{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:31Z","timestamp":1753877191778,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Upper tract urothelial carcinoma (UTUC) is a rare genitourinary entity of the renal pelvis and the ureter characterized by an aggressive behavior. Cisplatin-based chemotherapy is the first-line therapy of metastatic UTUC. However, a large number of patients with metastatic UTUC are considered ineligible for cisplatin. Immunotherapy emerged as a promising treatment in this setting. Brain metastasis from UTUC is unusual, occurring most often in the presence of systemic metastases. Local therapies such as stereotactic radiosurgery, neurosurgical resection and whole-brain radiotherapy (WBRT) remain the main therapeutic options for brain metastasis. We report a case of a 65-year-old male patient presenting with generalized tonic\u2013clonic seizure. Imaging studies confirmed the presence of multiple brain metastasis. During an evaluation for the primary, he was found to be having metastatic UTUC of the renal pelvis. The brain metastases were treated by hippocampal sparing WBRT with minimal neurotoxicity. The primary tumor was treated by pembrolizumab.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa126","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T19:12:14Z","timestamp":1586805134000},"source":"Crossref","is-referenced-by-count":0,"title":["Seizure as the first manifestation of transitional cell carcinoma of the renal pelvis"],"prefix":"10.1093","volume":"2020","author":[{"given":"Mohamad","family":"Moussa","sequence":"first","affiliation":[{"name":"Head of Urology Department, Zahraa Hospital, University Medical Center, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abou","family":"Chakra","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baraa","family":"Dabboucy","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios G","family":"Papatsoris","sequence":"first","affiliation":[{"name":"2nd Department of Urology, School of Medicine, Sismanoglio Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Fares","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"2020071609525169200_ref1","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.18632\/oncotarget.12239","article-title":"Perioperative treatments for resected upper tract urothelial carcinoma: a network 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single brain metastasis: factors impacting control","volume":"3","author":"Wagner","year":"2014","journal-title":"J Radiosurg SBRT"},{"key":"2020071609525169200_ref9","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.4103\/2152-7806.111297","article-title":"Surgery for brain metastases","volume":"4","author":"Yaeger","year":"2013","journal-title":"Surg Neurol Int"},{"key":"2020071609525169200_ref10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s11255-006-9155-9","article-title":"An unusual case of transitional cell carcinoma of renal pelvis presenting with brain metastases","volume":"39","author":"Kolla","year":"2007","journal-title":"Int Urol Nephrol"}],"container-title":["Journal of Surgical Case 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