{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:43:10Z","timestamp":1769107390201,"version":"3.49.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000104","name":"National Aeronautics and Space Administration","doi-asserted-by":"publisher","award":["NCC9-79"],"award-info":[{"award-number":["NCC9-79"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Radiation Medicine of the Loma Linda University Medical Center"},{"name":"Department of Basic Sciences at Loma Linda University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High-energy particle radiation could have a considerable impact on health during space missions. This study evaluated C57BL\/6 mice on Day 40 after total-body 56 Fe 26+ irradiation at 0, 1, 2 and 3 gray (Gy). Radiation consistently increased thymus mass (one-way ANOVA: P \u00a0&amp;lt;\u00a00.005); spleen, liver and lung masses were similar among all groups. In the blood, there was no radiation effect on the white blood cell (WBC) count or major leukocyte types. However, the red blood cell count, hemoglobin, hematocrit and the CD8+ T cytotoxic (Tc) cell count and percentage all decreased, while both the CD4:CD8 (Th:Tc) cell ratio and spontaneous blastogenesis increased, in one or more irradiated groups compared with unirradiated controls ( P \u00a0&amp;lt;\u00a00.05 vs 0 Gy). In contrast, splenic WBC, lymphocyte, B cell and T helper (Th) counts, %B cells and the CD4:CD8 ratio were all significantly elevated, while Tc percentages decreased, in one or more of the irradiated groups compared with controls ( P \u00a0&amp;lt;\u00a00.05 vs 0 Gy). Although there were trends for minor, radiation-induced increases in %CD11b+ granulocytes in the spleen, cells double-labeled with adhesion markers (CD11b+CD54+, CD11b+CD62E+) were normal. Splenocyte spontaneous blastogenesis and that induced by mitogens (PHA, ConA, LPS) was equivalent to normal. In bone marrow, the percentage of cells expressing stem cell markers, Sca-1 and CD34\/Sca-1, were low in one or more of the irradiated groups ( P \u00a0&amp;lt;\u00a00.05 vs 0 Gy). Collectively, the data indicate that significant immunological abnormalities still exist more than a month after 56 Fe irradiation and that there are differences dependent upon body compartment.<\/jats:p>","DOI":"10.1093\/jrr\/rrw051","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T22:29:17Z","timestamp":1467757757000},"page":"477-491","source":"Crossref","is-referenced-by-count":11,"title":["Changes in the distribution and function of leukocytes after whole-body iron ion irradiation"],"prefix":"10.1093","volume":"57","author":[{"given":"Daila S.","family":"Gridley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Pecaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,9,30]]},"reference":[{"key":"2020010903081032400_rrw051C1","author":"NCRP","year":"2006"},{"key":"2020010903081032400_rrw051C2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/life4030491","article-title":"Space radiation: the number one risk to astronaut health beyond low earth orbit","volume":"4","author":"Chancellor","year":"2014","journal-title":"Life"},{"key":"2020010903081032400_rrw051C3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/HP.0000000000000255","article-title":"Review of NASA approach to space radiation risk assessments for Mars exploration","volume":"108","author":"Cucinotta","year":"2015","journal-title":"Health Phys"},{"key":"2020010903081032400_rrw051C4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.lssr.2015.03.001","article-title":"Measurements of the neutron spectrum in transit to Mars on the Mars Science Laboratory","volume":"5","author":"Kohler","year":"2015","journal-title":"Life Sci Space Res"},{"key":"2020010903081032400_rrw051C5","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.1235989","article-title":"Measurements of energetic particle radiation in transit to Mars on the Mars Science Laboratory","volume":"340","author":"Zeitlin","year":"2013","journal-title":"Science"},{"key":"2020010903081032400_rrw051C6","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-22272-6","volume-title":"Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies","author":"Chouker","year":"2012"},{"key":"2020010903081032400_rrw051C7","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1152\/japplphysiol.91361.2008","article-title":"Effects of spaceflight on innate immune function and antioxidant gene expression","volume":"106","author":"Baqai","year":"2009","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s10875-012-9824-7","article-title":"Immune system dysregulation occurs during short duration spaceflight on board the space shuttle","volume":"33","author":"Crucian","year":"2013","journal-title":"J Clin Immunol"},{"key":"2020010903081032400_rrw051C9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1089\/jir.2013.0129","article-title":"Plasma cytokine concentrations indicate that \n              in vivo\n               hormonal regulation of immunity is altered during long-duration spaceflight","volume":"34","author":"Crucian","year":"2014","journal-title":"J Interferon Cytokine Res"},{"key":"2020010903081032400_rrw051C10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1667\/0033-7587(2001)156[0731:CAITBL]2.0.CO;2","article-title":"Chromosome aberrations in the blood lymphocytes of astronauts after space flight","volume":"156","author":"George","year":"2001","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C11","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/japplphysiol.01053.2002","article-title":"Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL\/6 mouse. II. Activation, cytokines, erythrocytes, and