{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:57:45Z","timestamp":1791979065901,"version":"4.4.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant paratesticular and spermatic cord tumors are rare and often misdiagnosed preoperatively due to clinical presentations similar to other benign scrotal mass etiologies. Only a few cases regarding giant, paratesticular liposarcomas (&amp;gt;10\u00a0cm) have been reported. We report a unique case of an aggressive giant dedifferentiated liposarcoma of the scrotum with osteosarcoma features in a 70-year-old patient who initially presented with indolent scrotal swelling. A CT scan showed a large, complex, solid and cystic mass (12.0 x 15.5 x 19.0\u00a0cm) in the right scrotum. With a concern of a complex hydrocele, the patient was taken to the operating room for a scrotal approach to excise the hydrocele, but the spermatic cord was not traced to any discernible testicle as the entire mass was indurated and multilocular, and was excised. Pathology revealed a dedifferentiated liposarcoma, with MDM2 amplification. The patient\u2019s course was complicated due to metastatic disease.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa342","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:16:03Z","timestamp":1596194163000},"source":"Crossref","is-referenced-by-count":5,"title":["Dedifferentiated liposarcoma of the scrotum. Case report and literature review"],"prefix":"10.1093","volume":"2020","author":[{"given":"Ruben D","family":"Salas-Parra","sequence":"first","affiliation":[{"name":"Department of Surgery, Bronxcare Health System, Bronx, NY 10457, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa L","family":"Tavares","sequence":"additional","affiliation":[{"name":"St. George\u2019s University School of Medicine, St. George, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-6325","authenticated-orcid":false,"given":"Ranjan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bronxcare Health System, Bronx, NY 10457, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Silletti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology, Bronxcare Health System. Bronx, NY 10457, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bronxcare Health System, Bronx, NY 10457, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"2020091709141533000_ref1","article-title":"Rare case of a well-differentiated Paratesticular sarcoma of the spermatic cord in a 60-year-old patient","volume":"2017","author":"Benna","year":"2017","journal-title":"Case Rep Urol."},{"key":"2020091709141533000_ref2","first-page":"613","article-title":"Giant paratesticular liposarcoma: a case report and review of the literature","volume":"8","author":"Li","year":"2018","journal-title":"Molecular and Clinical Oncology"},{"key":"2020091709141533000_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/shorts.2011.011064","article-title":"Scrotal Liposarcoma - a rare Extratesticular tumour","volume":"2","author":"Patel","year":"2011","journal-title":"JRSM Short Reports"},{"key":"2020091709141533000_ref4","first-page":"19","article-title":"Primary spermatic cord tumours: disease characteristics, prognostic factors, and treatment outcomes","volume":"32","author":"Rodriguez","year":"2014","journal-title":"Uro Oncol"},{"key":"2020091709141533000_ref5","volume-title":"WHO Classification of Soft Tissue Tumors","author":"Fletcher","year":"2013"},{"key":"2020091709141533000_ref6","doi-asserted-by":"crossref","DOI":"10.1007\/s11864-020-0705-7","article-title":"Dedifferentiated Liposarcoma: systemic therapy options","volume":"21","author":"Gahvari","year":"2020","journal-title":"Curr Treat Options Oncol."},{"key":"2020091709141533000_ref7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.eucr.2018.01.022","article-title":"Liposarcoma of the spermatic cord associated with scrotum lipoma: a case report and review of the literature","volume":"17","author":"Yamamichi","year":"2018","journal-title":"Urol Case Rep."},{"key":"2020091709141533000_ref8","doi-asserted-by":"crossref","first-page":"E316","DOI":"10.5489\/cuaj.3346","article-title":"Multidisciplinary approach to giant paratesticular liposarcoma","volume":"10","author":"Sope\u00f1a-Sutil","year":"2016","journal-title":"Can Urol Assoc J"},{"key":"2020091709141533000_ref9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/iju.13345","article-title":"Adult genitourinary sarcoma: clinical characteristics and survival in a series of patients treated at a high-volume institution","volume":"24","author":"Wang","year":"2017","journal-title":"Int J Urol."}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/9\/rjaa342\/33754998\/rjaa342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/9\/rjaa342\/33754998\/rjaa342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T13:17:02Z","timestamp":1600348622000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaa342\/5905431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaa342","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,9,1]]},"article-number":"rjaa342"}}