{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:03Z","timestamp":1753877223496,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute of the National Institutes of Health","award":["F30CA236031"],"award-info":[{"award-number":["F30CA236031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Primary signet ring cell carcinoma (SRCC) of the breast is extremely rare, and the associated patterns of metastatic dissemination poorly described. Here, we report the case of a 61-year-old woman presenting with acute abdominal pain. Esophagogastroduodenoscopy revealed a non-bleeding erosive gastropathy, which was biopsied and found significant for a poorly differentiated, GATA3-positive SRCC. The patient was lost to follow up until re-presenting 6\u00a0months later with a perforating duodenal ulcer and umbilical herniation. Biopsies of umbilical hernia sack contents were significant for an estrogen receptor (ER) positive SRCC, and breast examination identified a right breast mass significant for an ER positive lobular carcinoma with signet ring features, thereby affirming the diagnosis of metastatic SRCC of the breast. This case offers insight into an advanced form of a rare clinical entity, and suggests that staining for breast markers such as GATA3 should be considered for all biopsies significant for SRCC.<\/jats:p>","DOI":"10.1093\/jscr\/rjab034","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T04:13:38Z","timestamp":1611720818000},"source":"Crossref","is-referenced-by-count":2,"title":["Perforating duodenal ulcer with umbilical herniation as a metastatic complication of primary signet ring cell carcinoma of the breast"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-6597","authenticated-orcid":false,"given":"Daniel R","family":"Principe","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program, University of Illinois College of Medicine, Chicago, IL, USA"},{"name":"Department of Surgery, University of Illinois College of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Raicu","sequence":"additional","affiliation":[{"name":"University of Illinois, Metropolitan Group Hospitals General Surgery Residency, Advocate Illinois Masonic Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Cataneo","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Illinois College of Medicine, Chicago, IL, USA"},{"name":"University of Illinois, Metropolitan Group Hospitals General Surgery Residency, Advocate Illinois Masonic Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly R","family":"Beverley","sequence":"additional","affiliation":[{"name":"Library of the Health Sciences, University of Illinois College of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hyser","sequence":"additional","affiliation":[{"name":"Department of Surgery, AMITA St. Francis Hospital, Evanston, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"2021031109024714800_ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"2021031109024714800_ref2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ajcp\/73.1.31","article-title":"Signet-ring cell carcinoma of the breast: a clinicopathologic study of 24 cases","volume":"73","author":"Hull","year":"1980","journal-title":"Am J Clin 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Oncol"},{"key":"2021031109024714800_ref6","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1200\/JCO.2013.49.1159","article-title":"Metastatic lobular breast carcinoma mimicking primary signet ring adenocarcinoma in a patient with a suspected CDH1 mutation","volume":"33","author":"Mahmud","year":"2015","journal-title":"J Clin Oncol"},{"key":"2021031109024714800_ref7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/PGP.0000000000000462","article-title":"Ovarian metastases of breast cancers with signet ring cells: a report of 17 cases including 14 Krukenberg tumors","volume":"37","author":"Bennett","year":"2018","journal-title":"Int J Gynecol Pathol"},{"key":"2021031109024714800_ref8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12957-015-0538-1","article-title":"Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review","volume":"13","author":"He","year":"2015","journal-title":"World J Surg 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