{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:06:09Z","timestamp":1790701569514,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["23H01391"],"award-info":[{"award-number":["23H01391"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["26H02024"],"award-info":[{"award-number":["26H02024"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cold atmospheric-pressure plasma has been suggested to induce antitumor immune responses as a local anticancer treatment. In this study, we investigated whether streamer discharge plasma, a type of cold atmospheric-pressure plasma, enhances the antitumor effects of anti-programmed cell death protein 1 (PD-1) antibody therapy in a murine colon tumor model. Colon26 tumor-bearing mice were randomly assigned to four groups: Control, anti-PD-1 antibody alone, plasma treatment alone and combination treatment with anti-PD-1 antibody and plasma groups. Three independent tumor growth experiments were performed. Under conditions in which anti-PD-1 antibody and plasma treatments alone showed limited effects on tumor growth, the combination treatment delayed tumor growth. Analysis of longitudinal tumor growth curves using a linear mixed model revealed a significant interaction among time, anti-PD-1 antibody treatment and plasma treatment in the integrated dataset, supporting a combined effect on tumor growth. Exploratory flow cytometric analysis showed a numerically lower percentage of F4\/80+ macrophage-enriched cells and numerically higher percentages of CD8+ T cell-related populations in the combination group. However, no statistically significant interaction between plasma treatment and anti-PD-1 antibody treatment was detected for any of the flow cytometric parameters. Overall, the pooled analysis supported a combined antitumor effect of local streamer discharge plasma and anti-PD-1 antibody treatment, although the magnitude of the combined effect varied among the three experiments.<\/jats:p>","DOI":"10.1093\/jrr\/rrag079","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:15:57Z","timestamp":1786706157000},"source":"Crossref","is-referenced-by-count":0,"title":["Antitumor effects of combined local plasma and anti-PD-1 antibody treatment in a murine colon tumor model"],"prefix":"10.1093","author":[{"given":"Hiroki","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Advanced Energy, The University of Tokyo , 5-1-5 Kashiwanoha, Kashiwa, Chiba 227-8568 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Iizawa","sequence":"additional","affiliation":[{"name":"Department of Advanced Energy, The University of Tokyo , 5-1-5 Kashiwanoha, Kashiwa, 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