platelets","volume":"94","author":"Gridley","year":"2003","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1152\/japplphysiol.91126.2008","article-title":"Spaceflight effects on T lymphocyte distribution, function and gene expression","volume":"106","author":"Gridley","year":"2009","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C13","doi-asserted-by":"crossref","first-page":"e75097","DOI":"10.1371\/journal.pone.0075097","article-title":"Changes in mouse thymus and spleen after return from the STS-135 mission in space","volume":"8","author":"Gridley","year":"2013","journal-title":"PloS One"},{"key":"2020010903081032400_rrw051C14","doi-asserted-by":"crossref","first-page":"e0124380","DOI":"10.1371\/journal.pone.0124380","article-title":"Post-spaceflight (STS-135) mouse splenocytes demonstrate altered activation properties and surface molecule expression","volume":"10","author":"Hwang","year":"2015","journal-title":"PloS One"},{"key":"2020010903081032400_rrw051C15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jlb.54.3.189","article-title":"Immune changes during long-duration missions","volume":"54","author":"Konstantinova","year":"1993","journal-title":"J Leukoc Biol"},{"key":"2020010903081032400_rrw051C16","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1152\/japplphysiol.91138.2008","article-title":"Shifts in bone marrow cell phenotypes caused by spaceflight","volume":"106","author":"Ortega","year":"2009","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C17","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1152\/japplphysiol.01052.2002","article-title":"Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL\/6 mouse. I. Immune population distributions","volume":"94","author":"Pecaut","year":"2003","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1667\/RR13887.1","article-title":"Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice","volume":"183","author":"Chang","year":"2015","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/153303461000900612","article-title":"Low-dose photon and simulated solar particle event proton effects on Foxp\n              3+\n               T regulatory cells and other leukocytes","volume":"9","author":"Gridley","year":"2010","journal-title":"Technol Cancer Res Treat"},{"key":"2020010903081032400_rrw051C20","first-page":"159","article-title":"Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons","volume":"22","author":"Gridley","year":"2008","journal-title":"In Vivo"},{"key":"2020010903081032400_rrw051C21","doi-asserted-by":"crossref","first-page":"e0120126","DOI":"10.1371\/journal.pone.0120126","article-title":"Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight","volume":"10","author":"Li","year":"2015","journal-title":"PloS One"},{"key":"2020010903081032400_rrw051C22","doi-asserted-by":"crossref","first-page":"e85665","DOI":"10.1371\/journal.pone.0085665","article-title":"Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections","volume":"9","author":"Li","year":"2014","journal-title":"PloS One"},{"key":"2020010903081032400_rrw051C23","doi-asserted-by":"crossref","first-page":"R480","DOI":"10.1152\/ajpregu.00449.2014","article-title":"Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation","volume":"308","author":"Martinez","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020010903081032400_rrw051C24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3109\/09553002.2014.899445","article-title":"Impact of total-body irradiation on the response to a live bacterial challenge","volume":"90","author":"Pecaut","year":"2014","journal-title":"Int J Radiat Biol"},{"key":"2020010903081032400_rrw051C25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1152\/japplphysiol.01304.2003","article-title":"Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses","volume":"97","author":"Pecaut","year":"2004","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1269\/jrr.10107","article-title":"Low-dose gamma-rays and simulated solar particle event protons modify splenocyte gene and cytokine expression patterns","volume":"52","author":"Rizvi","year":"2011","journal-title":"J Radiat Res"},{"key":"2020010903081032400_rrw051C27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/09553002.2010.518206","article-title":"Low-dose gamma-rays modify CD4\n              +\n               T cell signalling response to simulated solar particle event protons in a mouse model","volume":"87","author":"Rizvi","year":"2011","journal-title":"Int J Radiat Biol"},{"key":"2020010903081032400_rrw051C28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.lssr.2014.01.003","article-title":"Acute hematological effects in mice exposed to the expected doses, dose-rates, and energies of solar particle event\u2013like proton radiation","volume":"2","author":"Sanzari","year":"2014","journal-title":"Life Sci Space Res"},{"key":"2020010903081032400_rrw051C29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/09553002.2012.639434","article-title":"Accelerated hematopoietic toxicity by high energy \n              56\n              Fe radiation","volume":"88","author":"Datta","year":"2012","journal-title":"Int J Radiat Biol"},{"key":"2020010903081032400_rrw051C30","first-page":"781","article-title":"Whole-body irradiation and long-term modification of bone marrow\u2013derived cell populations by low- and high-LET radiation","volume":"20","author":"Gridley","year":"2006","journal-title":"In Vivo"},{"key":"2020010903081032400_rrw051C31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00411-014-0513-1","article-title":"Directional genomic hybridization: inversions as a potential biodosimeter for retrospective radiation