{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:18Z","timestamp":1753877238540,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 15-year-old female with 2-year post-menarchal adolescent idiopathic scoliosis and sickle cell disease (SCD) underwent posterior scoliosis correction surgery. SCD is associated with higher rates of surgical complications, and these patients require careful management to prevent vaso-occlusive sickle cell crises (VOSCC); scoliosis correction surgery can be associated with high morbidity and mortality, including significant blood loss.<\/jats:p>\n               <jats:p>Multiple techniques were employed to successfully prevent VOSCC in this patient including a preoperative transfusion, meticulous haemostasis at osteotomy sites, not performing a costoplasty despite presence of a rib hump, maintenance of intraoperative mean arterial pressure below 70\u00a0mmHg, aggressive postoperative hydration and the use of intraoperative tranexamic acid (TXA). This is the first reported case of the use of TXA in a patient with SCD and scoliosis correction surgery.<\/jats:p>\n               <jats:p>A satisfactory correction was achieved with a longer than average inpatient stay due to non-sickle cell pain and protracted wound ooze.<\/jats:p>","DOI":"10.1093\/jscr\/rjaa559","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:19:39Z","timestamp":1609791579000},"source":"Crossref","is-referenced-by-count":0,"title":["Tranexamic acid use in a patient with sickle cell disease undergoing posterior scoliosis correction surgery: safely mitigating bleeding and vaso-occlusive crises"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-2202","authenticated-orcid":false,"given":"Millie","family":"Newall","sequence":"first","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamer A","family":"Hamdan","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisola","family":"Ajayi","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Weil","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Bishop","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren F","family":"Lui","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospital NHS Foundation Trust, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"2021052014405495000_ref1","first-page":"213","volume-title":"Tachdjian\u2019s pediatric orthopaedics","author":"Herring","year":"2002","edition":"3rd"},{"key":"2021052014405495000_ref2","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1097\/01.brs.0000236844.41595.26","article-title":"Correlates of the peak height velocity in girls with idiopathic scoliosis","volume":"31","author":"Sanders","year":"2006","journal-title":"Spine"},{"key":"2021052014405495000_ref3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2141.2005.05476.x","article-title":"Bone involvement in sickle cell disease","volume":"129","author":"Almeida","year":"2005","journal-title":"Br J Haematol"},{"key":"2021052014405495000_ref4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/BSD.0000000000000819","article-title":"Impact of sickle cell Anemia on inpatient morbidity after spinal fusion","volume":"32","author":"Lu","year":"2019","journal-title":"Clin Spine Surg"},{"key":"2021052014405495000_ref5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1055\/s-0035-1563609","article-title":"Systemic and topical use of tranexamic acid in spinal surgery: a systematic review","volume":"6","author":"Winter","year":"2016","journal-title":"Global Spine J"},{"key":"2021052014405495000_ref6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1302\/0301-620X.92B8.24237","article-title":"The biomechanics of pedicle screw-based instrumentation","volume":"92","author":"Cho","year":"2010","journal-title":"J Bone Joint Surg Br"},{"key":"2021052014405495000_ref7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s701-002-8275-z","article-title":"Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats","volume":"144","author":"Schlag","year":"2002","journal-title":"Acta Neurochir"},{"key":"2021052014405495000_ref8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/TA.0000000000002061","article-title":"Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism","volume":"86","author":"Myers","year":"2019","journal-title":"J Trauma"},{"key":"2021052014405495000_ref9","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1007\/s00586-013-2774-9","article-title":"Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials","volume":"22","author":"Li","year":"2013","journal-title":"Eur Spine J"},{"key":"2021052014405495000_ref10","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00277-010-0936-y","article-title":"Oral tranexamic acid as a novel treatment option for persistent haematuria in patients with sickle cell disease","volume":"89","author":"Davis","year":"2010","journal-title":"Ann Hematol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/1\/rjaa559\/37975766\/rjaa559.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/1\/rjaa559\/37975766\/rjaa559.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T14:42:14Z","timestamp":1621521734000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaa559\/6122813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaa559","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2021,1,1]]},"article-number":"rjaa559"}}