{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:57:07Z","timestamp":1768273027000,"version":"3.49.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present the case of a 16-year-old female with systemic lupus erythematosus who presented with shock of unclear etiology, refractory to fluid resuscitation and triple vasopressors. She suffered pulseless electrical activity and underwent cannulation onto veno-arterial extracorporeal membrane oxygenation (ECMO). After cannulation, it was discovered she had intentionally overdosed on her home medication, amlodipine, a calcium channel blocker (CCB). She was supported on ECMO, treated with IV calcium and insulin, and was able to be weaned off ECMO after 4 days. She developed oligoanuric acute kidney injury, treated with continuous renal replacement therapy followed by intermittent hemodialysis. At discharge, she was neurologically intact and did not require dialysis. Herein, we review the treatment of CCB overdose, review the literature on the use of ECMO in refractory shock due to cardiovascular medication overdose, and highlight the utility of ECMO in pediatric refractory shock and\/or cardiac arrest of unclear etiology.<\/jats:p>","DOI":"10.1093\/jscr\/rjab014","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T03:11:16Z","timestamp":1610507476000},"source":"Crossref","is-referenced-by-count":6,"title":["Extracorporeal cardiopulmonary resuscitation for the treatment of amlodipine overdose in a pediatric patient"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-1854","authenticated-orcid":false,"given":"Katherine","family":"Giuliano","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y Julia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Coletti","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Jelin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"2021030600515669400_ref1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/15563650.2019.1677022","article-title":"2018 annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 36th annual Report","volume":"57","author":"Gummin","year":"2019","journal-title":"Clin Toxicol"},{"key":"2021030600515669400_ref2","first-page":"378","article-title":"Management of Calcium Channel Blocker Toxicity in the Pediatric patient","volume":"24","author":"Bartlett","year":"2019","journal-title":"J Pediatr Pharmacol Ther JPPT"},{"key":"2021030600515669400_ref3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3109\/15563650.2014.965827","article-title":"Treatment for calcium channel blocker poisoning: a systematic review","volume":"52","author":"St-Onge","year":"2014","journal-title":"Clin Toxicol (Phila)"},{"key":"2021030600515669400_ref4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/cc4938","article-title":"Bench-to-bedside review: hyperinsulinaemia\/euglycaemia therapy in the management of overdose of calcium-channel blockers","volume":"10","author":"Lheureux","year":"2006","journal-title":"Crit Care"},{"key":"2021030600515669400_ref5","doi-asserted-by":"crossref","first-page":"R138","DOI":"10.1186\/cc8017","article-title":"Extracorporeal life support in severe drug intoxication: a retrospective cohort study of seventeen cases","volume":"13","author":"Daubin","year":"2009","journal-title":"Crit Care"},{"key":"2021030600515669400_ref6","first-page":"111","article-title":"Extracorporeal membrane oxygenation in drug overdose: a clinical case series","volume":"22","author":"Vignesh","year":"2018","journal-title":"Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med"},{"key":"2021030600515669400_ref7","volume-title":"ECMO and ECLS &gt; Registry &gt; Statistics &gt; International Summary","author":"Extracorporeal Life Support Organization"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/2\/rjab014\/36416416\/rjab014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/2\/rjab014\/36416416\/rjab014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T01:02:00Z","timestamp":1614992520000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab014\/6137287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab014","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2021,2,1]]},"article-number":"rjab014"}}