{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:23:00Z","timestamp":1791901380210,"version":"4.3.4"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bevacizumab has been used as an effective drug for ovarian cancer. However, serious adverse effects, such as gastrointestinal perforation, can occur. Spontaneous gastrointestinal perforation is an uncommon, yet life-threatening complication related to bevacizumab administration. We present the case of a 65-year-old Caucasian female who presented with acute abdomen 10\u00a0days after the first administration of bevacizumab for ovarian cancer treatment, and she was diagnosed intraoperatively with a massive duodenal perforation. Bowel perforation after bevacizumab administration is a serious and potentially lethal complication. Careful follow-up of the patients is necessary in order to detect any signs of this condition in time.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa174","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T11:08:15Z","timestamp":1590491295000},"source":"Crossref","is-referenced-by-count":4,"title":["Spontaneous massive duodenal perforation after ovarian cancer treatment with bevacizumab"],"prefix":"10.1093","volume":"2020","author":[{"given":"Michael","family":"Karanikas","sequence":"first","affiliation":[{"name":"1st Department of Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinia","family":"Kofina","sequence":"first","affiliation":[{"name":"1st Department of Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Potolidis","sequence":"first","affiliation":[{"name":"1st Department of Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soultana","family":"Foutzitzi","sequence":"first","affiliation":[{"name":"Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savas","family":"Deftereos","sequence":"first","affiliation":[{"name":"Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Effraemidou","sequence":"first","affiliation":[{"name":"1st Department of Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Lyratzopoulos","sequence":"first","affiliation":[{"name":"1st Department of Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"2020061822132545800_ref1","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.3802\/jgo.2016.27.e47","article-title":"Bevacizumab toxicity in heavily preatreated recurrent epithelial ovarian, fallopian tube and primary peritoneal cancers","volume":"27","author":"Martin","year":"2016","journal-title":"J Gynecol Oncol"},{"key":"2020061822132545800_ref2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/healthcare7030109","article-title":"A new therapeutic strategy for recurrent ovarian cancer \u2013 bevacizumab 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