{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:11:33Z","timestamp":1792811493675,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We recently reported an increase in dicentric chromosome (DIC) formation after a single computed tomography (CT) scan (5.78\u201360.27 mSv: mean 24.24 mSv) and we recommended analysis of 2000 metaphase cells stained with Giemsa and centromere-FISH for dicentric chromosome assay (DCA) in cases of low-dose radiation exposure. In the present study, we analyzed the frequency of chromosome translocations using stored Carnoy's-fixed lymphocyte specimens from the previous study; these specimens were from 12 patients who were subject to chromosome painting of Chromosomes 1, 2 and 4. Chromosomes 1, 2 and 4 were analyzed in \u223c5000 cells, which is equivalent to the whole-genome analysis of almost 2000 cells. The frequency of chromosome translocation was higher than the number of DICs formed, both before and after CT scanning. The frequency of chromosome translocations tended to be higher, but not significantly higher, in patients with a treatment history compared with patients without such a history. However, in contrast to the results for DIC formation, the frequency of translocations detected before and after the CT scan did not differ significantly. Therefore, analysis of chromosome translocation may not be a suitable assay for detecting chromosome aberrations in cases of low-dose radiation exposure from a CT scan. A significant increase in the frequency of chromosome translocations was not likely to be detected due to the high baseline before the CT scan; the high and variable frequency of translocations was probably due to multiple confounding factors in adults.<\/jats:p>","DOI":"10.1093\/jrr\/rrv090","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T20:21:10Z","timestamp":1455394870000},"page":"220-226","source":"Crossref","is-referenced-by-count":26,"title":["Analysis of chromosome translocation frequency after a single CT scan in adults"],"prefix":"10.1093","volume":"57","author":[{"given":"Yu","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomisato","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki A.","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Ujiie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kurosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagisa","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Katafuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Tsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Inamasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Shishido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyoshi","family":"Noji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuei","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ohsugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"2020010903184363700_RRV090C1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(12)60815-0","article-title":"Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study","volume":"380","author":"Pearce","year":"2012","journal-title":"Lancet"},{"key":"2020010903184363700_RRV090C2","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f2360","article-title":"Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians","volume":"346","author":"Mathews","year":"2013","journal-title":"BMJ"},{"key":"2020010903184363700_RRV090C3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cll.2011.07.007","article-title":"Solid tumor cytogenetics: current perspectives","volume":"31","author":"Nanjangud","year":"2011","journal-title":"Clin Lab Med"},{"key":"2020010903184363700_RRV090C4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/leu.2015.32","article-title":"Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia","volume":"29","author":"Bochtler","year":"2015","journal-title":"Leukemia"},{"key":"2020010903184363700_RRV090C5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/bjh.13507","article-title":"Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy","volume":"171","author":"Krem","year":"2015","journal-title":"Br J Haematol"},{"key":"2020010903184363700_RRV090C6","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1073\/pnas.0501895102","article-title":"In vivo\n               formation and repair of DNA double-strand breaks after computed tomography examinations","volume":"102","author":"L\u00f6brich","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020010903184363700_RRV090C7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/09553000701283816","article-title":"Enhanced yield of chromosome aberrations after CT examinations in paediatric patients","volume":"83","author":"Stephan","year":"2007","journal-title":"Int J Radiat Biol"},{"key":"2020010903184363700_RRV090C8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1148\/radiol.2421060171","article-title":"Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure","volume":"242","author":"Rothkamm","year":"2007","journal-title":"Radiology"},{"key":"2020010903184363700_RRV090C9","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00330-012-2426-1","article-title":"DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study","volume":"22","author":"Geisel","year":"2012","journal-title":"Eur Radiol"},{"key":"2020010903184363700_RRV090C10","volume-title":"Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies, EPR-Biodosimetry","author":"IAEA","year":"2011"},{"key":"2020010903184363700_RRV090C11","doi-asserted-by":"crossref","first-page":"13882","DOI":"10.1038\/srep13882","article-title":"Increase in dicentric chromosome formation after a single CT scan in adults","volume":"5","author":"Abe","year":"2015","journal-title":"Sci