{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:52:18Z","timestamp":1790797938815,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesorectum motion and dosimetric changes. Fourteen patients treated with NA-CRT for rectal cancer between 2014 and 2016 were included in the analysis. The mesorectum and clinical target volume (CTV) were delineated on planning computed tomography (CT) and cone-beam CT (CB-CT) scans. After planning with a volumetric modulated arc therapy (VMAT) plan, re-planning was performed on all CB-CTs. Finally, the volumetric and dosimetric changes of PTV and mesorectum were evaluated in all CB-CTs compared with the initial CT and VMAT plans. The geometrical center of mesorectum volume in CB-CTs had moved 1 (0.2\u20136.6), 1.6 (0.2\u20133.8) and 1.6 (0\u20134.9) mm in the x, y and z-axis respectively compared with the initial CT. The dosimetric parameters of PTV including D2, D95 and D98 on CB-CT showed a median 47.19 (46.70\u201347.80), 45.05 (44.18\u201345.68) and 44.69 (43.83\u201345.48) Gy and median 1% (1\u20132), 0% (0\u20132) and 1% (0\u20132) dosimetric change compared with the initial VMAT plan. In our study, we have shown that the mesorectum has moved up to 20\u00a0mm in the lateral and anterior\u2013posterior direction and almost 10\u00a0mm in the superior\/inferior direction during RT, causing a median of ~2% change in dosimetric parameters. Therefore, these movements must be considered in determining PTV margins to avoid dosimetric changes.<\/jats:p>","DOI":"10.1093\/jrr\/rrz092","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T12:11:43Z","timestamp":1576584703000},"page":"335-342","source":"Crossref","is-referenced-by-count":13,"title":["The importance of mesorectum motion in determining PTV margins in rectal cancer patients treated with neoadjuvant radiotherapy"],"prefix":"10.1093","volume":"61","author":[{"given":"Zumre Arican","family":"Alickikus","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, \u0130zmir 35340, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kuru","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, \u0130zmir 35340, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbaros","family":"Aydin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, \u0130zmir 35340, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dogukan","family":"Akcay","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, \u0130zmir 35340, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur Bilkay","family":"Gorken","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, \u0130zmir 35340, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"2020052418595015000_ref1","article-title":"SEER cancer statistics review, 1975-2013, National Cancer Institute 2016","author":"Howlader"},{"key":"2020052418595015000_ref2","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0140-6736(86)91510-2","article-title":"Recurrence and survival after total mesorectal excision for rectal cancer","volume":"1","author":"Heald","year":"1986","journal-title":"Lancet"},{"key":"2020052418595015000_ref3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1748-717X-8-114","article-title":"Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy","volume":"6","author":"Yeo","year":"2013","journal-title":"Radiat Oncol"},{"issue":"6","key":"2020052418595015000_ref4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jso.23198","article-title":"Failure patterns correlate with the tumor response after preoperative chemoradiotherapy for locally advanced rectal cancer","volume":"106","author":"Lim","year":"2012","journal-title":"J Surg Oncol"},{"key":"2020052418595015000_ref5","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/bjs.5141","article-title":"Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analysis of micrometastases","volume":"92","author":"Matsumoto","year":"2005","journal-title":"Br J Surg"},{"key":"2020052418595015000_ref6","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s10350-006-0714-z","article-title":"Indication and benefit of pelvic sidewall dissection for rectal cancer","volume":"49","author":"Sugihara","year":"2006","journal-title":"Dis Colon Rectum"},{"issue":"5","key":"2020052418595015000_ref7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/ijc.30805","article-title":"What has preoperative radio(chemo)therapy brought to localized rectal cancer patients in terms of perioperative and long-term outcomes over the past decades? 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