{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:11Z","timestamp":1790352551605,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports,\n              Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research in Innovative Areas and\n              the Japan Society for the Promotion of Science for Young Scientists","award":["26461879"],"award-info":[{"award-number":["26461879"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated with in-room computed tomography\u2013based brachytherapy. Eighty patients with Stage IB1\u2013IVA cervical cancer, who had undergone treatment with combined 3D high-dose rate brachytherapy and conformal radiotherapy between October 2008 and May 2011, were retrospectively analyzed. External beam radiotherapy (50 Gy) with central shielding after 20\u201340 Gy was performed for each patient. Cisplatin-based chemotherapy was administered concurrently to advanced-stage patients aged \u226475 years. Brachytherapy was delivered in four fractions of 6 Gy per week. In-room computed tomography imaging with applicator insertion was performed for treatment planning. Information from physical examinations at diagnosis, and brachytherapy and magnetic resonance imaging at diagnosis and just before the first brachytherapy session, were referred to for contouring of the high-risk clinical target volume. The median follow-up duration was 60 months. The 5-year local control, pelvic progression-free survival and overall survival rates were 94%, 90% and 86%, respectively. No significant differences in 5-year local control rates were observed between Stage I, Stage II and Stage III\u2013IVA patients. Conversely, a significant difference in the 5-year overall survival rate was observed between Stage II and III\u2013IVA patients (97% vs 72%; P\u00a0=\u00a00.006). One patient developed Grade 3 late bladder toxicity. No other Grade 3 or higher late toxicities were reported in the rectum or bladder. In conclusion, excellent local control rates were achieved with minimal late toxicities in the rectum or bladder, irrespective of clinical stage.<\/jats:p>","DOI":"10.1093\/jrr\/rrw121","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T07:05:45Z","timestamp":1480057545000},"page":"543-551","source":"Crossref","is-referenced-by-count":79,"title":["In-room computed tomography\u2013based brachytherapy for uterine cervical cancer:\n          results of a 5-year retrospective study"],"prefix":"10.1093","volume":"58","author":[{"given":"Tatsuya","family":"Ohno","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ei","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Okonogi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"},{"name":"Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Oike","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Wakatsuki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ichi","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"2020010903281662500_rrw121C1","first-page":"1181","article-title":"Clinical evaluation of the MR imaging for\n            radiotherapy of uterine carcinoma","volume":"47","author":"Nakano","year":"1987","journal-title":"Nihon Igaku Hoshasen Gakkai\n            Zasshi"},{"key":"2020010903281662500_rrw121C2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/jrr\/rrv047","article-title":"A questionnaire-based survey on 3D\n            image-guided brachytherapy for cervical cancer in Japan: advances and\n            obstacles","volume":"56","author":"Ohno","year":"2015","journal-title":"J Radiat\n            Res"},{"key":"2020010903281662500_rrw121C3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cncr.20734","article-title":"Long-term results of high-dose rate\n            intracavitary brachytherapy for squamous cell carcinoma of the uterine\n            cervix","volume":"103","author":"Nakano","year":"2005","journal-title":"Cancer"},{"key":"2020010903281662500_rrw121C4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1269\/jrr.10091","article-title":"Intracavitary combined with CT-guided\n            interstitial brachytherapy for locally advanced uterine cervical cancer: introduction of\n            the technique and a case presentation","volume":"52","author":"Wakatsuki","year":"2011","journal-title":"J Radiat\n            Res"},{"key":"2020010903281662500_rrw121C5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.radonc.2004.12.015","article-title":"Recommendations from Gynaecological (GYN)\n            GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning\n            in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and\n            CTV","volume":"74","author":"Haie-Meder","year":"2005","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2005.11.014","article-title":"Recommendations from gynaecological (GYN) GEC\n            ESTRO working group (II): concepts and terms in 3D image-based treatment planning in\n            cervix cancer brachytherapy\u20143D dose volume parameters and aspects of 3D image-based\n            anatomy, radiation physics, radiobiology","volume":"78","author":"P\u00f6tter","year":"2006","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0360-3016(96)80018-6","article-title":"Dose\u2013volume