{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:50:44Z","timestamp":1791546644521,"version":"4.3.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2024ZZ2054"],"award-info":[{"award-number":["2024ZZ2054"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pudong New Area Health Commission","award":["2025-PWYC-09"],"award-info":[{"award-number":["2025-PWYC-09"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0519900"],"award-info":[{"award-number":["2024ZD0519900"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0519901"],"award-info":[{"award-number":["2024ZD0519901"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study evaluates the dosimetric feasibility of carbon-ion radiation therapy (CIRT) for ocular melanoma (OM) using a local effect model-I\u2013based treatment planning system (TPS) combined with pencil beam scanning delivery. Cube-shaped targets were designed based on the experience of CIRT for OM at the National Institutes for Quantum Science and Technology (QST). Treatment plans used the local effect model-I\u2013based TPS (Syngo\u00ae V13C, SIEMENS, Germany) prescribing an absorbed dose consistent with values reported in the literature. A conversion factor (CF) was established to convert the QST dose to LEM based relative biological effectiveness (RBE)\u2013weighted dose. The physical doses were verified by an in-house Monte Carlo program and measurement. The CF for the LEM, equivalent to the QST RBE-prescribed dose of 70\u00a0Gy (RBE) over 5 fractions, was established as 0.65. The 3D gamma passing rate between TPS and MC was \u226594% using 3%\u20133\u00a0mm criteria. Mean dose deviations between the TPS and measurement were \u2264\u00b11.61% for all targets sizes except the smallest one (7\u00a0mm). Mean distance-to-agreement was &amp;lt;1\u00a0mm for all plans except one with a range shifter (distance-to-agreement\u2009=\u20092.92\u00a0mm). Phantom cases showed a lateral penumbra of 5.4\u20136.2\u00a0mm, and distal dose fall-off measures 3.6 and 5.6\u00a0mm. The results underscore the need for RBE-weighted dose conversion when applying QST\u2019s CIRT experience to OM treatment.<\/jats:p>","DOI":"10.1093\/jrr\/rrag062","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:36:59Z","timestamp":1782992219000},"page":"746-753","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system"],"prefix":"10.1093","volume":"67","author":[{"given":"Yuze","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixu","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Kong","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-9786","authenticated-orcid":false,"given":"Yinxiangzi","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Key Laboratory of Radiation Oncology (20dz2261000) , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]},{"name":"Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy , 4365 Kangxin Road, Pudong District, Shanghai 201315 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026100906565332700_ref1","first-page":"1230","article-title":"Ocular melanoma: an overview of the current status","volume":"6","author":"Jovanovic","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"2026100906565332700_ref2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.jaad.2019.10.024","article-title":"Risk of second primary cutaneous and non-cutaneous melanoma following cutaneous melanoma diagnosis: a population-based 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