{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:07:49Z","timestamp":1768450069578,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Proliferative lesions of the Brunner\u2019s glands are uncommonly encountered lesions of the small intestine, originating from the deeply seated mucosal and submucosal Brunner\u2019s glands, mainly in the duodenum. The vast majorities of these lesions are benign and include Brunner\u2019s glands hyperplasia (adenomas\/nodules) and hamartomas. The etiology and pathogenesis of these lesions are not fully understood, and the diagnosis can sometimes be challenging. We report a case of Brunner\u2019s gland hamartoma in a 57-year-old man who presented with chronic dyspepsia, hematemesis and weight loss. Endoscopic and radiological investigations show a submucosal polypoid lesion at the first part of the duodenum. Routine endoscopic biopsies demonstrated normal duodenal mucosa. The lesion considered endoscopically unresectable and was surgically resected. Frozen section examination and intraoperative consultation showed unremarkable duodenal mucosa and histologically bland Brunner\u2019s glands.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa191","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T11:09:13Z","timestamp":1594292953000},"source":"Crossref","is-referenced-by-count":5,"title":["Brunner\u2019s glands hamartoma with pylorus obstruction: a case report and review of literature"],"prefix":"10.1093","volume":"2020","author":[{"given":"Mohammed A","family":"Bakir","sequence":"first","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Y","family":"AlYousef","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad I","family":"Alsohaibani","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled O","family":"Alsaad","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"2020082614170609500_ref1","first-page":"73","article-title":"Hamartoma of Brunner's gland causing partial obstruction of the ileum","volume":"34","author":"Henken","year":"1983","journal-title":"J Can Assoc Radiol"},{"key":"2020082614170609500_ref2","first-page":"246","article-title":"Hyperplasia of Brunner's glands of the duodenum","volume":"43","author":"Fuller","year":"1997","journal-title":"Am Surg"},{"key":"2020082614170609500_ref3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s40792-019-0732-4","article-title":"Adenocarcinoma of the duodenum arising from Brunner's gland resected by partial duodenectomy: a case report","volume":"5","author":"Mochizuki","year":"2019","journal-title":"Surg Case Rep"},{"key":"2020082614170609500_ref4","doi-asserted-by":"crossref","first-page":"6340565","DOI":"10.1155\/2019\/6340565","article-title":"Brunner's gland hyperplasias and hamartomas in association with helicobacter pylori","volume":"2019","author":"Destek","year":"2019","journal-title":"Can J Gastroenterol Hepatol"},{"key":"2020082614170609500_ref5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12876-019-1074-1","article-title":"A giant Brunner's gland hamartoma being treated as a pedunculated polyp: a case report","volume":"19","author":"Yi","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"2020082614170609500_ref6","first-page":"290","article-title":"Brunner's gland hamartomas: clinical presentation and pathological features of 27 cases","volume":"90","author":"Levine","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2020082614170609500_ref7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02256458","article-title":"Duodenal intussusception secondary to Brunner's gland hamartoma. A case report","volume":"2","author":"Rieth","year":"1977","journal-title":"Gastrointest Radiol"},{"key":"2020082614170609500_ref8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0016-5107(98)70228-7","article-title":"Endoscopic injection and polypectomy for bleeding Brunner's gland hamartoma: case report and expanded literature review","volume":"47","author":"Walden","year":"1998","journal-title":"Gastrointest Endosc"},{"key":"2020082614170609500_ref9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4103\/IJPM.IJPM_69_18","article-title":"Brunner's gland hamartoma with dysplasia, presenting as multiple duodenal polyps: an unexplored entity with literature review","volume":"62","author":"Rath","year":"2019","journal-title":"Indian J Pathol Microbiol"},{"key":"2020082614170609500_ref10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1055\/s-2007-1018373","article-title":"Endoscopic removal of a large ulcerated Brunner's gland adenoma","volume":"18","author":"Khawaja","year":"1986","journal-title":"Endoscopy"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/8\/rjaa191\/33683434\/rjaa191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/8\/rjaa191\/33683434\/rjaa191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T18:17:18Z","timestamp":1598465838000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaa191\/5897272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaa191","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,8,1]]},"article-number":"rjaa191"}}