histogram analysis of high dose\n            rate intracavitary brachytherapy for uterine cervix cancer","volume":"35","author":"Terahara","year":"1996","journal-title":"Int\n            J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C8","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/jrr\/rru006","article-title":"Dose\u2013volume histogram parameters of\n            high-dose-rate brachytherapy for Stage I\u2013II cervical cancer (\u22644 cm) arising from a\n            small-sized uterus treated with a point A dose-reduced plan","volume":"55","author":"Nakagawa","year":"2014","journal-title":"J\n            Radiat\n            Res"},{"key":"2020010903281662500_rrw121C9","author":"National Cancer Institute","year":"2003"},{"key":"2020010903281662500_rrw121C10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijrobp.2010.10.030","article-title":"International brachytherapy practice\n            patterns: a survey of the Gynecologic Cancer Intergroup (GCIG)","volume":"82","author":"Viswanathan","year":"2012","journal-title":"Int J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.clon.2008.12.001","article-title":"Clinical impact of computed tomography\u2013based\n            image-guided brachytherapy for cervix cancer using the tandem-ring applicator\u2014the\n            Addenbrooke's experience","volume":"21","author":"Tan","year":"2009","journal-title":"Clin Oncol (R Coll\n            Radiol)"},{"key":"2020010903281662500_rrw121C12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.radonc.2010.10.002","article-title":"3D CT-based high-dose-rate brachytherapy for\n            cervical cancer: clinical impact on late rectal bleeding and local\n            control","volume":"97","author":"Kang","year":"2010","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.radonc.2011.07.012","article-title":"Clinical outcome of protocol based image\n            (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or\n            without chemotherapy in patients with locally advanced cervical cancer","volume":"100","author":"P\u00f6tter","year":"2011","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.radonc.2012.04.007","article-title":"Impact of 3D image-based PDR brachytherapy on\n            outcome of patients treated for cervix carcinoma in France: results of the French STIC\n            prospective study","volume":"103","author":"Charra-Brunaud","year":"2012","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ygyno.2013.04.018","article-title":"Intermediate-term results of image-guided\n            brachytherapy and high-technology external beam radiotherapy in cervical cancer: Chiang\n            Mai University experience","volume":"130","author":"Tharavichitkul","year":"2013","journal-title":"Gynecol\n            Oncol"},{"key":"2020010903281662500_rrw121C16","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3109\/0284186X.2013.818253","article-title":"MRI-guided adaptive radiotherapy in locally\n            advanced cervical cancer from a Nordic perspective","volume":"52","author":"Lindegaard","year":"2013","journal-title":"Acta\n            Oncol"},{"key":"2020010903281662500_rrw121C17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ijrobp.2014.07.039","article-title":"Cervical gross tumor volume dose predicts\n            local control using magnetic resonance imaging\/diffusion-weighted imaging-guided\n            high-dose-rate and positron emission tomography\/computed tomography-guided intensity\n            modulated radiation therapy","volume":"90","author":"Dyk","year":"2014","journal-title":"Int J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/1471-2407-14-447","article-title":"CT based three dimensional dose\u2013volume\n            evaluations for high-dose rate intracavitary brachytherapy for cervical\n            cancer","volume":"14","author":"Murakami","year":"2014","journal-title":"BMC\n            Cancer"},{"key":"2020010903281662500_rrw121C19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ygyno.2014.08.027","article-title":"Improved survival of patients with cervical\n            cancer treated with image-guided brachytherapy compared with conventional\n            brachytherapy","volume":"135","author":"Rijkmans","year":"2014","journal-title":"Gynecol\n            Oncol"},{"key":"2020010903281662500_rrw121C20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ijrobp.2014.10.053","article-title":"MRI-guided high-dose-rate intracavitary\n            brachytherapy for treatment of cervical cancer: the University of Pittsburgh\n            experience","volume":"91","author":"Gill","year":"2015","journal-title":"Int J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ijrobp.2015.04.043","article-title":"Clinical outcomes of computed\n            tomography\u2013based volumetric brachytherapy planning for cervical cancer","volume":"93","author":"Simpson","year":"2015","journal-title":"Int J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.radonc.2014.11.045","article-title":"Impact of treatment time and dose escalation\n            on local control in locally advanced cervical cancer treated