{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:52:10Z","timestamp":1765486330730,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP04J11896"],"award-info":[{"award-number":["JP04J11896"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Emerging\/Re-emerging Infectious Diseases"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17fk0108111h8001"],"award-info":[{"award-number":["17fk0108111h8001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adult T-cell leukemia is one of the life-threatening diseases that occur in individuals infected with human T-cell leukemia virus type 1 (HTLV-1). Clinical trials of hematopoietic stem cell transplantation therapy are being performed in addition to chemotherapy; however, neither is satisfactory. As a pretreatment for transplantation, anticancer drugs or whole-body irradiation is used to decrease the number of HTLV-1-infected cells, but there are numerous side effects. Therefore, in the present study, using a mouse model of HTLV-1 infection, the long-term survival and number of infected cells in the reservoir organ were investigated in order to determine the effect of \u03b3-irradiation on HTLV-1-infected mice in vivo. There was no improvement in the survival period following \u03b3-irradiation in the \u03b3-irradiated group after HTLV-1 infection when compared with the HTLV-1-infected group. It was also found that the incidence of splenomegaly was \u226580% in the HTLV-1-infected and \u03b3-irradiated group, which was significantly higher than that in the HTLV-1-infected mice. The tissue morphology in the spleen became non-uniform because of \u03b3-rays. Importantly, the number of infected cells in the spleen was increased 4.1-fold in the HTLV-1-infected and \u03b3-irradiated mice compared with that in the HTLV-1-infected mice. Careful consideration might be necessary when using whole-body irradiation in patients with HTLV-1 infection.<\/jats:p>","DOI":"10.1093\/jrr\/rrz050","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T14:00:23Z","timestamp":1561471223000},"page":"705-708","source":"Crossref","is-referenced-by-count":2,"title":["Effects of radiation based on whole-body irradiation in HTLV-1-infected mice"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-385X","authenticated-orcid":false,"given":"Masakazu","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Microbiology, Kansai Medical University, Hirakata, Osaka, Japan"},{"name":"Faculty of Bioscience, Nagahama Institute of Bioscience and Technology, 1266 Tamura, Nagahama, Shiga, Japan"},{"name":"Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kawazu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kansai Medical University, Hirakata, Osaka, Japan"},{"name":"Faculty of Bioscience, Nagahama Institute of Bioscience and Technology, 1266 Tamura, Nagahama, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kansai Medical University, Hirakata, Osaka, Japan"},{"name":"Faculty of Bioscience, Nagahama Institute of Bioscience and Technology, 1266 Tamura, Nagahama, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Takenouchi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kansai Medical University, Hirakata, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Miwa","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience, Nagahama Institute of Bioscience and Technology, 1266 Tamura, Nagahama, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"2020082609471216300_rrz050C1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama","year":"1977","journal-title":"Blood"},{"key":"2020082609471216300_rrz050C2","first-page":"129","article-title":"Epidemiology of HTLV-I\/II in Japan 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