{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:34:11Z","timestamp":1790184851426,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["16\u00a0K08970"],"award-info":[{"award-number":["16\u00a0K08970"]}]},{"name":"Grant-in-Aid for Young Scientists","award":["15\u00a0K19804"],"award-info":[{"award-number":["15\u00a0K19804"]}]},{"DOI":"10.13039\/501100001700","name":"Japanese Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumulative increase in the frequency of Dics and chromosome translocations (Trs) formation could be observed during three consecutive CT examinations performed over the course of 3\u20134\u00a0years, using lymphocytes in peripheral bloods of eight patients (five males and three females; age range 27\u201377\u00a0years; mean age, 64\u00a0years). The effective radiation dose per CT examination estimated from the computational dosimetry system was 22.0\u201373.5\u00a0mSv, and the average dose per case was 40.5\u00a0mSv. The frequency of Dics formation significantly increased after a CT examination and tended to decrease before the next examination. Unlike Dics analysis, we found no significant increase in the frequency of Trs formation before and after the CT examination, and we observed no tendency for the frequency to decrease before the next CT examination. The frequency of Trs formation was higher than that of Dics formation regardless of CT examination. Furthermore, neither analysis of Dics nor Trs showed a cumulative increase in the frequency of formation following three consecutive CT examinations.<\/jats:p>","DOI":"10.1093\/jrr\/rrz068","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T20:21:40Z","timestamp":1567282900000},"page":"729-739","source":"Crossref","is-referenced-by-count":15,"title":["Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients"],"prefix":"10.1093","volume":"60","author":[{"given":"Yu","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyoshi","family":"Noji","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomisato","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Sugai","sequence":"first","affiliation":[{"name":"Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kurosu","sequence":"first","affiliation":[{"name":"Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Ujiie","sequence":"first","affiliation":[{"name":"Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Tsuyama","sequence":"first","affiliation":[{"name":"Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Yanagi","sequence":"first","affiliation":[{"name":"Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Yanai","sequence":"first","affiliation":[{"name":"Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ohba","sequence":"first","affiliation":[{"name":"Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Radiation Physics and Chemistry, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kamiya","sequence":"first","affiliation":[{"name":"Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki A","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Radiation Biology, Institute of Radiation Emergency Medicine, Hirosaki University, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akia","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"2020070104241246700_ref1","first-page":"339","volume-title":"Report (Scientific Annex B, Exposures of the public and workers from various source of radiation) vol I","author":"United Nations Scientific Committee on the Effects of Atomic Radiation. 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