by chemoradiation and\n            image-guided pulsed-dose rate adaptive brachytherapy","volume":"114","author":"Mazeron","year":"2015","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijrobp.2016.04.025","article-title":"Computed tomography\u2013planned high-dose-rate\n            brachytherapy for treating uterine cervical cancer","volume":"96","author":"Zolciak-Siwinska","year":"2016","journal-title":"Int J Radiat\n            Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.radonc.2016.04.016","article-title":"Long term experience with 3D image guided\n            brachytherapy and clinical outcome in cervical cancer patients","volume":"120","author":"Ribeiro","year":"2016","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.radonc.2016.03.011","article-title":"Image guided brachytherapy in locally\n            advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a\n            multicenter cohort study","volume":"120","author":"Sturdza","year":"2016","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.radonc.2007.04.012","article-title":"Clinical impact of MRI assisted dose volume\n            adaptation and dose escalation in brachytherapy of locally advanced cervix\n            cancer","volume":"83","author":"P\u00f6tter","year":"2007","journal-title":"Radiother\n            Oncol"},{"key":"2020010903281662500_rrw121C27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ygyno.2012.04.036","article-title":"Phase II study of concurrent\n            chemoradiotherapy with high-dose-rate intracavitary brachytherapy in patients with\n            locally advanced uterine cervical cancer: efficacy and toxicity of a low cumulative\n            radiation dose schedule","volume":"126","author":"Toita","year":"2012","journal-title":"Gynecol\n            Oncol"},{"key":"2020010903281662500_rrw121C28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1269\/jrr.09118","article-title":"CT-based 3D dose\u2013volume parameter of the\n            rectum and late rectal complication in patients with cervical cancer treated with\n            high-dose-rate intracavitary brachytherapy","volume":"51","author":"Kato","year":"2010","journal-title":"J Radiat\n            Res"},{"key":"2020010903281662500_rrw121C29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.ijrobp.2009.05.030","article-title":"Rectal dose and source strength of the\n            high-dose-rate iridium-192 both affect late rectal bleeding after intracavitary\n            radiation therapy for uterine cervical carcinoma","volume":"77","author":"Isohashi","year":"2010","journal-title":"Int J Radiat\n            Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.brachy.2016.06.006","article-title":"Dose\u2013volume histogram analysis of composite\n            EQD2 dose distributions using the central shielding technique in cervical cancer\n            radiotherapy","volume":"15","author":"Tamaki","year":"2016","journal-title":"Brachytherapy"},{"key":"2020010903281662500_rrw121C31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijrobp.2006.12.021","article-title":"Computed tomography versus magnetic resonance\n            imaging\u2013based contouring in cervical cancer brachytherapy: results of a prospective\n            trial and preliminary guidelines for standardized contours","volume":"68","author":"Viswanathan","year":"2007","journal-title":"Int\n            J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C32","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3109\/0284186X.2013.813068","article-title":"High-risk clinical target volume delineation\n            in CT-guided cervical cancer brachytherapy: impact of information from FIGO stage with\n            or without systematic inclusion of 3D documentation of clinical gynecological\n            examination","volume":"52","author":"Hegazy","year":"2013","journal-title":"Acta\n            Oncol"},{"key":"2020010903281662500_rrw121C33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ijrobp.2015.09.023","article-title":"Value of magnetic resonance imaging without\n            or with applicator in place for target definition in cervix cancer\n            brachytherapy","volume":"94","author":"P\u00f6tter","year":"2016","journal-title":"Int J Radiat Oncol Biol\n            Phys"},{"key":"2020010903281662500_rrw121C34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brachy.2015.09.002","article-title":"Hybrid (CT\/MRI based) vs. MRI only based\n            image-guided brachytherapy in cervical cancer: dosimetry comparisons and clinical\n            outcome","volume":"15","author":"Choong","year":"2016","journal-title":"Brachytherapy"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/58\/4\/543\/31607283\/rrw121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/58\/4\/543\/31607283\/rrw121.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T03:34:25Z","timestamp":1578540865000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/58\/4\/543\/2703142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,12,16]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rrw121","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2016,12,16]]}}}