{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:25:39Z","timestamp":1771511139274,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glucocorticoids are commonly used in the management of patients with brain Tumour for reducing peritumoral and vasogenic edema. However, they may lead to development of limb and life-threatening conditions such as necrotizing fasciitis (NF). NF is a rare but potentially lethal condition. Early detection and aggressive treatment may lead to decreased mortality and limb salvage. The diagnosis is predominately clinical but may be supported by laboratory and radiological investigations. Chronic steroid use not only predisposes to the development of NF but also may mask early features delaying presentation and diagnosis. Clinicians should have a high index of suspicion especially in patients on chronic steroid therapy as this may aid in early detection and treatment. We present a case report of a successful limb salvage that exemplifies these points.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa372","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T04:53:49Z","timestamp":1597726429000},"source":"Crossref","is-referenced-by-count":3,"title":["Fulminant necrotizing fasciitis to the hand in a patient on high-dose steroids: A case report of successful limb salvage"],"prefix":"10.1093","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0488-1354","authenticated-orcid":false,"given":"Miguel","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive & Aesthetic Surgery, Queen Victoria Hospital NHS Trust, East Grinstead, UK"},{"name":"Division of Plastic Surgery, Department of Surgery, Radiology, Anaesthesia and Intensive Care, University Hospital of the West Indies, Mona Campus, Kingston, Jamaica"},{"name":"Anaesthesia and Intensive Care, University of the West Indies, Mona, Kingston, Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Berner","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive & Aesthetic Surgery, Queen Victoria Hospital NHS Trust, East Grinstead, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive & Aesthetic Surgery, Queen Victoria Hospital NHS Trust, East Grinstead, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-2327","authenticated-orcid":false,"given":"Preci","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Cornwall Regional Hospital, Montego Bay, Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pearl","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive & Aesthetic Surgery, Queen Victoria Hospital NHS Trust, East Grinstead, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"2020092306442740700_ref1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1042-3680(18)30371-1","article-title":"Medical management of cerebral metastases","volume":"7","author":"Batchelor","year":"1996","journal-title":"Neurosurg Clin N Am"},{"key":"2020092306442740700_ref2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.neuroscience.2004.05.044","article-title":"Molecular mechanisms of brain tumor edema","volume":"129","author":"Papadopoulos","year":"2004","journal-title":"Neuroscience"},{"key":"2020092306442740700_ref3","first-page":"169","article-title":"Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain 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