{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:50:19Z","timestamp":1784299819949,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004083","name":"Ministry of Science, ICT & Future Planning","doi-asserted-by":"publisher","award":["NRF-2016M3A9C6918275"],"award-info":[{"award-number":["NRF-2016M3A9C6918275"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Mobile EMF consortium"},{"name":"Graduate School of YONSEI University Research Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disease leading to progressive loss of memory and other cognitive functions. One of the well-known pathological markers of AD is the accumulation of amyloid-beta protein (A\u03b2), and its plaques, in the brain. Recent studies using Tg-5XFAD mice as a model of AD have reported that exposure to radiofrequency electromagnetic fields (RF-EMF) from cellular phones reduced A\u03b2 plaques in the brain and showed beneficial effects on AD. In this study, we examined whether exposure to 1950 MHz RF-EMF affects A\u03b2 processing in neural cells. We exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to RF-EMF (SAR 6 W\/kg) for 2 h per day for 3 days, and analyzed the mRNA and protein expression of the key genes related to A\u03b2 processing. When exposed to RF-EMF, mRNA levels of APP, BACE1, ADAM10 and PSEN1 were decreased in HT22, but the mRNA level of APP was not changed in SH-SY5Y cells. The protein expression of APP and BACE1, as well as the secreted A\u03b2 peptide, was not significantly different between RF-EMF\u2013exposed 7w-PSML, HT22 and SH-SY5Y cells and the unexposed controls. These observations suggest that RF-EMF exposure may not have a significant physiological effect on A\u03b2 processing of neural cells in the short term. However, considering that we only exposed HT22 and SH-SY5Y cells to RF-EMF for 2 h per day for 3 days, we cannot exclude the possibility that 1950 MHz RF-EMF induces physiological change in A\u03b2 processing with long-term and continuous exposure.<\/jats:p>","DOI":"10.1093\/jrr\/rrx045","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T11:07:09Z","timestamp":1506942429000},"page":"18-26","source":"Crossref","is-referenced-by-count":20,"title":["Effects of 1950 MHz radiofrequency electromagnetic fields on A\u03b2 processing in human neuroblastoma and mouse hippocampal neuronal cells"],"prefix":"10.1093","volume":"59","author":[{"given":"Jeongyeon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hwa","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of EMF Research Team, Radio and Broadcasting Technology Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejon, 305-700, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Electrical and Computer Engineering, Chungbuk National University, Cheongju, Chungbuk, 362-763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of 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