{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:48:56Z","timestamp":1776930536045,"version":"3.51.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81771921"],"award-info":[{"award-number":["81771921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy\/chemoradiotherapy (28 cases), surgery (9 cases), palliative radiotherapy and\/or chemotherapy (17 cases), or supportive care (7 cases). The median radiotherapy doses for EC and HPC in the radiotherapy\/chemoradiotherapy group were 64.5 Gy (range, 0\u201370) and 70 Gy (range, 60\u201375.2), respectively. Seven patients in the surgery group received pharyngoesophagectomy with gastric pull-up reconstruction, and two received esophagectomy followed by radiotherapy at the hypopharynx. Cox proportional hazard analysis revealed that the outcome of active treatments, including surgery and radiotherapy\/chemoradiotherapy, was better than that of conservative care. In survival analysis, patients in the surgery group tended to have a better 3-year overall survival rate than those in the radiotherapy\/chemoradiotherapy group (55.6% vs 30.9%); however, this difference was not statistically different (P = 0.493). The two groups had similar 3-year progression-free survival rates (30.6% and 33.3%, P = 0.420). The current study suggested that radiotherapy\/chemoradiotherapy should be considered as an important treatment modality in addition to surgery for synchronous HPC and EC.<\/jats:p>","DOI":"10.1093\/jrr\/rrz042","type":"journal-article","created":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T15:06:48Z","timestamp":1558883208000},"page":"658-665","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes for 61 cases of hypopharyngeal cancer with synchronous esophageal cancer"],"prefix":"10.1093","volume":"60","author":[{"given":"Shixuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Oncology, Affiliated Hospital of Southwest Medical University, No. 25, Taiping street, Luzhou city, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Affiliated Hospital of Southwest Medical University, No. 25, Taiping street, Luzhou city, Sichuan, China"},{"name":"Department of Oncology, People\u2019s Hospital of Cangxi County, Guangyuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baisen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Head Neck Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head Neck Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic 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Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shichuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Affiliated Hospital of Southwest Medical University, No. 25, Taiping street, Luzhou city, Sichuan, China"},{"name":"Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"2019110512361275700_rrz042C1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-2168.2001.01696.x","article-title":"Other primary cancers occurring after treatment of superficial oesophageal cancer","volume":"88","author":"Kokawa","year":"2001","journal-title":"Br J 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