{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:32:12Z","timestamp":1789176732971,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A jejunal gastrointestinal stromal tumour (GIST) is a rare neoplasm of the gastrointestinal tract. Massive bleeding due to a jejunal GIST is a diagnostic challenge and could present as a life-threatening situation needing urgent intervention. A 54-year-old woman presented with episodes of melaena and haematochezia for the previous 3\u00a0days. An oesophagoduodenoscopy was inconclusive. A contrast computed tomography (CT) scan showed a well-defined extraluminal mass in the proximal jejunum suggestive of a bleeding GIST. Her haemodynamic state deteriorated despite initial supportive therapy including a blood transfusion. An urgent laparotomy to excise the jejunal mass was performed. Histopathology and immunohistochemical studies confirmed the diagnosis. She subsequently received adjuvant imatinib therapy. She has remained symptom free at 5\u00a0months post-op. We therefore present a rare case of obscure massive gastrointestinal bleeding due to a jejunal GIST. The CT scan was the most effective investigation to detect the source of bleeding in this case.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa355","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T11:55:38Z","timestamp":1596714938000},"source":"Crossref","is-referenced-by-count":11,"title":["Massive bleeding of a jejunal gastrointestinal stromal tumour: a rare case of a life-threatening presentation"],"prefix":"10.1093","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-6101","authenticated-orcid":false,"given":"Schauki","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of General Surgery, Albassel Hospital, Tartous, Syrian Arab Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Albassel Hospital, Tartous, Syrian Arab Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"2020110301210180900_ref1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.radcr.2019.05.015","article-title":"Multifocal gastrointestinal stromal tumor: a case report with CT, surgical, and histopathologic correlation","volume":"14","author":"Brogna","year":"2019","journal-title":"Radiol Case Rep"},{"key":"2020110301210180900_ref2","first-page":"1","article-title":"A rare case report of locally recurrent hemorrhagic duodenal gastrointestinal stromal tumor: therapeutic challenges and review of prognostic indicators for recurrence","volume":"1","author":"Mahmoud","year":"2020","journal-title":"J Surg Case Rep"},{"key":"2020110301210180900_ref3","doi-asserted-by":"publisher","DOI":"10.31487\/j.SCR.2019.06.04","article-title":"A rare case of life-threatening bleeding caused by a Jejunal GIST","author":"Liyanage","year":"2019","journal-title":"Surg Case Rep"},{"key":"2020110301210180900_ref4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijscr.2019.06.053","article-title":"Jejunal GIST: hunting down an unusual cause of gastrointestinal bleed using double balloon enteroscopy. A case report","volume":"60","author":"Dualim","year":"2019","journal-title":"Int J Surg Case Rep"},{"key":"2020110301210180900_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejrnm.2011.01.006","article-title":"Multislice CT imaging of gastrointestinal stromal tumors (GISTs)","volume":"42","author":"Abdel-Monem","year":"2011","journal-title":"Egypt J Radiol Nuclear Med"},{"key":"2020110301210180900_ref6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yasu.2014.05.014","article-title":"Ronald P. DeMatteo. GIST tumors: who should get imatinib and for how long?","volume":"48","author":"Balachandran","year":"2014","journal-title":"Adv Surg"},{"key":"2020110301210180900_ref7","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2147\/CMAR.S159689","article-title":"Management of hemorrhage in gastrointestinal stromal tumors: a review","volume":"10","author":"Liu","year":"2018","journal-title":"Cancer Manag Res"},{"key":"2020110301210180900_ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7152406","article-title":"Gastrointestinal bleeding is an independent risk factor for poor prognosis in GIST patients","author":"Liu","year":"2017","journal-title":"Biomed Res Int"},{"key":"2020110301210180900_ref9","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1158\/1078-0432.CCR-12-0625","article-title":"Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with Imatinib-resistant gastrointestinal stromal Tumors","volume":"18","author":"Heinrich","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2020110301210180900_ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10120-015-0526-8","article-title":"The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines","volume":"19","author":"Nishida","year":"2016","journal-title":"Gastric Cancer"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/10\/rjaa355\/34106538\/rjaa355.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/10\/rjaa355\/34106538\/rjaa355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T06:21:10Z","timestamp":1604384470000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaa355\/5918936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaa355","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,10,1]]},"article-number":"rjaa355"}}