Rep"},{"key":"2020010903184363700_RRV090C12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/095530096145445","article-title":"Comparison of the yields of translocations and dicentrics measured using conventional Giemsa staining and chromosome painting","volume":"69","author":"Kanda","year":"1996","journal-title":"Int J Radiat Biol"},{"key":"2020010903184363700_RRV090C13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10038-003-0071-x","article-title":"Preferential reduction of dicentrics in reciprocal exchanges due to the combination of the size of broken chromosome segments by radiation","volume":"48","author":"Zhang","year":"2003","journal-title":"J Hum Genet"},{"key":"2020010903184363700_RRV090C14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1748-720X.1991.tb01822.x","article-title":"International guidelines for ethical review of epidemiological studies","volume":"19","author":"Council for International Organizations of Medical Sciences","year":"1991","journal-title":"Law Med Health Care"},{"key":"2020010903184363700_RRV090C15","article-title":"Cytogenetic analysis for radiation dose assessment. A manual","volume-title":"Technical Reports Series No. 405","author":"IAEA","year":"2001"},{"key":"2020010903184363700_RRV090C16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/09553000050028968","article-title":"Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe","volume":"76","author":"Fomina","year":"2000","journal-title":"Int J Radiat Biol"},{"key":"2020010903184363700_RRV090C17","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/09553000110050065","article-title":"Detection of stable chromosome aberrations by FISH in A-bomb survivors: comparison with previous solid Giemsa staining data on the same 230 individuals","volume":"77","author":"Nakano","year":"2001","journal-title":"Int J Radiat Biol"},{"key":"2020010903184363700_RRV090C18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/25292","article-title":"Genetic instability in human cancers","volume":"396","author":"Lengauer","year":"1998","journal-title":"Nature"},{"key":"2020010903184363700_RRV090C19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2014.12.038","article-title":"DNA damage response\u2014a double-edged sword in cancer prevention and cancer therapy","volume":"358","author":"Tian","year":"2015","journal-title":"Cancer Lett"},{"key":"2020010903184363700_RRV090C20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0921-8734(95)00015-X","article-title":"The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting","volume":"338","author":"Ramsey","year":"1995","journal-title":"Mutat Res"},{"key":"2020010903184363700_RRV090C21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2307\/3579605","article-title":"Biological dosimetry of radiation workers at the Sellafield nuclear facility","volume":"148","author":"Tucker","year":"1997","journal-title":"Radiat Res"},{"key":"2020010903184363700_RRV090C22","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2307\/3579324","article-title":"A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points","volume":"148","author":"Moore","year":"1997","journal-title":"Radiat Res"},{"key":"2020010903184363700_RRV090C23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2307\/3579859","article-title":"Do recorded doses overestimate true doses received by Chernobyl cleanup workers? Results of cytogenetic analyses of Estonian workers by fluorescence \n              in situ\n               hybridization","volume":"150","author":"Littlefield","year":"1998","journal-title":"Radiat Res"},{"key":"2020010903184363700_RRV090C24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000077496","article-title":"Effect of high-level natural radiation on chromosomes of residents in southern China","volume":"104","author":"Hayata","year":"2004","journal-title":"Cytogenet Genome Res"},{"key":"2020010903184363700_RRV090C25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1269\/jrr.45.441","article-title":"Effect of smoking on chromosomes compared with that of radiation in the residents of a high-background radiation area in China","volume":"45","author":"Zhang","year":"2004","journal-title":"J Radiat Res"},{"key":"2020010903184363700_RRV090C26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1269\/jrr.41.S63","article-title":"Dose\u2013effect relationship of dicentric and ring chromosomes in lymphocytes of individuals living in the high background radiation areas in China","volume":"41","author":"Jiang","year":"2000","journal-title":"J Radiat Res"},{"key":"2020010903184363700_RRV090C27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/bjc.2014.526","article-title":"Are the studies on cancer risk from CT scans biased by indication? Elements of answer from a large-scale cohort study in France","volume":"112","author":"Journy","year":"2015","journal-title":"Br J Cancer"},{"key":"2020010903184363700_RRV090C28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1667\/RR3311","article-title":"A hypothesis: radiation-related leukemia is mainly attributable to the small number of people who carry pre-existing clonally expanded preleukemic cells","volume":"163","author":"Nakamura","year":"2005","journal-title":"Radiat Res"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/57\/3\/220\/31614819\/rrv090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/57\/3\/220\/31614819\/rrv090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T03:28:14Z","timestamp":1578540494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/57\/3\/220\/2580279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,6,21]]},"published-print":{"date-parts":[[2016,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rrv090","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,6]]},"published":{"date-parts":[[2016,6,1]]}}}