{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:09Z","timestamp":1753877229380,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple endocrine neoplasia type 2A (MEN2A) is a hereditary syndrome associated with tumours of the endocrine system. Principally, it is characterized by medullary thyroid carcinoma (MTC) with some individuals also developing phaeochromocytoma and hyperparathyroidism. Patients with fewer than two clinical features require either an identification of a germline rearranged in transfection mutation, or MEN2A characteristics in first-degree relatives, to establish a diagnosis of MEN2A. We present the case of a 54-year-old female with MEN2A, diagnosed by genetic screening, due to a substantial history of the disease in her ancestry. This case outlines the successful treatment of recurrent phaeochromocytoma, through the medium of radioactive iobenguane as an adjunct to surgical management. The report focuses particularly on the significance of innovative treatment strategies and forthcoming approaches to improve patient care in treating phaeochromocytoma in MEN2A.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa387","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T19:10:37Z","timestamp":1598555437000},"source":"Crossref","is-referenced-by-count":0,"title":["Phaeochromocytoma recurrence in a patient with multiple endocrine neoplasia type 2A"],"prefix":"10.1093","volume":"2020","author":[{"given":"Rishabh","family":"Gupta","sequence":"first","affiliation":[{"name":"Imperial College, School of Science, Technology and Medicine, Department of Medicine, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,17]]},"reference":[{"key":"2020101819344493600_ref1","doi-asserted-by":"crossref","first-page":"705036","DOI":"10.1155\/2012\/705036","article-title":"Genetic and clinical features of multiple endocrine neoplasia types 1 and 2","volume":"2012","author":"Romei","year":"2012","journal-title":"J Oncol"},{"key":"2020101819344493600_ref2","first-page":"5658","article-title":"CONSENSUS: Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume-title":"The Journal of Clinical Endocrinology & Metabolism","author":"Brandi","year":"2001"},{"key":"2020101819344493600_ref3","first-page":"146","article-title":"Genetic testing in multiple endocrine neoplasia and related syndromes","volume":"8","author":"Calender","year":"1998","journal-title":"Forum (Genova)"},{"key":"2020101819344493600_ref4","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors","volume":"175","author":"Fassnacht","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"2020101819344493600_ref5","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1007\/s00268-010-0494-4","article-title":"Single-access retroperitoneoscopic adrenalectomy (SARA) versus conventional retroperitoneoscopic adrenalectomy (CORA): a case-control study","volume":"34","author":"Walz","year":"2010","journal-title":"W J Surg"},{"key":"2020101819344493600_ref6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.6061\/clinics\/2012(Sup01)27","article-title":"Retroperitoneoscopic adrenalectomy in pheochromocytoma","volume":"67","author":"Hisano","year":"2012","journal-title":"Clinics"},{"author":"Corticosteroids, replacement therapy | Treatment summary | BNF content published by NICE","key":"2020101819344493600_ref7"},{"key":"2020101819344493600_ref8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s005950300078","article-title":"Functional results after endoscopic subtotal cortical-sparing Adrenalectomy","volume":"33","author":"Brauckhoff","year":"2003","journal-title":"Surg Today"},{"key":"2020101819344493600_ref9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/SLA.0b013e318237480c","article-title":"Unilateral subtotal adrenalectomy for pheochromocytoma in multiple endocrine neoplasia type 2 patients: a feasible surgical strategy","volume":"254","author":"Scholten","year":"2011","journal-title":"Ann Surg"},{"key":"2020101819344493600_ref10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00423-011-0851-2","article-title":"Minimally invasive cortical-sparing surgery for bilateral pheochromocytomas","volume":"397","author":"Alesina","year":"2012","journal-title":"Langenbecks Arch Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/10\/rjaa387\/33925792\/rjaa387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2020\/10\/rjaa387\/33925792\/rjaa387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T23:34:55Z","timestamp":1603064095000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaa387\/5928444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaa387","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,10,1]]},"article-number":"rjaa387"}}