{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:05:32Z","timestamp":1753877132966,"version":"3.41.2"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5T32HL007149-47"],"award-info":[{"award-number":["5T32HL007149-47"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High-risk SCD may be managed with chronic red blood cell exchange transfusions. We examined the prevalence of sleep-associated hypoxemia (\u22655 minutes at SpO2 \u226488%) or nocturnal Hb desaturation (NHD) in chronically transfused adults with SCD. Of 41 identified participants, 15 (36.6%) had tested positive for NHD at some point prior to enrollment. The median duration of desaturation (SpO2 \u226488%) in those that tested positive was 88.3 minutes (IQR 27.9-226.0 minutes). Participants with and without NHD were compared using non-parametric statistical tests. Compared to participants without NHD, those with NHD had higher absolute reticulocyte counts (P\u2009=\u2009.018) and white blood counts (P\u2009=\u2009.05) and tended to be older. They had more anemia (P\u2009=\u2009.11) and higher lactate dehydrogenase levels (P\u2009=\u2009.072). Older age at initiation of chronic red blood cell transfusions associated the strongest with a longer duration of NHD (\u03c1\u2009=\u20090.4253, P\u2009=\u2009.0067), while prior history of cerebrovascular events associated with a shorter duration of NHD (P\u2009=\u2009.0315). Our results demonstrate that NHD is common in adults being treated with red blood cell exchange for high-risk SCD and associates with laboratory evidence of increased disease activity. Increased awareness of this complication and appropriate screening may provide an additional simple, low-cost, and physiologically relevant treatment intervention, that is oxygen therapy.<\/jats:p>","DOI":"10.1093\/jscdis\/yoaf003","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T18:31:52Z","timestamp":1738348312000},"source":"Crossref","is-referenced-by-count":0,"title":["Nocturnal hemoglobin desaturation in chronically transfused adults with sickle cell disease: a retrospective study"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-942X","authenticated-orcid":false,"given":"Mofiyin A","family":"Obadina","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, University of North Carolina , Chapel Hill, NC 27514,","place":["United 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