001). The median distance between the marker and the tumor was shorter with percutaneous placement than with transarterial placement (0.0 vs 10.0\u00a0mm; P\u2009=\u20090.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Percutaneous placement of fiducial markers for pancreatic cancer proton therapy using a 25G needle could be performed faster than transarterial placement with a high success rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jrr\/rrag032","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:48:32Z","timestamp":1775130512000},"page":"577-583","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of percutaneous and transarterial fiducial marker placement before proton therapy for pancreatic cancer"],"prefix":"10.1093","volume":"67","author":[{"given":"Jumpei","family":"Shoji","sequence":"first","affiliation":[{"name":"Nagoya City University West Medical Center, Diagnostic Radiology Department , 462-8508, 1-1-1, Hirate-cho, kita-ku, Nagoya ,","place":["Japan"]},{"name":"Radiology Department, Nagoya City University Graduate School of Medical Sciences , 467-8601, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1509-6730","authenticated-orcid":false,"given":"Kengo","family":"Ohta","sequence":"additional","affiliation":[{"name":"Radiology Department, Nagoya City University Graduate School of Medical Sciences , 467-8601, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Radiology Department, Nagoya City University Graduate School of Medical Sciences , 467-8601, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Horibe","sequence":"additional","affiliation":[{"name":"Nagoya City University West Medical Center, Diagnostic Radiology Department , 462-8508, 1-1-1, Hirate-cho, kita-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Hatano","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Department, Midori Municipal Hospital , 458-0037, 1-77, Siomigaoka, Midori-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Murai","sequence":"additional","affiliation":[{"name":"Nagoya City University West Medical Center, Diagnostic Radiology Department , 462-8508, 1-1-1, Hirate-cho, kita-ku, Nagoya ,","place":["Japan"]},{"name":"Radiology Department, Nagoya City University Graduate School of Medical Sciences , 467-8601, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-7836","authenticated-orcid":false,"given":"Koichiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Nagoya Proton Therapy Center, Radiation Oncology Department, Nagoya City University West Medical Center , 462-8508, 1-1-1, Hirate-cho, kita-ku, Nagoya ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-9800","authenticated-orcid":false,"given":"Hiromitsu","family":"Iwata","sequence":"additional","affiliation":[{"name":"Nagoya Proton Therapy Center, Radiation Oncology Department, Nagoya City University West Medical Center , 462-8508, 1-1-1, Hirate-cho, kita-ku, Nagoya 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