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This is a case report of a 48-year-old male with CRLM being treated with HAIPC, who presents with recurrent pleural effusions found to be benign\/transudative after right-side video-assisted thoracoscopic surgery. Discussion: This study suggests that HAIPC causes recurrent sympathetic pleural effusions as a side effect of the perihepatic inflammation of the localized chemotherapy treatment. Furthermore, we question if sympathetic pleural effusions are a prelude to hepatic toxicity from HAIPC. Lastly, this paper aims to guide the differential diagnosis of pleural effusions in the cancer patient being treated with HAIPC.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa137","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T11:08:48Z","timestamp":1587380928000},"source":"Crossref","is-referenced-by-count":1,"title":["Do hepatic artery infusion pumps cause recurrent pleural effusions?"],"prefix":"10.1093","volume":"2020","author":[{"given":"Emily Ann","family":"Harris","sequence":"first","affiliation":[{"name":"Amita Saint Joseph Hospital, 2900 N Lakeshore Drive, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Rafael Garza","family":"Castillon","sequence":"additional","affiliation":[{"name":"Amita Saint Joseph Hospital, 2900 N Lakeshore Drive, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Bhakta","sequence":"additional","affiliation":[{"name":"Amita Saint Joseph Hospital, 2900 N Lakeshore Drive, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"2020082405072807200_ref1","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.3747\/co.21.1577","article-title":"Hepatic arterial infusion pump chemotherapy in the management of colorectal liver metastases: expert consensus statement","volume":"21","author":"Karanicolas","year":"2014","journal-title":"Curr Oncol"},{"key":"2020082405072807200_ref2","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.3747\/co.21.1592","article-title":"Hepatic arterial infusion pump chemotherapy for colorectal liver metastases: an old technology in a new era","volume":"21","author":"Ko","year":"2014","journal-title":"Curr Oncol"},{"key":"2020082405072807200_ref3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2217\/hep.15.9","article-title":"Hepatic arterial infusional chemotherapy in the management of colorectal cancer liver metastases","volume":"2","author":"Doussot","year":"2015","journal-title":"Hepat Oncol"},{"key":"2020082405072807200_ref4","first-page":"2223","article-title":"Special considerations in interpreting liver function tests","volume":"59","author":"Johnston","year":"1999","journal-title":"Am Fam Physician"},{"key":"2020082405072807200_ref5","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1245\/s10434-011-2102-8","article-title":"Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors","volume":"19","author":"Ito","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"2020082405072807200_ref6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.22906","article-title":"Primary biliary cirrhosis","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/8\/rjaa137\/33677141\/rjaa137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/8\/rjaa137\/33677141\/rjaa137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T09:07:42Z","timestamp":1598260062000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaa137\/5857475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaa137","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,8,1]]},"article-number":"rjaa137"}}