exposure","volume":"53","author":"Ray","year":"2014","journal-title":"Radiat Environ Biophys"},{"key":"2020010903081032400_rrw051C32","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1089\/ars.2013.5649","article-title":"Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles","volume":"20","author":"Li","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"2020010903081032400_rrw051C33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1667\/RR3490.1","article-title":"Acute effects of iron radiation on immunity, part II: leukocyte activation, cytokines, and adhesion","volume":"165","author":"Gridley","year":"2006","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/09553002.2010.518203","article-title":"Genetic background and lymphocyte populations after total-body exposure to iron ion radiation","volume":"87","author":"Gridley","year":"2011","journal-title":"Int J Radiat Biol"},{"key":"2020010903081032400_rrw051C35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1667\/RR3493.1","article-title":"Acute effects of iron radiation on immunity, part I: population distributions","volume":"165","author":"Pecaut","year":"2006","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C36","doi-asserted-by":"crossref","first-page":"R677","DOI":"10.1152\/ajpregu.00435.2001","article-title":"Total-body irradiation with high-LET particles: acute and chronic effects on the immune system","volume":"282","author":"Gridley","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020010903081032400_rrw051C37","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2307\/3579902","article-title":"Detailed characterization of the 1087 MeV\/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron","volume":"149","author":"Zeitlin","year":"1998","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1103\/PhysRevC.56.388","article-title":"Heavy fragment production cross sections from 1.05 GeV\/nucleon \n              56\n              Fe in C, Al, Cu, Pb, and CH2 targets","volume":"56","author":"Zeitlin","year":"1997","journal-title":"Phys Rev C Nucl Phys"},{"key":"2020010903081032400_rrw051C39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000048249","article-title":"Lymphocyte activation with localized pGL1-TNF-alpha gene therapy in a glioma model","volume":"62","author":"Gridley","year":"2002","journal-title":"Oncology"},{"key":"2020010903081032400_rrw051C40","first-page":"525","article-title":"Effects of proton and gamma radiation on lymphocyte populations and acute response to antigen","volume":"13","author":"Kajioka","year":"1999","journal-title":"In Vivo"},{"key":"2020010903081032400_rrw051C41","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/09553000903567995","article-title":"The impact of mouse strain on iron ion radio-immune response of leukocyte populations","volume":"86","author":"Pecaut","year":"2010","journal-title":"Int J Radiat Biol"},{"key":"2020010903081032400_rrw051C42","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/09553000802203614","article-title":"Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation","volume":"84","author":"Gridley","year":"2008","journal-title":"Int J Radiat Biol"},{"key":"2020010903081032400_rrw051C43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1667\/RR0832.1","article-title":"Bone architectural and structural properties after \n              56\n              Fe\n              26+\n               radiation-induced changes in body mass","volume":"170","author":"Willey","year":"2008","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00002030-199704000-00002","article-title":"HIV-1 and the thymus","volume":"11","author":"Gaulton","year":"1997","journal-title":"AIDS"},{"key":"2020010903081032400_rrw051C45","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/00002030-200205240-00003","article-title":"Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone","volume":"16","author":"Napolitano","year":"2002","journal-title":"AIDS"},{"key":"2020010903081032400_rrw051C46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2307\/3579443","article-title":"A versatile and rapid assay of radiosensitivity of peripheral blood leukocytes based on DNA and surface-marker assessment of cytotoxicity","volume":"147","author":"Crompton","year":"1997","journal-title":"Radiat Res"},{"key":"2020010903081032400_rrw051C47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1089\/cbr.2010.0907","article-title":"Beta androstenediol mitigates the damage of 1 GeV\/n Fe ion particle radiation to the hematopoietic system","volume":"26","author":"Loria","year":"2011","journal-title":"Cancer Biother Radiopharm"},{"issue":"10 Suppl","key":"2020010903081032400_rrw051C48","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1097\/00005768-199610000-00032","article-title":"Destruction of newly released red blood cells in space flight","volume":"28","author":"Alfrey","year":"1996","journal-title":"Med Sci Sports Exerc"},{"key":"2020010903081032400_rrw051C49","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1001\/jama.1967.03120200057007","article-title":"Red blood cell mass and plasma volume changes in manned space flight","volume":"200","author":"Fischer","year":"1967","journal-title":"JAMA"},{"key":"2020010903081032400_rrw051C50","first-page":"2285","article-title":"Influence of space flight on red blood cells","volume":"45","author":"Talbot","year":"1986","journal-title":"Fed Proc"},{"key":"2020010903081032400_rrw051C51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fphys.2014.00054","article-title":"Neocytolysis: none, one or many? A reappraisal and future perspectives","volume":"5","author":"Risso","year":"2014","journal-title":"Front Physiol"},{"key":"2020010903081032400_rrw051C52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<45::AID-CYTO6>3.0.CO;2-I","article-title":"Relative alterations in blood mononuclear cell populations reflect radiation injury in mice","volume":"31","author":"Chambers","year":"1998","journal-title":"Cytometry"},{"key":"2020010903081032400_rrw051C53","first-page":"195","article-title":"Dose and dose-rate effects of whole-body \u03b3-irradiation: I. Lymphocytes and lymphoid organs","volume":"15","author":"Pecaut","year":"2001","journal-title":"In Vivo"},{"key":"2020010903081032400_rrw051C54","first-page":"528","article-title":"Flow cytometric analysis of lymphocyte surface markers following a 1-Gy dose of gamma radiation","volume":"64","author":"Rowley","year":"1993","journal-title":"Aviat Space Environ Med"},{"key":"2020010903081032400_rrw051C55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-2478(01)00306-6","article-title":"Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: Part I","volume":"80","author":"Gridley","year":"2002","journal-title":"Immunol Lett"},{"key":"2020010903081032400_rrw051C56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.autrev.2012.07.011","article-title":"Potential roles for CD8\n              +\n               T cells in rheumatoid arthritis","volume":"12","author":"Carvalheiro","year":"2013","journal-title":"Autoimmun Rev"},{"key":"2020010903081032400_rrw051C57","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s40629-015-0038-4","article-title":"Change of paradigm: CD8\n              +\n               T cells as important helper for CD4\n              +\n               T cells during asthma and autoimmune encephalomyelitis","volume":"24","author":"Huber","year":"2015","journal-title":"Allergo J Int"},{"key":"2020010903081032400_rrw051C58","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000360163","article-title":"Lymphocyte-based model systems for allergy research: a historic overview","volume":"163","author":"Neunkirchner","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"2020010903081032400_rrw051C59","doi-asserted-by":"crossref","first-page":"e20219","DOI":"10.1371\/journal.pone.0020219","article-title":"CD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow","volume":"6","author":"Yang","year":"2011","journal-title":"PloS One"},{"key":"2020010903081032400_rrw051C60","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1242\/jcs.037507","article-title":"Novel functions of the CD34 family","volume":"121","author":"Nielsen","year":"2008","journal-title":"J Cell Sci"},{"key":"2020010903081032400_rrw051C61","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1634\/stemcells.2006-0644","article-title":"Concise review: stem cell antigen-1: expression, function, and enigma","volume":"25","author":"Holmes","year":"2007","journal-title":"Stem Cells"},{"key":"2020010903081032400_rrw051C62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clim.2008.11.003","article-title":"Analysis of \n              in vitro\n               lymphocyte proliferation as a screening tool for cellular immunodeficiency","volume":"131","author":"Stone","year":"2009","journal-title":"Clin Immunol"},{"key":"2020010903081032400_rrw051C63","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0171-2985(81)80087-3","article-title":"Spontaneous and conA-induced suppressor lymphocytes: a comparative study","volume":"159","author":"Gattringer","year":"1981","journal-title":"Immunobiology"},{"key":"2020010903081032400_rrw051C64","first-page":"P53","article-title":"Signal transduction in T cells: an overview","volume":"11","author":"Cogoli-Greuter","year":"2004","journal-title":"J Gravit Physiol"},{"key":"2020010903081032400_rrw051C65","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"Summers","year":"2010","journal-title":"Trends Immunol"},{"key":"2020010903081032400_rrw051C66","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.intimp.2013.11.010","article-title":"Reprint of neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"2020010903081032400_rrw051C67","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1074\/jbc.M406968200","article-title":"Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2","volume":"280","author":"Solovjov","year":"2005","journal-title":"J Biol Chem"},{"key":"2020010903081032400_rrw051C68","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/japplphysiol.00730.2009","article-title":"Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung","volume":"108","author":"Tian","year":"2010","journal-title":"J Appl Physiol"},{"key":"2020010903081032400_rrw051C69","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3357\/ASEM.3959.2014","article-title":"Plasma volume and flight duration effects on post-spaceflight soluble adhesion molecules","volume":"85","author":"Austin","year":"2014","journal-title":"Aviat Space Environ Med"},{"key":"2020010903081032400_rrw051C70","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-5728(02)00313-2","article-title":"The effects of spaceflight on adrenergic receptors and agonists and cell adhesion molecule expression","volume":"132","author":"Mills","year":"2002","journal-title":"J Neuroimmunol"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/57\/5\/477\/31614847\/rrw051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/57\/5\/477\/31614847\/rrw051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T03:10:59Z","timestamp":1578539459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/57\/5\/477\/2594913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,9,30]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rrw051","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,9,1]]}}}